Adrian Manea
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View article: Screening of alpha-fetoprotein, C-reactive protein and gamma-glutamyl transferase among Khat chewers
Screening of alpha-fetoprotein, C-reactive protein and gamma-glutamyl transferase among Khat chewers Open
Purpose: To evaluate the possible effects of Khat and its active ingredient, cathine, on the hepatic production of alpha-fetoprotein (AFP), C-reactive protein (CRP) and gamma-glutamyl transferase (GGT) levels among khat chewers. Methods: T…
View article: Induction of murine experimental autoimmune myocarditis – technical details, implementation and evaluation
Induction of murine experimental autoimmune myocarditis – technical details, implementation and evaluation Open
Introduction Myocarditis is a complex cardiac disorder with multifactorial etiology, characterized by myocardial inflammation, cardiomyocyte damage, and fibrosis. Left untreated, myocarditis may lead to acute and chronic heart failure and …
View article: APPLICATION OF ARTIFICIAL INTELLIGENCE IN DENTAL CARIES PREDICTION RELATED TO DIET AND ORAL HYGIENE
APPLICATION OF ARTIFICIAL INTELLIGENCE IN DENTAL CARIES PREDICTION RELATED TO DIET AND ORAL HYGIENE Open
Artificial intelligence (AI) is nowadays broadly used in dental medicine to reduce time chair, improve the quality of treatment, and perform personalized dental care. Aim of the study. The study aims to use AI to predict caries risk for ch…
View article: Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction Open
Background and Aims The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutroph…
View article: Pharmacological Inhibition of Lysine-Specific Demethylase 1A Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice by a Mechanism Involving Decreased Oxidative Stress and Inflammation; Potential Implications in Human Atherosclerosis
Pharmacological Inhibition of Lysine-Specific Demethylase 1A Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice by a Mechanism Involving Decreased Oxidative Stress and Inflammation; Potential Implications in Human Atherosclerosis Open
Dysregulated epigenetic mechanisms promote transcriptomic and phenotypic alterations in cardiovascular diseases. The role of histone methylation-related pathways in atherosclerosis is largely unknown. We hypothesize that lysine-specific de…
View article: Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney Open
Accumulating evidence implicates the histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications. Diabetic kidney disease (DKD) is a progressive chronic inflammatory microv…
View article: Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High‐Resolution Near‐Infrared Fluorescence Imaging Using VCAM‐1‐Targeted Liposomes Entrapping a Fluorogenic Redox‐Sensitive Probe
Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High‐Resolution Near‐Infrared Fluorescence Imaging Using VCAM‐1‐Targeted Liposomes Entrapping a Fluorogenic Redox‐Sensitive Probe Open
Excessive production of reactive oxygen species (ROS) and the ensuing oxidative stress are instrumental in all phases of atherosclerosis. Despite the major achievements in understanding the regulatory pathways and molecular sources of ROS …
View article: Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis Open
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations i…
View article: The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes
The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes Open
The anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of cardiotoxicity leading to the development of congestive heart failure. DOX-induced oxidative stress and changes of the phosphoproteome as well as e…
View article: Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis Open
Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of Nox5 regula…
View article: Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes
Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes Open
Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulato…