Adrian Dervan
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View article: Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing
Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing Open
Chronic wounds represent a significant clinical challenge due to persistent inflammation and impaired nerve regeneration, both of which delay healing. Conventional treatments often yield limited success and inconsistent outcomes, especiall…
View article: PolyGraph – Flexible, Biocompatible & Electrically Optimised Graphene-Polymer Composites for Next-Generation Neural Interfaces
PolyGraph – Flexible, Biocompatible & Electrically Optimised Graphene-Polymer Composites for Next-Generation Neural Interfaces Open
Neural interfacing materials must deliver exceptional electrochemical performance, while integrating safely with the central nervous system. In this study we develop PolyGraph, a flexible, conductive, and biocompatible graphene-polycaprola…
View article: 3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications
3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications Open
No effective treatments are currently available for central nervous system neurotrauma although recent advances in electrical stimulation suggest some promise in neural tissue repair. It is hypothesized that structured integration of an el…
View article: Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications
Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications Open
Spinal cord injury repair poses a significant challenge due to the hostile microenvironment of the injury site and the poor survival and function of clinically relevant transplanted cells. Here it is aimed to investigate whether tuning the…
View article: Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury
Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury Open
Spinal cord injury (SCI) results in paralysis, driven partly by widespread glutamate-induced secondary excitotoxic neuronal cell death in and around the injury site. While there is no curative treatment, the standard of care often requires…
View article: Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications
Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications Open
Schematic showing the development of the multifaceted VEGF-activated scaffolds to promote pro-regenerative environments for chronic wound applications.
View article: Are spinal cord and medulla samples from embalmed donors suitable for histological examination? A pilot study
Are spinal cord and medulla samples from embalmed donors suitable for histological examination? A pilot study Open
A general belief exists that tissue from anatomical donors, especially from the central nervous system (CNS), may not be suitable for histological investigation. This is based on the idea that fixation routinely used in embalming whilst op…
View article: Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications
Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications Open
The extracellular matrix plays a critical role in modulating cell behaviour in the developing and adult central nervous system influencing neural cell morphology, function and growth. Neurons and astrocytes, play vital roles in neural sign…
View article: The Development of Principles for Patient and Public Involvement (PPI) in Preclinical Spinal Cord Research: A Modified Delphi Study
The Development of Principles for Patient and Public Involvement (PPI) in Preclinical Spinal Cord Research: A Modified Delphi Study Open
Introduction There is currently limited guidance for researchers on Patient and Public Involvement (PPI) for preclinical spinal cord research, leading to uncertainty about design and implementation. This study aimed to develop evidence‐inf…
View article: The role of Patient and public involvement (PPI) in pre-clinical spinal cord research: An interview study
The role of Patient and public involvement (PPI) in pre-clinical spinal cord research: An interview study Open
Background Patient and public involvement in research (PPI) has many benefits including increasing relevance and impact. While using PPI in clinical research is now an established practice, the involvement of patients and the public in pre…
View article: 3D-Printing of Electroconductive MXene-based Micro-meshes in a Biomimetic Hyaluronic Acid-based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications
3D-Printing of Electroconductive MXene-based Micro-meshes in a Biomimetic Hyaluronic Acid-based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications Open
No effective treatments are currently available for central nervous system neurotrauma although recent advances in electrical stimulation suggest some promise in neural tissue repair. We hypothesized that structured integration of an elect…
View article: Perspectives of researchers and clinicians on patient and public involvement (PPI) in preclinical spinal cord research: An interview study
Perspectives of researchers and clinicians on patient and public involvement (PPI) in preclinical spinal cord research: An interview study Open
Introduction Patient and public involvement (PPI) in research is an embedded practice in clinical research, however, its role in preclinical or laboratory‐based research is less well established and presents specific challenges. This study…
View article: Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury
Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury Open
Spinal cord injury (SCI) is a devastating traumatic injury often causing permanent loss of function. The challenge of treating SCI stems from the development of a complex pathophysiology at the site of injury, involving multiple biochemica…
View article: Perspectives of Researchers and Clinicians on Patient and Public Involvement (PPI) in Preclinical Spinal Cord Research: An Interview Study
Perspectives of Researchers and Clinicians on Patient and Public Involvement (PPI) in Preclinical Spinal Cord Research: An Interview Study Open
Study Design Qualitative study Objective To explore the perspectives of preclinical spinal cord researchers and clinicians involved in the treatment of spinal cord injury on patient and public involvement (PPI) in preclinical research. Set…
View article: The role of Patient and Public Involvement (PPI) in pre-clinical spinal cord research: an interview study
The role of Patient and Public Involvement (PPI) in pre-clinical spinal cord research: an interview study Open
Background Patient and public involvement in research (PPI) has many benefits including increasing relevance and impact. While using PPI in clinical research is now an established practice, the involvement of patients and the public in pre…
View article: 3D Printing of Multifunctional Conductive Polymer Composite Hydrogels
3D Printing of Multifunctional Conductive Polymer Composite Hydrogels Open
Functional conductive hydrogels are widely used in various application scenarios, such as artificial skin, cell scaffolds, and implantable bioelectronics. However, their novel designs and technological innovations are severely hampered by …
View article: The Manufacture and Characterization of Biomimetic, Biomaterial‐Based Scaffolds for Studying Physicochemical Interactions of Neural Cells in 3D Environments
The Manufacture and Characterization of Biomimetic, Biomaterial‐Based Scaffolds for Studying Physicochemical Interactions of Neural Cells in 3D Environments Open
A particular challenge to the field of neuroscience involves translating findings from 2D in vitro systems to 3D in vivo environments. Standardized cell culture environments that adequately reflect the properties of the central nervous sys…
View article: Applying Patient and Public Involvement in preclinical research: A co‐created scoping review
Applying Patient and Public Involvement in preclinical research: A co‐created scoping review Open
Background Patient and Public Involvement (PPI) in research aims to improve the quality, relevance and appropriateness of research. PPI has an established role in clinical research where there is evidence of benefit, and where policymakers…
View article: Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair Open
Nerve guidance conduits (NGCs) are sub-optimal for long-distance injuries with inflammation and poor vascularization related to poor axonal repair. This study used a multi-factorial approach to create an optimized biomaterial NGC to addres…
View article: Biomaterial and Therapeutic Approaches for the Manipulation of Macrophage Phenotype in Peripheral and Central Nerve Repair
Biomaterial and Therapeutic Approaches for the Manipulation of Macrophage Phenotype in Peripheral and Central Nerve Repair Open
Injury to the peripheral or central nervous systems often results in extensive loss of motor and sensory function that can greatly diminish quality of life. In both cases, macrophage infiltration into the injury site plays an integral role…
View article: Patient and Public Involvement (PPI) in preclinical research: A scoping review protocol
Patient and Public Involvement (PPI) in preclinical research: A scoping review protocol Open
Introduction: Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possi…
View article: Patient and Public Involvement (PPI) in preclinical research: A scoping review protocol
Patient and Public Involvement (PPI) in preclinical research: A scoping review protocol Open
Introduction: Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possi…