Adrian Paez
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View article: Imaging the distribution and drainage of fluid in the human olfactory regions using intravenous Gadolinium-based contrast agents (GBCA) enhanced MRI
Imaging the distribution and drainage of fluid in the human olfactory regions using intravenous Gadolinium-based contrast agents (GBCA) enhanced MRI Open
Intravenous-GBCA-enhanced-MRI can detect GBCA distribution in the CSF space of olfactory regions in healthy subjects. The GBCA-induced CSF signal changes in intracranial olfactory regions were substantially smaller compared to extracranial…
Technical considerations for using intravenous gadolinium-based-contrast-agent (GBCA) based MRI approaches to study cerebrospinal fluid (CSF) circulation and clearance Open
Intravenously (IV) administered Gadolinium-based-contrast-agents (GBCAs) can enter the intracranial cerebrospinal-fluid (CSF) space via weak barriers between blood and CSF at multiple locations in the brain. This enables IV-GBCAs to be use…
High‐resolution 7‐Tesla magnetic resonance imaging and post‐processing for 3‐dimensional reconstruction of the membranous labyrinth in healthy adults Open
The membranous labyrinth of the inner ear is a complex network of endolymph‐filled structures critical for auditory and vestibular function. Pathological distension of these spaces, termed endolymphatic hydrops (EH), is associated with dis…
Abnormal arteriolar blood volume measured by 3D inflow-based vascular-space-occupancy (iVASO) MRI and resting-state BOLD fluctuations at 7 T in individuals with recent-onset schizophrenia Open
Background We previously reported lower baseline arteriolar cerebral blood volumes (CBVa) in almost all gray matter regions in a cohort of individuals with schizophrenia of varying ages and disease duration. The extent to which decreased C…
Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects Open
Background Pathways for intravenously administered gadolinium-based-contrast-agents (GBCAs) entering cerebrospinal-fluid (CSF) circulation in the human brain are not well-understood. The blood-CSF-barrier (BCSFB) in choroid-plexus (CP) has…
View article: Imaging arterial and venous vessels using Iron Dextran enhanced multi‐echo 3D gradient echo MRI at 7T
Imaging arterial and venous vessels using Iron Dextran enhanced multi‐echo 3D gradient echo MRI at 7T Open
Iron Dextran is a widely used iron oxide compound to treat iron‐deficiency anemia patients in the clinic. Similar to other iron oxide compounds such as Ferumoxytol, it can also be used off‐label as an intravascular magnetic resonance imagi…
Differential functional change in olfactory bulb and olfactory eloquent areas in Parkinson’s disease Open
Olfactory dysfunction, or hyposmia, frequently occurs as a prodromal symptom and ongoing sign of Parkinson’s disease. Functional MRI is a powerful tool for studying functional changes in the olfactory brain regions in patients with Parkins…
View article: On the optimization of <scp>3D</scp> inflow‐based vascular‐space‐occupancy (<scp>iVASO</scp>) <scp>MRI</scp> for the quantification of arterial cerebral blood volume (<scp>CBVa</scp>)
On the optimization of <span>3D</span> inflow‐based vascular‐space‐occupancy (<span>iVASO</span>) <span>MRI</span> for the quantification of arterial cerebral blood volume (<span>CBVa</span>) Open
Purpose The inflow‐based vascular‐space‐occupancy (iVASO) MRI was originally developed in a single‐slice mode to measure arterial cerebral blood volume (CBVa). When vascular crushers are applied in iVASO, the signals can be sensitized pred…
Acoustic Noise Levels in High‐field Magnetic Resonance Imaging Scanners Open
7‐Tesla (T) magnetic resonance imaging may allow for higher resolution images but may produce greater acoustic noise than 1.5‐ and 3‐T scanners. We sought to characterize the intensity of acoustic noise from 7‐ versus 3‐T scanners. A‐weigh…
Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex Open
The hierarchically organized structures of the medial temporal lobe are critically important for episodic memory function. Accumulating evidence suggests dissociable information processing pathways are maintained throughout these structure…
Evaluation of T2-prepared blood oxygenation level dependent functional magnetic resonance imaging with an event-related task: Hemodynamic response function and reproducibility Open
T2-prepared (T2prep) blood oxygenation level dependent (BOLD) functional MRI (fMRI) is an alternative fMRI approach developed to mitigate the susceptibility artifacts that are typically observed in brain regions near air-filled cavities, b…
View article: Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders
Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders Open
Smell deficits and neurobiological changes in the olfactory bulb (OB) and olfactory epithelium (OE) have been observed in schizophrenia and related disorders. The OE is the most peripheral olfactory system located outside the cranium, and …
Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T Open
Olfaction is a fundamental sense that plays a vital role in daily life in humans, and can be altered in neuropsychiatric and neurodegenerative diseases. Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) …
Volumetric alteration of olfactory bulb and immune-related molecular changes in olfactory epithelium in first episode psychosis patients Open
Background Olfactory dysfunction has been reproducibly reported in patients with psychosis, including first episode psychosis (FEP) patients. Consistently, structural abnormalities in the olfactory bulb (OB), a key region of the peripheral…
View article: Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study
Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study Open
Cognitive impairment amongst Parkinson’s disease (PD) patients is highly prevalent and associated with an increased risk of dementia. There is growing evidence that altered cerebrovascular functions contribute to cognitive impairment. Few …
Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington’s disease Open
Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG triplet repeat expansion in the Huntingtin gene. Metabolic and microvascular abnormalities in the brain may contribute to early physiological changes that subserve th…
Fast whole brain MR imaging of dynamic susceptibility contrast changes in the cerebrospinal fluid (cDSC MRI) Open
Purpose The circulation of cerebrospinal fluid (CSF) is closely associated with many aspects of brain physiology. When gadolinium(Gd)‐based contrast is administered intravenously, pre‐ and post‐contrast MR signal changes can often be obser…
Suture-Button Device Stabilization Following Ring Finger Ray Amputation: A Comparative Cadaver Study Open
Background: The purpose of this study was to determine whether placing the suture-button device between the long and small finger metacarpals following ring finger ray amputation may better close the intermetacarpal gap and allow early ran…
Is Dual Semitendinosus Allograft Stronger Than Turndown for Achilles Tendon Reconstruction? An In Vitro Analysis Open
Further study of dual semitendinosus allograft for treatment of severe Achilles tendon defects with cyclic loading and investigation of clinical results will better elucidate the clinical utility and indications for this technique.