Adrian Hapca
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Effect of data-collection method on reporting of common mental disorder symptoms and intimate partner violence in Zimbabwe: a cluster-randomized trial Open
Background Screening for sensitive and stigmatized conditions such as mental health or experience of violence is challenging. Audio computer-assisted self-interviewing (ACASI), administered by using a tablet and headphones, may be more sen…
View article: Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial
Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial Open
Introduction Understanding genetic contributors to sarcopenia (age-related loss of muscle strength and mass) is key to finding effective therapies. Variants of the bradykinin receptor 2 (BDKRB2) have been linked to athletic and muscle perf…
View article: Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia—Analyses from the LACE randomised controlled trial
Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia—Analyses from the LACE randomised controlled trial Open
Background Ageing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass. Sarcopenia is characterised by losses in both muscle mass and strength. Body compositi…
View article: ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial
ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial Open
Background Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial wa…
View article: Development of a narrative and image-based intervention delivered by text message to support smoking cessation in pregnant women (Preprint)
Development of a narrative and image-based intervention delivered by text message to support smoking cessation in pregnant women (Preprint) Open
BACKGROUND This paper describes the development process of the ‘SKIP IT’ text messaging intervention to promote smoking cessation during pregnancy. Smoking during pregnancy is a major risk to mother and infant health. Pregnant women who s…
View article: Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia: the LACE factorial RCT
Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia: the LACE factorial RCT Open
Background Angiotensin-converting enzyme inhibitors and leucine are promising potential treatments for sarcopenia. Neither has yet been tested in adequately powered randomised trials in patients with sarcopenia. Objectives To determine the…
Randomized clinical trial: Direct‐acting antivirals as treatment for hepatitis C in people who inject drugs: Delivered in needle and syringe programs via directly observed therapy versus fortnightly collection Open
Hepatitis C virus (HCV) treatment in people who inject drugs (PWID) is delivered within settings frequented by PWID, such as needle and syringe programs (NSP). The optimal direct‐acting antiviral (DAA) dispensing regimen among NSP clients …
View article: 667 EFFECT OF LEUCINE SUPPLEMENTATION ON PHYSICAL PERFORMANCE, MUSCLE MASS AND QUALITY OF LIFE IN OLDER PEOPLE WITH SARCOPENIA
667 EFFECT OF LEUCINE SUPPLEMENTATION ON PHYSICAL PERFORMANCE, MUSCLE MASS AND QUALITY OF LIFE IN OLDER PEOPLE WITH SARCOPENIA Open
Introduction Leucine supplementation improves muscle protein synthesis in physiological studies and has been proposed as a treatment to improve muscle mass and physical performance. We tested the effects of leucine supplementation in a ran…
View article: 666 EFFECT OF PERINDOPRIL ON PHYSICAL PERFORMANCE, MUSCLE MASS AND QUALITY OF LIFE IN OLDER PEOPLE WITH SARCOPENIA: RESULTS: FROM THE
666 EFFECT OF PERINDOPRIL ON PHYSICAL PERFORMANCE, MUSCLE MASS AND QUALITY OF LIFE IN OLDER PEOPLE WITH SARCOPENIA: RESULTS: FROM THE Open
Introduction Angiotensin-converting enzyme inhibitors such as perindopril have been proposed as treatments to improve muscle mass and physical performance but have not been tested in randomised controlled trials enrolling patients with sar…
View article: Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial
Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial Open
Background This trial aimed to determine the efficacy of leucine and/or perindopril in improving physical function in older people with sarcopenia. Methods Placebo‐controlled, parallel group, double‐blind, randomized two‐by‐two factorial t…
Promoting smoking cessation during pregnancy: A feasibility and pilot trial of a digital storytelling intervention delivered via text‐messaging Open
Digital Storytelling interventions could help women quit smoking, but further research is required to identify alternative methods for studies with pregnant women who smoke.
View article: Recruitment strategies for sarcopenia trials: lessons from the LACE randomized controlled trial
Recruitment strategies for sarcopenia trials: lessons from the LACE randomized controlled trial Open
Background Sarcopenia is rarely diagnosed and is not recorded electronically in routine clinical care, posing challenges to trial recruitment. We describe the performance of four components of a strategy to efficiently recruit participants…
View article: Text messaging and financial incentives to encourage weight loss in men with obesity: the Game of Stones feasibility RCT
Text messaging and financial incentives to encourage weight loss in men with obesity: the Game of Stones feasibility RCT Open
Background In 2016, 26% of UK men were estimated to be obese. Systematic reviews suggest that few men engage in formal weight loss interventions that support weight reduction and improve health. Objective To co-produce, with patient and pu…
View article: Game of Stones: feasibility randomised controlled trial of how to engage men with obesity in text message and incentive interventions for weight loss
Game of Stones: feasibility randomised controlled trial of how to engage men with obesity in text message and incentive interventions for weight loss Open
Objectives To examine the acceptability and feasibility of narrative text messages with or without financial incentives to support weight loss for men. Design Individually randomised three-arm feasibility trial with 12 months’ follow-up. S…
The Addition of Vitamin D Supplementation to Interferon and Ribavirin in the Treatment of Hepatitis C Virus Infection: A Randomised Double-Blind Placebo-Controlled Pilot Study Open
Background: Vitamin D is known to be involved in the immune response to hepatitis C virus infection and preliminary data suggests that supplementation may improve response to treatment with interferon and ribavirin. Methods:The ViaDUCT stu…
Process evaluation of the Data-driven Quality Improvement in Primary Care (DQIP) trial: quantitative examination of variation between practices in recruitment, implementation and effectiveness Open
Objectives The cluster randomised trial of the Data-driven Quality Improvement in Primary Care (DQIP) intervention showed that education, informatics and financial incentives for general medical practices to review patients with ongoing hi…
Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD Open
Background In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear. Preclinical data suggest MBL interfere…
Symposium Mammographicum 2016 Meeting Abstracts Open
Purpose: To determine whether 3D tomosynthesis in addition to standard 2D screening mammography reduces single reader recall rate in women undergoing their first screening examination.Methods: Regional ethics committee approval was obtaine…
Safer Prescribing — A Trial of Education, Informatics, and Financial Incentives Open
A complex intervention combining professional education, informatics, and financial incentives reduced the rate of high-risk prescribing of antiplatelet medications and NSAIDs and may have improved clinical outcomes. (Funded by the Scottis…