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View article: Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression
Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression Open
Background Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as breakthrough weight loss agents. However, discontinuation is common, and clinical trials have demonstrated significant weight regain following cessation. In th…
View article: Educational and Practice Needs of Laboratory Profession - Findings From an IFCC Survey.
Educational and Practice Needs of Laboratory Profession - Findings From an IFCC Survey. Open
Many of the topics highlighted by the laboratory practitioners have matching IFCC functional units. They can be engaged to developed freely accessible educational and practice guidelines resources to maintain the standards of profession of…
View article: Metachronous Gastrointestinal Stromal Tumors of Different Histologies: An Unusual Case
Metachronous Gastrointestinal Stromal Tumors of Different Histologies: An Unusual Case Open
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors accounting for only a small fraction of all primary malignant tumors of the gastrointestinal tract. Histologically, GISTs are classified as epithelioid, spindle type, or mixed.…
View article: Dual <scp>glucagon‐like peptide</scp> ‐1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesity
Dual <span>glucagon‐like peptide</span> ‐1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesity Open
Aims To establish which components of energy balance mediate the clinically significant weight loss demonstrated with use of cotadutide, a glucagon‐like peptide‐1 (GLP‐1)/glucagon receptor dual agonist, in early‐phase studies. Materials an…
View article: The Advances in Computer Vision That Are Enabling More Autonomous Actions in Surgery: A Systematic Review of the Literature
The Advances in Computer Vision That Are Enabling More Autonomous Actions in Surgery: A Systematic Review of the Literature Open
This is a review focused on advances and current limitations of computer vision (CV) and how CV can help us obtain to more autonomous actions in surgery. It is a follow-up article to one that we previously published in Sensors entitled, “A…
View article: Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes Open
Background This work is aimed at improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis by generating a multi-omic disease signature. Methods/results We combined classic plasma biochemi…
View article: Surgical data science – from concepts toward clinical translation
Surgical data science – from concepts toward clinical translation Open
Recent developments in data science in general and machine learning in particular have transformed the way experts envision the future of surgery. Surgical Data Science (SDS) is a new research field that aims to improve the quality of inte…
View article: A comparative study of community and militancy in two coalmining settlements in Britain
A comparative study of community and militancy in two coalmining settlements in Britain Open
Miners' militancy and close-knit community have become synonymous terms in many people's minds. Miners displayed solidaristic tendencies above ground in their union activities as a mirror image of their relationships below ground. The toug…
View article: Quality of and Attention to Instructions in Telementoring
Quality of and Attention to Instructions in Telementoring Open
There is a long-standing interest in CSCW on distributed instruction - both in how it differs from collocated instruction as well as the design of tools to reduce any deficiencies. In this study, we leveraged the unique environment of lapa…
View article: Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes Open
Improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis are ongoing healthcare challenges. Using plasma biomarkers analysis coupled with the transcriptional and epigenetic characterisati…
View article: How Trainees Use the Information from Telepointers in Remote Instruction
How Trainees Use the Information from Telepointers in Remote Instruction Open
Researchers have shown both performance drawbacks and benefits of using telepointers or similar display overlay-technologies in remote instruction; however, there is not a clear understanding of why there are these performance effects. Thi…
View article: Magnetic Sphincter Augmentation Superior to Proton Pump Inhibitors for Regurgitation in a 1-Year Randomized Trial
Magnetic Sphincter Augmentation Superior to Proton Pump Inhibitors for Regurgitation in a 1-Year Randomized Trial Open
In a prospective study, we found MSA to reduce regurgitation in 95% of patients with moderate to severe regurgitation despite once-daily PPI therapy. MSA is superior to twice-daily PPIs therapy in reducing regurgitation. Relief of regurgit…
View article: Effects of a Virtual Pointer on Trainees’ Cognitive Load and Communication Efficiency in Surgical Training
Effects of a Virtual Pointer on Trainees’ Cognitive Load and Communication Efficiency in Surgical Training Open
We investigated the cognitive load effect of a trainer providing surgical instruction by pointing/drawing over laparoscopic video to a trainee. Results showed that while cognitive load is higher overall with the use of the instructional sy…
View article: Communication Cost of Single-user Gesturing Tool in Laparoscopic Surgical Training
Communication Cost of Single-user Gesturing Tool in Laparoscopic Surgical Training Open
Multi-user input over a shared display has been shown to support group process and improve performance. However, current gesturing systems for instructional collaborative tasks limit the input to experts and overlook the needs of novices i…
View article: The Cambridge Intensive Weight Management Programme Appears to Promote Weight Loss and Reduce the Need for Bariatric Surgery in Obese Adults
The Cambridge Intensive Weight Management Programme Appears to Promote Weight Loss and Reduce the Need for Bariatric Surgery in Obese Adults Open
Objectives: To investigate the impact of the Cambridge Intensive Weight Management Programme (IWMP) on weight change, eligibility for bariatric surgery, HbA1c, and blood pressure. Design: Prospective non-randomized intervention. Setting: T…
View article: Surgical Data Science: A Consensus Perspective
Surgical Data Science: A Consensus Perspective Open
Surgical data science is a scientific discipline with the objective of improving the quality of interventional healthcare and its value through capturing, organization, analysis, and modeling of data. The goal of the 1st workshop on Surgic…
View article: Surgery 4.0: the natural culmination of the industrial revolution?
Surgery 4.0: the natural culmination of the industrial revolution? Open
The topic of this issue of Innovative Surgical Sciences (ISS) is “Surgery 4.0”. The term and its meaning are as yet unfamiliar to most surgeons. It was, to our knowledge, coined in 2016 [1] and was used to describe a vital development in s…
View article: Surgical Training in Low-Resource Settings
Surgical Training in Low-Resource Settings Open
Building on the historical resolve of the World Health Organization (WHO) and World Health Association (WHA) mandates, this chapter offers perspective on delivery, in its many varieties, of surgical education within low- and middle-income …
View article: Biochemical consequences of bariatric surgery for extreme clinical obesity
Biochemical consequences of bariatric surgery for extreme clinical obesity Open
Obesity, defined as a body mass index over 30 kg/m 2 for adults, poses a major healthcare challenge with important economic, personal and social consequences. Although public health measures, lifestyle change and pharmacological therapies …