Adolf Koudelka
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View article: Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors
Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors Open
Cell communication systems based on polypeptide ligands use transmembrane receptors to transmit signals across the plasma membrane. In their biogenesis, receptors depend on the endoplasmic reticulum (ER)-Golgi system for folding, maturatio…
View article: FGFR2 residence in primary cilia is necessary for epithelial cell signaling
FGFR2 residence in primary cilia is necessary for epithelial cell signaling Open
Primary cilium projects from cells to provide a communication platform with neighboring cells and the surrounding environment. This is ensured by the selective entry of membrane receptors and signaling molecules, producing fine-tuned and e…
View article: Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer
Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer Open
Impaired fibroblast growth factor receptor (FGFR) signaling is associated with many human conditions, including growth disorders, degenerative diseases, and cancer. Current FGFR therapeutics are based on chemical inhibitors of FGFR tyrosin…
View article: Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy
Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy Open
Achondroplasia is the most common form of human dwarfism caused by mutations in the FGFR3 receptor tyrosine kinase. Current therapy begins at 2 years of age and improves longitudinal growth but does not address the cranial malformations in…
View article: Lipoxin A<sub>4</sub>yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling
Lipoxin A<sub>4</sub>yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling Open
The enzymatic oxidation of arachidonic acid is proposed to yield trihydroxytetraene species (termed lipoxins) that resolve inflammation via ligand activation of the formyl peptide receptor, FPR2. While cell and murine models activate signa…