Adrian Najer
YOU?
Author Swipe
View article: Photo-PISA Driven <i>In Situ</i> Encapsulation of Nanocluster-Based Sensors within Stimuli-Responsive Polymersomes for AND Logic Gate Sensing
Photo-PISA Driven <i>In Situ</i> Encapsulation of Nanocluster-Based Sensors within Stimuli-Responsive Polymersomes for AND Logic Gate Sensing Open
Colorimetric sensing is a widely utilized analytical technique due to its simplicity, accessibility, rapid response, and broad applicability in medical diagnostics. However, improving the sensitivity and specificity of these assays remains…
View article: Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release
Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release Open
Preventing malaria parasite transmission to the mosquito vector is a key elimination challenge that could benefit from a diagnostic test that can identify transmission-competent individuals. Only sexual parasite forms, called gametocytes, …
View article: Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery
Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery Open
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. However, the pathophysiological mechanisms of CVDs are not yet fully understood, and animal models do not accurately replicate human heart function. Heart‐on‐a‐chip t…
View article: Non-invasive in vivo sensing of bacterial implant infection using catalytically-optimised gold nanocluster-loaded liposomes for urinary readout
Non-invasive in vivo sensing of bacterial implant infection using catalytically-optimised gold nanocluster-loaded liposomes for urinary readout Open
Staphylococcus aureus is a leading cause of nosocomial implant-associated infections, causing significant morbidity and mortality, underscoring the need for rapid, non-invasive, and cost-effective diagnostics. Here, we optimise the synthes…
View article: Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA
Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA Open
Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is challenging due to generally poor cell membrane permeation and endolysosomal entrapment causing degradation. Herein, these challenges are addressed…
View article: Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites
Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites Open
Global health faces an immense burden from infectious diseases caused by viruses and intracellular protozoan parasites such as the coronavirus disease (COVID‐19) and malaria, respectively. These pathogens propagate through the infection of…
View article: Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria
Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria Open
Severe malaria is a life-threatening condition that is associated with a high mortality. Severe Plasmodium falciparum infections are mediated primarily by high parasitemia and binding of infected red blood cells (iRBCs) to the blood vessel…
View article: Revealing Population Heterogeneity in Vesicle-Based Nanomedicines Using Automated, Single Particle Raman Analysis
Revealing Population Heterogeneity in Vesicle-Based Nanomedicines Using Automated, Single Particle Raman Analysis Open
The intrinsic heterogeneity of many nanoformulations is currently challenging to characterize on both the single particle and population level. Therefore, there is great opportunity to develop advanced techniques to describe and understand…
View article: Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting
Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting Open
Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer theranostics because of their high absorption coefficients, photostability, and biocompatibility. However, SPNs are susceptible to aggregation and protein …
View article: Differences in Human Plasma Protein Interactions between Various Polymersomes and Stealth Liposomes as Observed by Fluorescence Correlation Spectroscopy
Differences in Human Plasma Protein Interactions between Various Polymersomes and Stealth Liposomes as Observed by Fluorescence Correlation Spectroscopy Open
A significant factor hindering the clinical translation of polymersomes as vesicular nanocarriers is the limited availability of comparative studies detailing their interaction with blood plasma proteins compared to liposomes. Here, polyme…
View article: Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors Open
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing poly…
View article: Raw research data supporting "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors "
Raw research data supporting "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors " Open
Research data supporting Rifaie-Graham et al. "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors."Nature Chemistry. 2022. DOI:10.1038/s41557-022-01062-4.
View article: Raw research data supporting "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors "
Raw research data supporting "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors " Open
Research data supporting Rifaie-Graham et al. "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors."Nature Chemistry. 2022. DOI:10.1038/s41557-022-01062-4.
View article: Microliter Scale Synthesis of Luciferase‐Encapsulated Polymersomes as Artificial Organelles for Optogenetic Modulation of Cardiomyocyte Beating
Microliter Scale Synthesis of Luciferase‐Encapsulated Polymersomes as Artificial Organelles for Optogenetic Modulation of Cardiomyocyte Beating Open
Constructing artificial systems that effectively replace or supplement natural biological machinery within cells is one of the fundamental challenges underpinning bioengineering. At the sub‐cellular scale, artificial organelles (AOs) have …
View article: Block Length‐Dependent Protein Fouling on Poly(2‐oxazoline)‐Based Polymersomes: Influence on Macrophage Association and Circulation Behavior
Block Length‐Dependent Protein Fouling on Poly(2‐oxazoline)‐Based Polymersomes: Influence on Macrophage Association and Circulation Behavior Open
Polymersomes are vesicular structures self‐assembled from amphiphilic block copolymers and are considered an alternative to liposomes for applications in drug delivery, immunotherapy, biosensing, and as nanoreactors and artificial organell…
View article: Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo
Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo Open
Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functio…
View article: Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant <i>Staphylococcus aureus</i> (MRSA) Infection
Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant <i>Staphylococcus aureus</i> (MRSA) Infection Open
Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria‐acti…
View article: Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity
Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity Open
A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immun…
View article: Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors Open
The circadian rhythm generates out-of-equilibrium metabolite oscillations controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing polymersomes …
View article: Research data supporting "Tumor-targeting cholesterol decorated DNA nanoflowers for intracellular ratiometric aptasensing"
Research data supporting "Tumor-targeting cholesterol decorated DNA nanoflowers for intracellular ratiometric aptasensing" Open
Raw data supporting Kim N. et al., "Tumor-targeting cholestero-decorated DNA nanoflowers for intracellular ratiometric aptasensin" (2021). DOI: 10.1002/adma.202007738.
View article: Research data supporting "Tumor-targeting cholesterol decorated DNA nanoflowers for intracellular ratiometric aptasensing"
Research data supporting "Tumor-targeting cholesterol decorated DNA nanoflowers for intracellular ratiometric aptasensing" Open
Raw data supporting Kim N. et al., "Tumor-targeting cholestero-decorated DNA nanoflowers for intracellular ratiometric aptasensin" (2021). DOI: 10.1002/adma.202007738.
View article: Tumor‐Targeting Cholesterol‐Decorated DNA Nanoflowers for Intracellular Ratiometric Aptasensing
Tumor‐Targeting Cholesterol‐Decorated DNA Nanoflowers for Intracellular Ratiometric Aptasensing Open
Probing endogenous molecular profiles is of fundamental importance to understand cellular function and processes. Despite the promise of programmable nucleic‐acid‐based aptasensors across the breadth of biomolecular detection, target‐respo…
View article: Research data supporting "A Controlled Dendrimersome Nanoreactor System for Localised Hypochlorite-Induced Killing of Bacteria"
Research data supporting "A Controlled Dendrimersome Nanoreactor System for Localised Hypochlorite-Induced Killing of Bacteria" Open
Raw research data supporting: Potter M. et al., ACS Nano (2020), DOI: 10.1021/acsnano.0c07459.
View article: Controlled Dendrimersome Nanoreactor System for Localized Hypochlorite-Induced Killing of Bacteria
Controlled Dendrimersome Nanoreactor System for Localized Hypochlorite-Induced Killing of Bacteria Open
Antibiotic resistance is a serious global health problem necessitating new bactericidal approaches such as nanomedicines. Dendrimersomes (DSs) have recently become a valuable alternative nanocarrier to polymersomes and liposomes due to the…
View article: Research data supporting "A Controlled Dendrimersome Nanoreactor System for Localised Hypochlorite-Induced Killing of Bacteria"
Research data supporting "A Controlled Dendrimersome Nanoreactor System for Localised Hypochlorite-Induced Killing of Bacteria" Open
Raw research data supporting: Potter M. et al., ACS Nano (2020), DOI: 10.1021/acsnano.0c07459.
View article: Neutrophils Enable Local and Non‐Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart
Neutrophils Enable Local and Non‐Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart Open
Uncontrolled inflammation is a major pathological factor underlying a range of diseases including autoimmune conditions, cardiovascular disease, and cancer. Improving localized delivery of immunosuppressive drugs to inflamed tissue in a no…
View article: Multicompartment Polymer Vesicles with Artificial Organelles for Signal‐Triggered Cascade Reactions Including Cytoskeleton Formation
Multicompartment Polymer Vesicles with Artificial Organelles for Signal‐Triggered Cascade Reactions Including Cytoskeleton Formation Open
Organelles, i.e., internal subcompartments of cells, are fundamental to spatially separate cellular processes, while controlled intercompartment communication is essential for signal transduction. Furthermore, dynamic remodeling of the cyt…
View article: Tuneable Peptide Cross-Linked Nanogels for Enzyme Triggered Protein Delivery
Tuneable Peptide Cross-Linked Nanogels for Enzyme Triggered Protein Delivery Open
Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug delivery to achieve disease- or site-specific cargo release. Self-assembled polym…
View article: Tuneable Peptide Cross-Linked Nanogels for Enzyme Triggered Protein Delivery
Tuneable Peptide Cross-Linked Nanogels for Enzyme Triggered Protein Delivery Open
Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug delivery to achieve disease- or site-specific cargo release. Self-assembled polym…