Adrian D. Meehan
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View article: Altered mRNA Expression Due to Rectal Perforation in a Porcine Model – A Pilot Study
Altered mRNA Expression Due to Rectal Perforation in a Porcine Model – A Pilot Study Open
Eleven known genes were highly up-regulated after rectal perforation. These genes were mainly involved in inflammatory response, intracellular signaling and cell membrane regulation. Their corresponding proteins might potentially be clinic…
View article: Fully covered self‐expandable metal stent placed over a stapled colon anastomosis in an animal model: A pilot study of colon metabolism over the stent
Fully covered self‐expandable metal stent placed over a stapled colon anastomosis in an animal model: A pilot study of colon metabolism over the stent Open
Background and Aim Anastomotic leakage (AL) in colorectal resection and primary anastomosis is a common and feared complication. Fully covered self‐expandable metal stents (FCSEMSs) have been used for the treatment of AL. It is still unkno…
View article: Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies
Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies Open
Background Apathy is one of the most prevalent neurobehavioral manifestations in mild cognitive impairment (MCI) and is included among the behavioral and psychological symptoms of dementia (BPSD). Studies suggest that the presence of apath…
View article: Altered mRNA Expression Due to Rectum Perforation in a Porcine Model – A Pilot Study
Altered mRNA Expression Due to Rectum Perforation in a Porcine Model – A Pilot Study Open
Background Anastomotic leakage is the most serious and unwelcome complication in rectal surgery. It has a great impact on postoperative morbidity and mortality. In this pilot study changes of mRNA expression in blood were analyzed in an an…
View article: Supplementary Material for: The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis
Supplementary Material for: The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis Open
Background: Emerging evidence suggests that cognitive impairment (CI) and different etiologies of dementia, including Alzheimer’s disease (AD), are associated with vascular risk factors and atherosclerosis. In clinical practice, carotid in…
View article: Unusual case of rosacea fulminans in older man
Unusual case of rosacea fulminans in older man Open
Rosacea fulminans (RF) is characterised by the abrupt onset of discomforting and consolidating pustules and nodules, oedema, cysts and erythema. The condition is considered rare, even rarer in men. Controversy exists whether RF should be c…
View article: P688 Effect of golimumab induction therapy on histologic disease profile in patients with moderate to severe ulcerative colitis: Results from the randomised, placebo-controlled Phase 3 PURSUIT-SC trial
P688 Effect of golimumab induction therapy on histologic disease profile in patients with moderate to severe ulcerative colitis: Results from the randomised, placebo-controlled Phase 3 PURSUIT-SC trial Open
Background Histologic improvement is an emerging goal in ulcerative colitis (UC) management. We previously demonstrated in the 6-week, multicentre, randomised, placebo-controlled, double-blind Program of Ulcerative colitis Research Studies…
View article: Metabolism, infl ammation and postoperative time are the key to early diagnosis of anastomotic leak
Metabolism, infl ammation and postoperative time are the key to early diagnosis of anastomotic leak Open
Objective:The aim of the study was to fi nd laboratory samples for early diagnosis of anastomotic leak.Summary background data: Anastomotic leakage after rectal cancer surgery is a severe complication with high mortality.Outcome is highly …
View article: Characterization of Calcium Homeostasis in Lithium‐Treated Patients Reveals Both Hypercalcaemia and Hypocalcaemia
Characterization of Calcium Homeostasis in Lithium‐Treated Patients Reveals Both Hypercalcaemia and Hypocalcaemia Open
Introduction Prevalence studies demonstrate that a significant proportion of lithium‐treated patients develop hypercalcaemia (3–30%). Lithium‐associated hyperparathyroidism (LHPT) is poorly defined, and calcium homeostasis may be affected …
View article: Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial
Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial Open
In this trial of patients having coronary artery surgery, tranexamic acid did not affect death or severe disability through to 1 year after surgery. Further work should be done to explore possible beneficial effects on late cardiovascular …
View article: Movement Is the Song of the Body: Reflections on the Evolution of Rhythm and Music and Its Possible Significance for the Treatment of Parkinson’s Disease
Movement Is the Song of the Body: Reflections on the Evolution of Rhythm and Music and Its Possible Significance for the Treatment of Parkinson’s Disease Open
Schooling fish, swarms of starlings, plodding wildebeest, and musicians all display impressive synchronization. To what extent do they use acoustic cues to achieve these feats? Could the acoustic c ...
View article: Lithium‐Associated Hypercalcemia: Pathophysiology, Prevalence, Management
Lithium‐Associated Hypercalcemia: Pathophysiology, Prevalence, Management Open
Background Lithium‐associated hypercalcemia (LAH) is an ill‐defined endocrinopathy. The aim of the present study was to determine the prevalence of hypercalcemia in a cohort of bipolar patients (BP) with and without concomitant lithium tre…
View article: Movement is the Song of the Body: Reflections on the Evolution of Rhythm and Music and its Possible Significance for the Treatment of Parkinson's Disease
Movement is the Song of the Body: Reflections on the Evolution of Rhythm and Music and its Possible Significance for the Treatment of Parkinson's Disease Open
Schooling fish, swarms of starlings, plodding wildebeest, and musicians all display impressive synchronization. To what extent do they use acoustic cues to achieve these feats? Could the acoustic cues used in movement synchronization be re…
View article: A Vital Decision about Life – Doctors' and Nurses' Attitudes to Current Procedures for DNR-orders at Swedish University Hospital
A Vital Decision about Life – Doctors' and Nurses' Attitudes to Current Procedures for DNR-orders at Swedish University Hospital Open
Objective: Hospital physicians in Sweden most often decide do-not-resuscitate orders (DNR) without collaboration.Systematic pre-arrest indicators of cardiopulmonary resuscitation (CPR) do not exist.Therefore, new, and for the first time, n…