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View article: Lower Thyroid Function and Higher Plasma Choline: Effect Modification by Metabolic Dysfunction-Associated Steatotic Liver Disease
Lower Thyroid Function and Higher Plasma Choline: Effect Modification by Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Evidence is accumulating that there is a bidirectional relationship between thyroid function and the gut microbiome. We assessed associations of gut microbiome-derived circulating metabolites, choline, trimethylamine N-oxide (TMAO), and be…
View article: Plasma creatine, estimated intramuscular creatine, transcellular gradient and the risk of mortality: Results from the PREVEND study
Plasma creatine, estimated intramuscular creatine, transcellular gradient and the risk of mortality: Results from the PREVEND study Open
Background Creatine, an endogenous compound essential for energy metabolism and cellular function, has been associated with numerous beneficial effects in sports and overall health. Here, we investigated relationships between plasma creati…
View article: Potential Health Benefits of Dietary Tree Nut and Peanut Enrichment in Kidney Transplant Recipients—An In-Depth Narrative Review and Considerations for Future Research
Potential Health Benefits of Dietary Tree Nut and Peanut Enrichment in Kidney Transplant Recipients—An In-Depth Narrative Review and Considerations for Future Research Open
Kidney transplant recipients face a substantial burden of premature mortality and morbidity, primarily due to persistent inflammation, cardiovascular risk, and nutritional deficiencies. Traditional nutritional interventions in this populat…
View article: Plasma creatine, estimated intramuscular creatine and risk of mortality in stable kidney transplant recipients: Results from the TransplantLines biobank and cohort study
Plasma creatine, estimated intramuscular creatine and risk of mortality in stable kidney transplant recipients: Results from the TransplantLines biobank and cohort study Open
Creatine homeostasis markers are associated with mortality in a sex-specific manner in KTR, suggesting a potential role for creatine metabolism in patient prognosis. Future studies should explore underlying mechanisms and the potential of …
View article: Circulating FGF21 and Ketone Bodies Modify the Risk of MASLD and Mortality: Insights from the PREVEND Cohort Study
Circulating FGF21 and Ketone Bodies Modify the Risk of MASLD and Mortality: Insights from the PREVEND Cohort Study Open
Fibroblast growth factor 21 (FGF21) and ketone bodies are markers of metabolic dysregulation, independently associated with metabolic-dysfunction-associated steatotic liver disease (MASLD) and mortality. We studied their interaction with M…
View article: Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality
Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality Open
Background and Objectives This population‐based study explores associations of fibroblast growth factor 21 (FGF21), a key modulator of processes linked to protein metabolism, with protein intake and muscle mass, and their relationships wit…
View article: Plasma Beta-Hydroxybutyrate and All-Cause Mortality in Patients with Liver Cirrhosis
Plasma Beta-Hydroxybutyrate and All-Cause Mortality in Patients with Liver Cirrhosis Open
Background: Liver cirrhosis is often accompanied by metabolic dysfunction. Circulating β-hydroxybutyrate (BHB), the most abundant ketone body, is an emerging metabolic biomarker of mitochondrial dysfunction. Methods: In this prospective ob…
View article: Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study
Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study Open
View article: Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients
Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients Open
View article: Adapting Clinical and Research Practice to Global Warming
Adapting Clinical and Research Practice to Global Warming Open
View article: Creatinine clearance/eGFR ratio: a simple index for muscle mass related to mortality in ICU patients
Creatinine clearance/eGFR ratio: a simple index for muscle mass related to mortality in ICU patients Open
View article: Association between objectively measured protein intake and muscle status, health-related quality of life, and mortality in hemodialysis patients
Association between objectively measured protein intake and muscle status, health-related quality of life, and mortality in hemodialysis patients Open
View article: Diet, muscle status and creatine homeostasis
Diet, muscle status and creatine homeostasis Open
Our studies focused on hemodialysis patients and kidney transplant recipients. In hemodialysis patients, using a combined collection of urine and dialysate, we provided an unbiased assessment of their intake of protein, sodium, potassium, …
View article: Further improvement of circuit survival in citrate based continuous renal replacement therapy
Further improvement of circuit survival in citrate based continuous renal replacement therapy Open
Background Continuous renal replacement therapy (CRRT) is the most frequently used modality of renal replacement therapy (RRT) in critical care patients with acute kidney injury (AKI). Adequate CRRT delivery can be challenging, due to prob…
View article: Creatinine, cystatin C, muscle mass, and mortality: Findings from a primary and replication population‐based cohort
Creatinine, cystatin C, muscle mass, and mortality: Findings from a primary and replication population‐based cohort Open
Background Serum creatinine is used as initial test to derive eGFR and confirmatory testing with serum cystatin C is recommended when creatinine‐based eGFR is considered less accurate due to deviant muscle mass. Low muscle mass is associat…
View article: Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls
Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls Open
View article: Plasma symmetric dimethylarginine and kidney graft function in kidney transplant recipients
Plasma symmetric dimethylarginine and kidney graft function in kidney transplant recipients Open
Journal Article Accepted manuscript Plasma Symmetric Dimethylarginine and Kidney Graft Function in Kidney Transplant Recipients Get access Daan Kremer, Daan Kremer University of Groningen, University Medical Center Groningen, Department of…
View article: #2370 Creatinine, cystatin C, muscle mass, and mortality: findings from a primary and replication population-based cohort
#2370 Creatinine, cystatin C, muscle mass, and mortality: findings from a primary and replication population-based cohort Open
Background and Aims Creatinine measures are used as initial test to derive eGFR and confirmatory testing with circulating cystatin C is recommended when creatinine-based eGFR is considered less accurate due to deviant muscle mass. Low musc…
View article: #1462 Muscle mass, muscle strength, and health-related quality of life in kidney transplant recipients results of the TransplantLines Biobank & cohort study
#1462 Muscle mass, muscle strength, and health-related quality of life in kidney transplant recipients results of the TransplantLines Biobank & cohort study Open
Background and Aims Muscles play a vital role in nearly every aspect of daily living, and kidney transplant recipients (KTR) often experience reduced muscle mass and strength, potentially contributing to their diminished health-related qua…
View article: Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients
Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients Open
Kidney transplant recipients (KTRs) experience more fatigue, anxiety, and depressive symptoms and lower concentration and health-related quality of life (HRQoL) compared with the general population. Anemia is a potential cause that is well…
View article: Health-related quality of life is linked to the gut microbiome in kidney transplant recipients
Health-related quality of life is linked to the gut microbiome in kidney transplant recipients Open
View article: Rounding creatinine, cystatin C or both: impact on discordance group assignment and GFR-estimating equation performance
Rounding creatinine, cystatin C or both: impact on discordance group assignment and GFR-estimating equation performance Open
View article: Tolvaptan, Kidney Function Decline, and Potential Confounding by Muscle Wasting
Tolvaptan, Kidney Function Decline, and Potential Confounding by Muscle Wasting Open
View article: Creatine and creatinine quantified using nuclear magnetic resonance: A method validation study and clinical associations between circulating creatine and fatigue in kidney transplant recipients
Creatine and creatinine quantified using nuclear magnetic resonance: A method validation study and clinical associations between circulating creatine and fatigue in kidney transplant recipients Open
View article: Health-Related Quality of Life is Linked to the Gut Microbiome in Kidney Transplant Recipients
Health-Related Quality of Life is Linked to the Gut Microbiome in Kidney Transplant Recipients Open
Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. We investigate…
View article: Low selenium intake is associated with risk of all-cause mortality in kidney transplant recipients
Low selenium intake is associated with risk of all-cause mortality in kidney transplant recipients Open
Background Deficiency of the essential trace element selenium is common in kidney transplant recipients (KTR), potentially hampering antioxidant and anti-inflammatory defence. Whether this impacts the long-term outcomes of KTR remains unkn…
View article: Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients
Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients Open
Kidney transplant recipients (KTR) are at increased risk of cardiovascular mortality. We investigated whether, in KTR, post-transplantation copper status is associated with the risk of cardiovascular mortality and potential effect modifica…
View article: Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients
Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients Open
Introduction: In chronic kidney disease, proteinuria increases urinary copper excretion, inducing oxidative tubular damage and worsening kidney function. We investigated whether this phenomenon occurred in kidney transplant recipients (KTR…
View article: Dietary lithium intake, graft failure and mortality in kidney transplant recipients
Dietary lithium intake, graft failure and mortality in kidney transplant recipients Open
Background Long-term high-dose lithium therapy in bipolar disorder is known to adversely affect kidney function. However, recent animal studies have revealed that low amounts of lithium are beneficial for the kidney when it is damaged by e…
View article: Circulating FGF21 Concentration, Fasting Plasma Glucose, and the Risk of Type 2 Diabetes: Results From the PREVEND Study
Circulating FGF21 Concentration, Fasting Plasma Glucose, and the Risk of Type 2 Diabetes: Results From the PREVEND Study Open
Objective Fibroblast growth factor 21 (FGF21) is a peptide hormone synthesized by several organs and regulates, among others, energy homeostasis. In obesity, insulin resistance and type 2 diabetes (T2D), higher circulating FGF21 concentrat…