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View article: T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanisms
T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanisms Open
γδ T cells are mediators of immunosurveillance used in the clinic. However, their status remains paradoxical. While many display overt traits of adaptive immunity, several major γδ cell subsets including those in barrier tissues make rapid…
View article: Cancer immunotherapy by γδ T cells
Cancer immunotherapy by γδ T cells Open
The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradica…
View article: Figure S7 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S7 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Impact of Btnl1 and Btnl6 expression on Vgamma7+ cells and the tumor microenvironment
View article: Table S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Table S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Clinicopathological characteristics of colon cancer patient cohorts.
View article: Figure S5 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S5 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Disruption of WNT gradient in normal intestinal villi reduces gamma delta T cells
View article: Supplementary Figure Legends from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Supplementary Figure Legends from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Supplementary Figure Legends
View article: Supplementary Figure Legends from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Supplementary Figure Legends from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Supplementary Figure Legends
View article: Figure S4 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S4 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors
View article: Figure S3 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S3 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Knockdown of Cdx1, Cdx2 and Hnf4a fails to influence organoid morphology or expression of Btnl genes
View article: Figure S3 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S3 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Knockdown of Cdx1, Cdx2 and Hnf4a fails to influence organoid morphology or expression of Btnl genes
View article: Figure S7 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S7 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Impact of Btnl1 and Btnl6 expression on Vgamma7+ cells and the tumor microenvironment
View article: Figure S4 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S4 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors
View article: Figure S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
WNT expression is independent of BTN3A1 and BTN2A1
View article: Figure S6 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S6 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.
View article: Figure S2 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S2 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Deletion of Apc in organoids increases WNT target genes
View article: Table S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Table S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Clinicopathological characteristics of colon cancer patient cohorts.
View article: Figure S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
WNT expression is independent of BTN3A1 and BTN2A1
View article: Figure S6 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S6 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.
View article: Figure S5 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S5 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Disruption of WNT gradient in normal intestinal villi reduces gamma delta T cells
View article: Figure S2 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
Figure S2 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer Open
Deletion of Apc in organoids increases WNT target genes
View article: IP10 levels refine severity prognostication in COVID-19 and implicate causes of clinical deterioration: lessons for pandemic preparedness
IP10 levels refine severity prognostication in COVID-19 and implicate causes of clinical deterioration: lessons for pandemic preparedness Open
Summary Background Emerging pandemics place immense strains on healthcare systems that may be ameliorated by rapid development of biomarkers whose measurements may predict disease severity and additionally inform about disease causation. C…
View article: Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials
Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials Open
Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex (MHC), MR1, or CD1 proteins underpin adaptive immunity. Those responses are mostly mediated by complementarity-determining region 3 motifs created by q…
View article: NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis Open
Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations ranging from benign steatosis to cirrhosis. A key event in the pathophysiology of MAFLD is the development of nonalcoholic steatohepatitis (NASH), wh…
View article: Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Open
Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in humans, we characterized the colonic γδ T cell compart…
View article: IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis
IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Open
The size and quality of the tissue-infiltrating CD8 T-cell response during ACD can be profoundly regulated by local innate-like T cells responding to IFN-γ and involving PD-L1. Thus, interindividual and tissue-specific variations in tissue…
View article: Figure S6 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer
Figure S6 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer Open
Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.
View article: Figure S1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer
Figure S1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer Open
WNT expression is independent of BTN3A1 and BTN2A1