Adrian V. Fuchs
YOU?
Author Swipe
View article: Spatio-selective activation of nuclear translocation of YAP with light directs invasion of cancer cell spheroids
Spatio-selective activation of nuclear translocation of YAP with light directs invasion of cancer cell spheroids Open
View article: Effect of Chain‐End Chemistries on the Efficiency of Coupling Antibodies to Polymers Using Unnatural Amino Acids
Effect of Chain‐End Chemistries on the Efficiency of Coupling Antibodies to Polymers Using Unnatural Amino Acids Open
Novel conjugates that incorporate strategies for increasing the therapeutic payload, such as targeted polymeric delivery vehicles, have great potential in overcoming limitations of conventional antibody therapies that often exhibit immunog…
View article: Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies
Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies Open
Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of brain tumors where access to the tumor through the vasculature is restricted by the blood-brain barrier (BBB…
View article: Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery
Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery Open
There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo, as well as reducing side-effects for an increased standard o…
View article: Use of prothrombin complex concentrates in patients with decompensated liver cirrhosis is associated with thromboembolic events
Use of prothrombin complex concentrates in patients with decompensated liver cirrhosis is associated with thromboembolic events Open
View article: EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma
EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma Open
The EphA3 receptor has recently emerged as a functional tumour-specific therapeutic target in glioblastoma (GBM). EphA3 is significantly elevated in recurrent disease, is most highly expressed on glioma stem cells (GSCs), and has a functio…
View article: MBRS-09. EphA3 A NOVEL TUMOUR SPECIFIC THERAPEUTIC TARGET FOR MEDULLOBLASTOMA
MBRS-09. EphA3 A NOVEL TUMOUR SPECIFIC THERAPEUTIC TARGET FOR MEDULLOBLASTOMA Open
Targeted tumour specific therapies for children with medulloblastoma are required to improve survival and reduce the significant long-term side effects associated with current treatment protocols. Our study identifies the receptor tyrosine…
View article: PDTB-19. EphA RECEPTOR TYROSINE KINASES AS TARGETS FOR THERAPY IN PAEDIATRIC MEDULLOBLASTOMA
PDTB-19. EphA RECEPTOR TYROSINE KINASES AS TARGETS FOR THERAPY IN PAEDIATRIC MEDULLOBLASTOMA Open
Medulloblastoma is a malignant neuroepithelial tumor that arises in the cerebellum. The overall long term survival is approximately 75%, the prospects are much less optimistic for children under five where survival is less than 50%. To ach…
View article: Targeted Nanomaterials: Overcoming Instability of Antibody‐Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016)
Targeted Nanomaterials: Overcoming Instability of Antibody‐Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016) Open
Christopher B. Howard, and co-workers report the generation of targeted nanomaterials for cancer theranostics by mixing of hyperbranched polyethylene glycol polymers with bispecific antibodies (BsAbs) on page 2055. The cover represents a f…
View article: Targeted multimodal hyperbranched polymers for imaging and therapy of prostate cancer
Targeted multimodal hyperbranched polymers for imaging and therapy of prostate cancer Open
Hyperbranched polymers (HBPs) are an emerging class of promising biocompatible agents for cancer imaging and therapy. Their structure allows for conjugation with several specific functionalities. We aimed to assess imaging and therapeutic …