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View article: Targeting Overtreatment of Asymptomatic Bacteriuria in the Emergency Department: Results from a Quasi-Experimental Clinical Pharmacist-Led Program Based on Education and Audit
Targeting Overtreatment of Asymptomatic Bacteriuria in the Emergency Department: Results from a Quasi-Experimental Clinical Pharmacist-Led Program Based on Education and Audit Open
Background: Asymptomatic bacteriuria (ASB) is frequently overtreated in emergency departments (EDs), contributing to antimicrobial resistance without improving clinical outcomes. The rapid pace of clinical decision-making and high patient …
View article: Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy
Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy Open
Finerenone (FIN), a non-steroidal mineralocorticoid receptor antagonist, improves kidney and cardiovascular damage in type 1 diabetic (T1DM) Munich Wistar Frömter (MWF) rats with established chronic kidney disease (CKD). We tested whether …
View article: Short-term exposure to lauric acid promotes adipose tissue lipolysis and reduces leptin expression via a PPARγ-dependent mechanism
Short-term exposure to lauric acid promotes adipose tissue lipolysis and reduces leptin expression via a PPARγ-dependent mechanism Open
Coconut oil has gained popularity for its potential health benefits, particularly regarding energy metabolism. One of its key components, lauric acid (LA), has been reported to reduce body fat and improve insulin sensitivity, making it ben…
View article: Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner
Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner Open
Consumption of saturated fat-enriched diets during adolescence has been closely associated with the reduction of hippocampal synaptic plasticity and the impairment of cognitive function. Nevertheless, the effect of long-term intake of thes…
View article: Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy Open
Andrés Pastor Fernández was a recipient of a predoctoral fellowship from the Spanish Association Against Cancer – AECC (PRDMA18011PAST). Cristina Pantoja and Marta Barradas were funded by the Madrid Institute for Advanced Studies (IMDEA) F…
View article: Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models Open
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of …
View article: Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity Open
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and …
View article: Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity Open
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and …
View article: Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity Open
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and …
View article: Effect of Lauric vs. Oleic Acid-Enriched Diets on Leptin Autoparacrine Signalling in Male Mice
Effect of Lauric vs. Oleic Acid-Enriched Diets on Leptin Autoparacrine Signalling in Male Mice Open
High-fat diets enriched with lauric acid (SOLF) do not enhance leptin production despite expanding white adipose tissue (WAT). Our study aimed at identifying the influence of SOLF vs. oleic acid-enriched diets (UOLF) on the autoparacrine e…
View article: Cholecystokinin promotes functional expression of the aquaglycerol channel aquaporin 7 in adipocytes
Cholecystokinin promotes functional expression of the aquaglycerol channel aquaporin 7 in adipocytes Open
Background and Purpose Cholecystokinin (CCK) promotes triglyceride storage and adiponectin production in white adipose tissue (WAT), suggesting that CCK modulates WAT homeostasis. Our goal was to investigate the role of CCK in regulating t…
View article: Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice
Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice Open
Consumption of high-fat diets (HFD) has been associated with neuronal plasticity deficits and cognitive disorders linked to the alteration of glutamatergic disorders in the hippocampus. As young individuals are especially vulnerable to the…
View article: Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin
Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin Open
Senescent cells accumulate with obesity in the white adipose tissue of mice and humans. These senescent cells enhance the pro-inflammatory environment that, with time, contributes to the onset of glucose intolerance and type 2 diabetes. Gl…
View article: Energy Restriction and Colorectal Cancer: A Call for Additional Research
Energy Restriction and Colorectal Cancer: A Call for Additional Research Open
Colorectal cancer has the second highest cancer-related mortality rate, with an estimated 881,000 deaths worldwide in 2018. The urgent need to reduce the incidence and mortality rate requires innovative strategies to improve prevention, ea…
View article: Caloric restriction induces H2O2 formation as a trigger of AMPK-eNOS-NO pathway in obese rats: Role for CAMKII
Caloric restriction induces H2O2 formation as a trigger of AMPK-eNOS-NO pathway in obese rats: Role for CAMKII Open
Caloric restriction (CR) improves endothelial function through the upregulation of adenosine monophosphate-activated protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS). Moreover, hydrogen peroxide (H2O2) is upregulated in y…
View article: The cholecystokinin receptor agonist, CCK‐8, induces adiponectin production in rat white adipose tissue
The cholecystokinin receptor agonist, CCK‐8, induces adiponectin production in rat white adipose tissue Open
Background and Purpose A cholecystokinin (CCK) system has been identified in white adipose tissue (WAT). Nevertheless, the endocrine actions of CCK on WAT remain unknown. Our goal was to investigate the role of CCK in regulating the produc…