Adrian Doevelaar
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View article: Prevalence of masked hypertension in attended versus unattended office blood pressure measurement
Prevalence of masked hypertension in attended versus unattended office blood pressure measurement Open
There is a controversial debate regarding whether unattended blood pressure (BP) measurement should be regarded as the new gold standard of office BP measurement. Unattended BP measurement eliminates the white‐coat effect and reduces exter…
View article: High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany
High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany Open
Background and aims Low-density lipoprotein cholesterol (LDL-C) is the main therapeutic target in the treatment of hypercholesterolemia. Small interfering RNA (siRNA) inclisiran is a new drug, which targets PCSK9 mRNA in the liver, reducin…
View article: Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019
Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019 Open
It has recently been shown that von Willebrand factor (VWF) multimers contribute to immunothrombosis in Coronavirus disease 2019 (COVID-19). Since COVID-19 is associated with an increased risk of autoreactivity, the present study investiga…
View article: Dysfunctional high-density lipoprotein in chronic inflammatory rheumatic diseases
Dysfunctional high-density lipoprotein in chronic inflammatory rheumatic diseases Open
Background: The mechanism explaining low cholesterol concentrations in chronic inflammatory rheumatic disease (CIRD) is incompletely understood. We hypothesized that chronic inflammation impairs the functionality of high-density lipoprotei…
View article: Intravenous immunoglobulins in the treatment of post‐COVID: A case–control study
Intravenous immunoglobulins in the treatment of post‐COVID: A case–control study Open
Dear Editor, The post-COVID syndrome (post-COVID) constitutes a major physical and psychological problem for many subjects after recovery from coronavirus disease 2019 (COVID-19) [1]. Symptoms include fatigue, shortness of breath, myalgia …
View article: Impact of low eGFR on the immune response against COVID-19
Impact of low eGFR on the immune response against COVID-19 Open
View article: Effect of Nephrectomy After Allograft Failure on Inflammation, Erythropoiesis, Donor-Specific Antibodies, and Outcome of Re-Transplantation
Effect of Nephrectomy After Allograft Failure on Inflammation, Erythropoiesis, Donor-Specific Antibodies, and Outcome of Re-Transplantation Open
BACKGROUND Morbidity and mortality rates are high for patients returning to dialysis after renal graft failure. Keeping failed kidney transplants in situ with concomitant minimization or withdrawal of immunosuppression is standard of care …
View article: MO149: Effect of Plasma Exchange on COVID-19 Associated Excess of Von Willebrand Factor and Inflammation in Critically Ill Patients
MO149: Effect of Plasma Exchange on COVID-19 Associated Excess of Von Willebrand Factor and Inflammation in Critically Ill Patients Open
BACKGROUND AND AIMS Ubiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Excess of von Willebrand factor (vWf) with intravascular…
View article: MO308: Urinary Biomarkers to Predict Acute Kidney Damage and Mortality In COVID-19
MO308: Urinary Biomarkers to Predict Acute Kidney Damage and Mortality In COVID-19 Open
BACKGROUND AND AIMS Acute kidney injury (AK) is a frequent condition in patients hospitalized for COVID-19. There are only few reports on the use of urinary biomarkers in COVID-19 and no data comparing the prognostic use of individual biom…
View article: Predictors of impaired SARS-CoV-2 immunity in healthcare workers after vaccination with BNT162b2
Predictors of impaired SARS-CoV-2 immunity in healthcare workers after vaccination with BNT162b2 Open
Healthcare workers are at substantially increased risk for infection with SARS-CoV-2. Successful vaccination constitutes a crucial prerequisite to protect this group during the pandemic. Since post vaccination antibody monitoring is not st…
View article: Impact of weather changes on hospital admissions for hypertension
Impact of weather changes on hospital admissions for hypertension Open
View article: Low‐density lipoprotein apheresis is associated with removal of <scp>SARS‐CoV</scp>‐2 antibodies
Low‐density lipoprotein apheresis is associated with removal of <span>SARS‐CoV</span>‐2 antibodies Open
Background Low‐density lipoprotein apheresis is not specific to lipoproteins but removes immunoglobulins as well. It remains elusive, whether protective SARS‐CoV‐2 antibodies after vaccination from COVID‐19 are eliminated as well. Methods …
View article: Effect of plasma exchange on COVID-19 associated excess of von Willebrand factor and inflammation in critically ill patients
Effect of plasma exchange on COVID-19 associated excess of von Willebrand factor and inflammation in critically ill patients Open
Ubiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Excess of Willebrand factor (vWf) with intravascular multimer formation was …
View article: Acute interstitial nephritis after vaccination with BNT162b2
Acute interstitial nephritis after vaccination with BNT162b2 Open
View article: The impact of treatment of periodic limb movements in sleep on blood pressure in patients with and without sleep apnea
The impact of treatment of periodic limb movements in sleep on blood pressure in patients with and without sleep apnea Open
View article: SARS-CoV-2–reactive cellular and humoral immunity in hemodialysis population
SARS-CoV-2–reactive cellular and humoral immunity in hemodialysis population Open
View article: Detection of SARS‐CoV‐2‐specific memory B cells to delineate long‐term COVID‐19 immunity
Detection of SARS‐CoV‐2‐specific memory B cells to delineate long‐term COVID‐19 immunity Open
The COVID-19 pandemic has led to devastating health outcomes with the death toll exceeding two million cases as of February 2021. However, there is still limited data on long-term immunity against SARS-CoV-2. Long-term immunity can be anal…
View article: Generation of Inhibitory Autoantibodies to ADAMTS13 in Coronavirus Disease 2019
Generation of Inhibitory Autoantibodies to ADAMTS13 in Coronavirus Disease 2019 Open
Objectives It has recently been shown that von Willebrand factor (vWf) multimers may be a key driver of immunothrombosis in Coronavirus disease 2019 (COVID-19). Since COVID-19 is associated with an increased risk of autoreactivity, the pre…
View article: The Magnitude and Functionality of SARS-CoV-2 Reactive Cellular and Humoral Immunity in Transplant Population Is Similar to the General Population Despite Immunosuppression
The Magnitude and Functionality of SARS-CoV-2 Reactive Cellular and Humoral Immunity in Transplant Population Is Similar to the General Population Despite Immunosuppression Open
Background. The ability of transplant (Tx) patients to generate a protective antiviral response under immunosuppression is pivotal in COVID-19 infection. However, analysis of immunity against SARS-CoV-2 is currently lacking. Methods. Here,…
View article: COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a++
COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a++ Open
View article: Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2
Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2 Open
View article: Psychological Responses to the Coronavirus Disease 2019 Pandemic in Renal Transplant Recipients
Psychological Responses to the Coronavirus Disease 2019 Pandemic in Renal Transplant Recipients Open
View article: Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients
Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients Open
View article: COVID-19 is associated with relative ADAMTS13 deficiency and VWF multimer formation resembling TTP
COVID-19 is associated with relative ADAMTS13 deficiency and VWF multimer formation resembling TTP Open
Background Thrombotic microangiopathy (TMA) has been repeatedly described in COVID-19 and may contribute to SARS-CoV-2 associated hypercoagulability. The underlying mechanisms remain elusive. We hypothesized that endothelial damage may lea…
View article: Impact of renal disease and comorbidities on mortality in hemodialysis patients with COVID-19: a multicenter experience from Germany
Impact of renal disease and comorbidities on mortality in hemodialysis patients with COVID-19: a multicenter experience from Germany Open
View article: Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient
Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient Open
View article: Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient
Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient Open
View article: The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity
The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity Open
Identification of immunogenic targets of SARS-CoV-2 is crucial for monitoring of antiviral immunity and vaccine design. Currently, mainly anti-spike (S)-protein adaptive immunity is investigated. However, also the nucleocapsid (N)- and mem…
View article: A possible role of immunopathogenesis in COVID-19 progression
A possible role of immunopathogenesis in COVID-19 progression Open
Background The efficacy of the humoral and cellular immunity determines the outcome of viral infections. An appropriate immune response mediates protection, whereas an overwhelming immune response has been associated with immune-mediated p…
View article: The SARS-COV-2 T-Cell Immunity is Directed Against the Spike, Membrane, and Nucleocapsid Protein and Associated with COVID 19 Severity
The SARS-COV-2 T-Cell Immunity is Directed Against the Spike, Membrane, and Nucleocapsid Protein and Associated with COVID 19 Severity Open