Adrián E. Granada
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View article: Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells
Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells Open
Drug tolerant persisters (DTPs) drive cancer therapy resistance by temporarily evading drug action, allowing multiple routes to eventual permanent resistance. Despite clear evidence for DTPs, the timing of their emergence, proliferative na…
View article: Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells
Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells Open
Drug tolerant persisters (DTPs) drive cancer therapy resistance by temporarily evading drug action, allowing multiple routes to eventual permanent resistance. Despite clear evidence for DTPs, the timing of their emergence, proliferative na…
View article: Multi-Drug Pharmacotyping improves Therapy Prediction in Pancreatic Cancer Organoids
Multi-Drug Pharmacotyping improves Therapy Prediction in Pancreatic Cancer Organoids Open
Patient-Derived Organoids (PDOs) represent a promising technology for therapy prediction in pancreatic cancer, with the potential of enhancing treatment outcomes and allowing more effective, personalized treatment choices. However, classif…
View article: Circadian clock features define novel breast cancer subtypes and shape drug sensitivity
Circadian clock features define novel breast cancer subtypes and shape drug sensitivity Open
The circadian clock regulates key physiological processes, including cellular responses to DNA damage. Circadian-based therapeutic strategies optimize treatment timing to enhance drug efficacy and minimize side effects, offering potential …
View article: Circadian period is compensated for repressor protein turnover rates in single cells
Circadian period is compensated for repressor protein turnover rates in single cells Open
Most mammalian cells have molecular circadian clocks that generate widespread rhythms in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known about the mechanisms …
View article: Circadian Coupling Orchestrates Cell Growth
Circadian Coupling Orchestrates Cell Growth Open
Summary Single-cell circadian oscillators exchange extracellular information to sustain coherent circadian rhythms at the tissue level. Within cells, the circadian clock and the cell cycle couple, yet the mechanisms governing this interpla…
View article: Circadian period is compensated for repressor protein turnover rates in single cells
Circadian period is compensated for repressor protein turnover rates in single cells Open
Summary Most mammalian cells possess molecular circadian clocks generating widespread rhythms, e.g. in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known about h…
View article: Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping
Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping Open
The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administra…
View article: Analysis of Complex Circadian Time Series Data Using Wavelets
Analysis of Complex Circadian Time Series Data Using Wavelets Open
Experiments that compare rhythmic properties across different genetic alterations and entrainment conditions underlie some of the most important breakthroughs in circadian biology. A robust estimation of the rhythmic properties of the circ…
View article: Analysis of complex circadian time series data using wavelets
Analysis of complex circadian time series data using wavelets Open
Experiments that compare rhythmic properties across different genetic alterations and entrainment conditions underlie some of the most important breakthroughs in circadian biology. A robust estimation of the rhythmic properties of the circ…
View article: Intercellular coupling between peripheral circadian oscillators by TGF-β signaling
Intercellular coupling between peripheral circadian oscillators by TGF-β signaling Open
Paracrine TGF-β signaling is crucial to maintain robust and coherent circadian rhythms of peripheral oscillator networks.
View article: Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells
Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells Open
The cell biology of circadian clocks is still in its infancy. Here, we describe an efficient strategy for generating knock-in reporter cell lines using CRISPR technology that is particularly useful for genes expressed transiently or at low…
View article: Optimal time frequency analysis for biological data - pyBOAT
Optimal time frequency analysis for biological data - pyBOAT Open
Methods for the quantification of rhythmic biological signals have been essential for the discovery of function and design of biological oscillators. Advances in live measurements have allowed recordings of unprecedented resolution reveali…
View article: Optimal time frequency analysis for biological data - pyBOAT
Optimal time frequency analysis for biological data - pyBOAT Open
Methods for the quantification of rhythmic biological signals have been essential for the discovery of function and design of biological oscillators. Advances in live measurements have allowed recordings of unprecedented resolution reveali…
View article: The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy
The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy Open
DNA-damaging chemotherapy often leaves residual tumor cells. Combining single-cell long-term live imaging with information theory, we found an unexpected effect: highly proliferative cells were more likely to arrest than to die, whereas mo…
View article: Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells
Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells Open
The current model of the mammalian circadian oscillator is predominantly based on data from genetics and biochemistry experiments, while the cell biology of circadian clocks is still in its infancy. Here, we describe a new strategy for the…
View article: Tuning the phase of circadian entrainment
Tuning the phase of circadian entrainment Open
The circadian clock coordinates daily physiological, metabolic and behavioural rhythms. These endogenous oscillations are synchronized with external cues (‘zeitgebers’), such as daily light and temperature cycles. When the circadian clock …