Adnan Ayna
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View article: Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair
Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair Open
DNA is continuously exposed to endogenous and exogenous factors that induce oxidative modifications leading to mutations and genomic instability. Oxidative DNA damage plays a dual role, contributing to physiological signaling at low levels…
View article: Protective Effects of Chrysin Against Diclofenac‐Induced Nephrotoxicity in Rats via Attenuation of Oxidative Stress, Apoptosis and Endoplasmic Reticulum Stress
Protective Effects of Chrysin Against Diclofenac‐Induced Nephrotoxicity in Rats via Attenuation of Oxidative Stress, Apoptosis and Endoplasmic Reticulum Stress Open
Diclofenac (DCL) is a broadly prescribed non‐steroidal anti‐inflammatory drug (NSAID) for pain management and has been linked to nephrotoxicity despite its therapeutic benefits. This study provides new insights into the palliative impacts …
View article: Chrysin protects neuronal cells against carboplatin exposure-induced apoptosis and oxidative damage
Chrysin protects neuronal cells against carboplatin exposure-induced apoptosis and oxidative damage Open
Chemotherapy drugs such as carboplatin are commonly used to treat various cancers, including testicular, lung, and ovarian cancer. Although carboplatin primarily targets cancer cells, it can also damage healthy cells, including neurons, le…
View article: 18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis
18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis Open
Bisphenol A (BPA) has been commonly used in various consumer products, including water bottles, food containers, and canned food linings. However, there are concerns about its potential toxicity to human health, particularly its impact on …
View article: Evaluation of Sun Protection Factor of Northern Iraqi Propolis
Evaluation of Sun Protection Factor of Northern Iraqi Propolis Open
One of the main risk factors for skin cancer and photoaging is excessive sun exposure combined with a lack of sun protection. Incorporating natural antioxidant and anti-inflammatory agents into sunscreens and taking natural antioxidant ext…
View article: Green Synthesis of Apricot Kernel Silver Nanoparticles and Their Biological Activity
Green Synthesis of Apricot Kernel Silver Nanoparticles and Their Biological Activity Open
Silver nanoparticles (AgNPs) have been shown to have high conductivity, chemical stability, catalytic and antibacterial activities, as well as cytotoxicity on various cancer cells. Many biological resources, including plants, fungi, and ba…
View article: Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy
Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy Open
Mercuric chloride (HgCl 2 ) is extremely toxic to both humans and animals. It could be absorbed via ingestion, inhalation, and skin contact. Exposure to HgCl 2 can cause severe health effects, including damages to the gastrointestinal, res…
View article: Investigation of the Protective Effects of Chrysin Against Paclitaxel-Induced Oxidative Stress and Apoptosis in Human Neuronal SH-SY5Y Cells
Investigation of the Protective Effects of Chrysin Against Paclitaxel-Induced Oxidative Stress and Apoptosis in Human Neuronal SH-SY5Y Cells Open
In this study, the potential protective effects of chrysin, an important flavonoid, against paclitaxel-induced cell toxicity in the SH-SY5Y nerve cell line as an in vitro model, were investigated by cell viability analysis, lipid peroxidat…
View article: The effects of morin and methotrexate on pentose phosphate pathway enzymes and GR/GST/TrxR enzyme activities: An in vivo and in silico study
The effects of morin and methotrexate on pentose phosphate pathway enzymes and GR/GST/TrxR enzyme activities: An in vivo and in silico study Open
In this study, the mechanisms by which the enzymes glucose‐6‐phosphate dehydrogenase (G6PD), 6‐phosphogluconate dehydrogenase (6PGD), glutathione reductase (GR), glutathione‐S‐transferase (GST), and thioredoxin reductase (TrxR) are inhibit…
View article: Selective Antimicrobial Properties of W-Ge Nanocomposite Thin Films
Selective Antimicrobial Properties of W-Ge Nanocomposite Thin Films Open
The antimicrobial properties of W-Ge nanocomposite thin films as a function of Ge concentration were investigated within the scope of this study. The films were deposited on an AZ61Mg substrate using a magnetron sputter source with a co-de…
View article: Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells
Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells Open
Due to their high toxicity to healthy body cells, chemotherapy drugs used to treat cancer pose a serious threat to the organism. Recent studies have encouraged the utilization of bee products to prevent and treat the cancer. The specific f…
View article: Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways Open
Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side…
View article: Synthesis of a Novel Supermagnetic Fe3O4 Nanoparticles and their Congo Red Dye Removal, Cytotoxic, Antioxidant, and Antimicrobial Activities
Synthesis of a Novel Supermagnetic Fe3O4 Nanoparticles and their Congo Red Dye Removal, Cytotoxic, Antioxidant, and Antimicrobial Activities Open
Biogenic synthesis of iron nanoparticles has been reported in many studies. However, there is no such study that combines antioxidant, antimicrobial, anticancer and dye removal activities of the synthesized iron nanoparticles. The present …
View article: Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells
Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells Open
Green synthesis of silver nanoparticles (AgNPs) has been reported in several studies. However, no study focused on synthesis, characterization, and investigation of anticancer and antioxidant activities of AgNPs using Bingöl propolis. The …
View article: Anticancer, and antioxidant activities of royal jelly on HT-29 colon cancer cells and melissopalynological analysis
Anticancer, and antioxidant activities of royal jelly on HT-29 colon cancer cells and melissopalynological analysis Open
Royal jelly (RJ) is reflecting the flora around the apiaries as a result of the foraging activity of honeybees and therefore, pollen analysis could be used to verify its botanical/geographical origin. Colon cancer treatment by means of che…
View article: Antioxidant Activities of Bingöl Royal Jelly on SH-SY5Y Cells
Antioxidant Activities of Bingöl Royal Jelly on SH-SY5Y Cells Open
Royal Jelly is a bee product with high protein content is a unique nutrient for the queen honeybee. It leads to a substantial elongation of the lifetime of the queen in comparison to the worker honeybees via anti-inflammatory, anti-oxidant…
View article: Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey
Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey Open
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/me…
View article: Caffeic acid prevents hydrogen peroxide-induced oxidative damage in SH-SY5Y cell line through mitigation of oxidative stress and apoptosis
Caffeic acid prevents hydrogen peroxide-induced oxidative damage in SH-SY5Y cell line through mitigation of oxidative stress and apoptosis Open
These results reveal that CA plays a role in the protection from oxidative injury-triggered apoptosis, which makes CA a likely therapeutic compound for treatment or prevention of neurodegenerative disorders associated with oxidative injury…
View article: Content and Antimicrobial Activities of Bingol Royal Jelly
Content and Antimicrobial Activities of Bingol Royal Jelly Open
Royal jelly (RJ) is the special nutriment of the larva of queen honeybee (Apis mellifera) which is composed of several bioactive substances that include amino acids, proteins, carbohydrates, lipids, mineral salts, and vitamins. The content…
View article: APOPTOTIC EFFECTS OF BETA-CAROTENE, ALPHA-TOCOPHEROL AND ASCORBIC ACID ON PC-3 PROSTATE CANCER CELLS
APOPTOTIC EFFECTS OF BETA-CAROTENE, ALPHA-TOCOPHEROL AND ASCORBIC ACID ON PC-3 PROSTATE CANCER CELLS Open
Prostate cancer (PC) is one of the the most commonly diagnosed cancer type being the second major reason of cancer-associated death in male particularly over the age of 50. Accumulating scientific evidences suggest the role oxidative stres…
View article: Development of a Biosensor Based on Myrtle (Myrtus communis L.) Tissue Homogenate for Voltammetric Determination of Epinephrine
Development of a Biosensor Based on Myrtle (Myrtus communis L.) Tissue Homogenate for Voltammetric Determination of Epinephrine Open
Ö ZF armasotik numunelerde epinefrinin (EP) voltametrik tayini için bitki dokusuna dayalı
View article: The synthesis of new oxindoles as analogs of natural product 3,3′-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD
The synthesis of new oxindoles as analogs of natural product 3,3′-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD Open
Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In…
View article: Glyceraldehyde-3-phosphate Dehydrogenase and Fructose-1, 6-bisphosphatase of the Enteric Pathogens C. jejuni and H. pylori
Glyceraldehyde-3-phosphate Dehydrogenase and Fructose-1, 6-bisphosphatase of the Enteric Pathogens C. jejuni and H. pylori Open
Campylobacter jejuni and Helicobacter pylori are pathogens which cause gastrointestinal diseases and are therefore of significant importance. However, their metabolism and physiology is relatively poorly understood. It had been noted that …