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View article: Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast <i>Candida albicans</i>
Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast <i>Candida albicans</i> Open
Candida albicans is a commensal fungus and also the most prevalent human fungal pathogen. The ability of this opportunistic yeast to acquire and maintain homeostatic levels of manganese (Mn), particularly in the metal-limited host environm…
View article: Manganese-modulated proteome and phosphoproteome dataset in the opportunistic yeast Candida albicans
Manganese-modulated proteome and phosphoproteome dataset in the opportunistic yeast Candida albicans Open
The ability of the opportunistic yeast Candida albicans to acquire and maintain homeostatic levels of manganese (Mn), particularly in the metal-limited host environment, is an important determinant of its fitness. Although significant focu…
View article: Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen <i>Candida albicans</i>
Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen <i>Candida albicans</i> Open
Although considerable advances have been made in understanding the metabolic machinery that enables bacteria to utilize sulfur sources, many aspects of this process remain understudied in fungi. To explore the genetic circuit by which the …
View article: Whole-genome sequencing of the first <i>Candida auris</i> clinical isolate from a patient with sepsis in Palestine
Whole-genome sequencing of the first <i>Candida auris</i> clinical isolate from a patient with sepsis in Palestine Open
An isolate of the multidrug-resistant yeast Candida auris (Pal1) was identified in the urine of a patient with sepsis and sequenced using both Oxford Nanopore and Illumina sequencing technologies. Phylogenetic analysis placed C. auris Pal1…
View article: Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast <i>Candida albicans</i>
Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast <i>Candida albicans</i> Open
Candida albicans is a commensal fungus and also the most prevalent human fungal pathogen. The ability of this opportunistic yeast to acquire and maintain homeostatic levels of manganese (Mn), particularly in the metal-limited host environm…
View article: The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022
The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022 Open
Background Candida spp. are the most common cause of opportunistic fungal infections and are associated with a high mortality rate worldwide. In Palestine, the prevalence of Candida spp. infections remains elusive. Methods We performed our…
View article: FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi
FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi Open
Antimicrobial resistance (AMR) is a global threat. To optimize the use of our antifungal arsenal, we need rapid detection and monitoring tools that rely on high-quality AMR mutation data. Here, we performed a thorough manual curation of pu…
View article: Small molecule inhibitors of fungal Δ(9) fatty acid desaturase as antifungal agents against Candida auris
Small molecule inhibitors of fungal Δ(9) fatty acid desaturase as antifungal agents against Candida auris Open
Candida auris has emerged as a significant healthcare-associated pathogen due to its multidrug-resistant nature. Ongoing constraints in the discovery and provision of new antifungals create an urgent imperative to design effective remedies…
View article: In Vitro Antioxidant Properties of Lactobacillus gasseri Isolated from Fermented Milk: Isolation and Preparation of Strains and Intracellular Cell-Free Extracts, Chemical Testing (Hydrogen Peroxide, Superoxide, Hydroxyl Radical, DPPH, Ferrous Ion Chelating, and Linoleic Acid Peroxidation)
In Vitro Antioxidant Properties of Lactobacillus gasseri Isolated from Fermented Milk: Isolation and Preparation of Strains and Intracellular Cell-Free Extracts, Chemical Testing (Hydrogen Peroxide, Superoxide, Hydroxyl Radical, DPPH, Ferrous Ion Chelating, and Linoleic Acid Peroxidation) Open
Among the most accepted hypotheses that can explain the causes of aging, we found the theory of free radicals in Lactobacillus gasseri strains. We did screen the antioxidative properties of Lactobacillus gasseri strains isolated from ferme…
View article: The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022
The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022 Open
Background Candida spp. are the most common cause of opportunistic fungal infections and are associated with a high mortality rate worldwide. In Palestine, the prevalence of Candida spp. infections remains elusive. Methods We performed our…
View article: Manganese homeostasis modulates fungal virulence and stress tolerance in <i>Candida albicans</i>
Manganese homeostasis modulates fungal virulence and stress tolerance in <i>Candida albicans</i> Open
Due to the scarcity of transition metals within the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned to iron a…
View article: Regulation of copper uptake by the SWI/SNF chromatin remodeling complex in <i>Candida albicans</i> affects susceptibility to antifungal and oxidative stresses under hypoxia
Regulation of copper uptake by the SWI/SNF chromatin remodeling complex in <i>Candida albicans</i> affects susceptibility to antifungal and oxidative stresses under hypoxia Open
Candida albicans is a human colonizer and also an opportunistic yeast occupying different niches that are mostly hypoxic. While hypoxia is the prevalent condition within the host, the machinery that integrates oxygen status to tune the fit…
View article: Manganese homeostasis modulates fungal virulence and stress tolerance in<i>Candida albicans</i>
Manganese homeostasis modulates fungal virulence and stress tolerance in<i>Candida albicans</i> Open
Due to the scarcity of transition metals within the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned to iron a…
View article: The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in <i>Candida albicans</i>
The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in <i>Candida albicans</i> Open
Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans . We found that activation of the transcription factor C4_02500C_A (Adr1) conferre…
View article: The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in C.<i>albicans</i>
The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in C.<i>albicans</i> Open
Transcription factors play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans . We found that activation of the transcription factor C4_02500C_A (Adr1) conferred sign…
View article: Novel determinants of cell size homeostasis in the opportunistic yeast Candida albicans
Novel determinants of cell size homeostasis in the opportunistic yeast Candida albicans Open
The basis for commitment to cell division in late G1 phase, called Start in yeast, is a critical but still poorly understood aspect of eukaryotic cell proliferation. Most dividing cells accumulate mass and grow to a critical cell size befo…
View article: Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans
Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans Open
The ability of Candida albicans , an important human fungal pathogen, to develop filamentous forms is a crucial determinant for host invasion and virulence. While hypoxia is one of the predominant host cues that promote C. albicans filamen…
View article: Transcriptional control of hypoxic hyphal growth in the fungal pathogen <i>Candida albicans</i>
Transcriptional control of hypoxic hyphal growth in the fungal pathogen <i>Candida albicans</i> Open
Background The ability of Candida albicans , an important human fungal pathogen, to develop filamentous forms is a crucial determinant for host invasion and virulence. Filamentation is triggered by different host environmental cues. Hypoxi…
View article: High-Resolution Genome-Wide Occupancy in <i>Candida</i> spp. Using ChEC-seq
High-Resolution Genome-Wide Occupancy in <i>Candida</i> spp. Using ChEC-seq Open
Systemic fungal infections caused by Candida albicans and the “superbug” Candida auris are becoming a serious public health threat. The ability of these yeasts to cause disease is linked to their faculty to modulate the expression of genes…
View article: The Canadian Fungal Research Network: current challenges and future opportunities
The Canadian Fungal Research Network: current challenges and future opportunities Open
Fungi critically impact the health and function of global ecosystems and economies. In Canada, fungal researchers often work within silos defined by subdiscipline and institutional type, complicating the collaborations necessary to underst…
View article: High resolution genome-wide occupancy in<i>Candida spp</i>. using ChEC-seq
High resolution genome-wide occupancy in<i>Candida spp</i>. using ChEC-seq Open
To persist in their hostile and dynamic human host environments, fungal pathogens has to sense and adapt by modulating their gene expression to fulfil their cellular needs. Understanding transcriptional regulation on a global scale would u…
View article: Transcriptome Analysis Uncovers a Link Between Copper Metabolism, and Both Fungal Fitness and Antifungal Sensitivity in the Opportunistic Yeast Candida albicans
Transcriptome Analysis Uncovers a Link Between Copper Metabolism, and Both Fungal Fitness and Antifungal Sensitivity in the Opportunistic Yeast Candida albicans Open
Copper homeostasis is an important determinant for virulence of many human pathogenic fungi such as the highly prevalent yeast Candida albicans. However, beyond the copper transporter Ctr1, little is known regarding other genes and biologi…
View article: Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast <i>Candida albicans</i>
Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast <i>Candida albicans</i> Open
Copper homeostasis is an important determinant for virulence of many human pathogenic fungi such as the highly prevalent yeast Candida albicans . However, beyond the copper transporter Ctr1, little is known regarding other genes and biolog…
View article: Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia
Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia Open
A critical aspect of cell fitness is the ability to sense and adapt to variations in oxygen levels in their local environment. Candida albicans is an opportunistic yeast that is the most prevalent human fungal pathogen. While hypoxia is th…
View article: Transcriptional control of hyphal morphogenesis in<i>Candida albicans</i>
Transcriptional control of hyphal morphogenesis in<i>Candida albicans</i> Open
Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulen…
View article: Transcriptome analysis uncovers a link between copper metabolism and fungal fitness in the opportunistic yeast Candida albicans
Transcriptome analysis uncovers a link between copper metabolism and fungal fitness in the opportunistic yeast Candida albicans Open
Table S1. List of primers used in this study.Table S2. Transcripts differentially expressed in C. albicans WT (SN250) under Cu excess (+Cu) and limitation (+BCS) using a 1.5-fold change cut-off and a 5% false discovery rate.Table S3. Gene …
View article: Transcriptome analysis uncovers a link between copper metabolism and fungal fitness in the opportunistic yeast Candida albicans
Transcriptome analysis uncovers a link between copper metabolism and fungal fitness in the opportunistic yeast Candida albicans Open
Table S1. List of primers used in this study.Table S2. Transcripts differentially expressed in C. albicans WT (SN250) under Cu excess (+Cu) and limitation (+BCS) using a 1.5-fold change cut-off and a 5% false discovery rate.Table S3. Gene …
View article: A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans
A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans Open
Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. …
View article: A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen <i>Candida albicans</i>
A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen <i>Candida albicans</i> Open
Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. …
View article: The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans
The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans Open
Cell size is a complex trait that responds to developmental and environmental cues. Quantitative size analysis of mutant strain collections disrupted for protein kinases and transcriptional regulators in the pathogenic yeast Candida albica…