Adrián I. Campos
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View article: Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium Open
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this lar…
View article: Tissue factor (F3) gene variants and thrombotic risk among middle-aged and older adults: A population-based cohort study
Tissue factor (F3) gene variants and thrombotic risk among middle-aged and older adults: A population-based cohort study Open
Background: Tissue factor (TF), encoded by the F3 gene, is the main initiator of blood coagulation. The molecular epidemiology of the F3 gene and the relation to venous thromboembolism (VTE) remains to be determined. Objectives: The aim wa…
View article: Recent Breakthroughs in Genetic and Brain Structural Correlates of Suicidal Behaviors: A Short Review
Recent Breakthroughs in Genetic and Brain Structural Correlates of Suicidal Behaviors: A Short Review Open
Suicide accounts for more than 700,000 deaths annually and is the fourth leading cause of death among individuals aged 15 to 29 years. Despite years of research to understand the etiology and pathophysiology of suicidal behavior, many ques…
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globu…
View article: Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk
Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk Open
Importance Atrial fibrillation (AF) has a substantial genetic component. The importance of polygenic risk is well established, while the contribution of rare variants to disease risk warrants characterization in large cohorts. Objective To…
View article: A deep catalogue of protein-coding variation in 983,578 individuals
A deep catalogue of protein-coding variation in 983,578 individuals Open
Rare coding variants that substantially affect function provide insights into the biology of a gene 1–3 . However, ascertaining the frequency of such variants requires large sample sizes 4–8 . Here we present a catalogue of human protein-c…
View article: Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference Open
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to …
View article: Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity Open
STUDY QUESTION Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB…
View article: Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants
Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants Open
Background Factors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the prevalence of antidepressant treatment discontinuation and identify demographic characteristics, …
View article: GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors Open
This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated wi…
View article: Regulation of Non-Canonical Proteins Encoded by Small Open Reading Frames via the Nonsense-Mediated Decay Pathway
Regulation of Non-Canonical Proteins Encoded by Small Open Reading Frames via the Nonsense-Mediated Decay Pathway Open
Immunotherapy harnesses neoantigens encoded within the human genome, but their therapeutic potential is hampered by low expression, which may be controlled by the Nonsense-Mediated Decay (NMD) pathway. This study investigates the impact of…
View article: Code and sumstats for "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores"
Code and sumstats for "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores" Open
Code and summary statistics accompanying the manuscript "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores" by Campos et al (2023)
View article: Code and sumstats for "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores"
Code and sumstats for "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores" Open
Code and summary statistics accompanying the manuscript "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores" by Campos et al (2023)
View article: Code and sumstats for "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores"
Code and sumstats for "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores" Open
Code and summary statistics accompanying the manuscript "Boosting the power of genome-wide association studies within and across ancestries using polygenic scores" by Campos et al (2023)
View article: Uncovering Novel Genetic Loci and Biological Pathways Associated with Age-Related Cataracts through GWAS Meta-Analysis
Uncovering Novel Genetic Loci and Biological Pathways Associated with Age-Related Cataracts through GWAS Meta-Analysis Open
Background Age-related cataract is a highly prevalent eye disorder that results in the clouding of the crystalline lens and is one of the leading causes of visual impairment and blindness. The disease is influenced by multiple factors incl…
View article: Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain
Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain Open
Purpose Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/s…
View article: Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.
Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts. Open
Our findings suggest that multi-item instruments provide valuable information on different aspects of suicidal thoughts or behavior but share a modest core factor with single suicidal ideation items. Retrospective, multisite collaborations…
View article: Causal associations of sleep apnea, snoring with cardiovascular diseases, and the role of body mass index: a two-sample Mendelian randomization study
Causal associations of sleep apnea, snoring with cardiovascular diseases, and the role of body mass index: a two-sample Mendelian randomization study Open
Aims Previously, observational studies have identified associations between sleep apnea (SA) and cardiovascular diseases (CVDs), whereas whether the associations are causal remain unclear. Methods and results We used the bi-directional, tw…
View article: Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring
Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring Open
Study Objectives Despite its association with severe health conditions, the etiology of sleep apnea (SA) remains understudied. This study sought to identify genetic variants robustly associated with SA risk. Methods We performed a genome-w…
View article: Plasma polyunsaturated fatty acid concentrations and sleep apnea risk: A two-sample Mendelian randomization study
Plasma polyunsaturated fatty acid concentrations and sleep apnea risk: A two-sample Mendelian randomization study Open
Background Previous observational studies have found that lower levels of circulating polyunsaturated fatty acids (PUFAs) were associated with a higher risk of sleep apnea (SA). However, the causality of the association remains unclear. Ma…
View article: Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference Open
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 studies with 88,316 MD cases and 902,757 controls to …
View article: Clinical, demographic, and genetic risk factors of treatment‐attributed suicidality in >10,000 Australian adults taking antidepressants
Clinical, demographic, and genetic risk factors of treatment‐attributed suicidality in >10,000 Australian adults taking antidepressants Open
Emergence of suicidal symptoms has been reported as a potential antidepressant adverse drug reaction. Identifying risk factors associated could increase our understanding of this phenomenon and stratify individuals at higher risk. Logistic…