Alan Tan
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View article: Mobile-Based Smart Transport Route Optimization and Hazard Reporting System for San Juan
Mobile-Based Smart Transport Route Optimization and Hazard Reporting System for San Juan Open
The aim of this study is to develop a Mobile-Based Smart Transport Route Optimization and Hazard Reporting System that could improve navigation, minimize travel time, and increase road safety in San Juan City. The complex road system of th…
View article: Exceptional and durable response with pembrolizumab in a patient with microsatellite stable metastatic castrate-resistant prostate cancer: High tumor mutational burden and circulating tumor DNA clearance as predictive biomarkers
Exceptional and durable response with pembrolizumab in a patient with microsatellite stable metastatic castrate-resistant prostate cancer: High tumor mutational burden and circulating tumor DNA clearance as predictive biomarkers Open
Emerging biomarkers, such as tumor mutational burden and circulating tumor DNA (ctDNA), offer promising tools for identifying patients with prostate cancer who may benefit from immune checkpoint inhibitor therapy. This report describes an …
View article: Reevaluating the role of platinum-based chemotherapy in the evolving treatment landscape for patients with advanced urothelial carcinoma
Reevaluating the role of platinum-based chemotherapy in the evolving treatment landscape for patients with advanced urothelial carcinoma Open
Platinum-based chemotherapy has been the standard first-line (1L) treatment for advanced urothelial carcinoma (UC) for decades, based on the proven efficacy and established safety profiles of cisplatin- and carboplatin-based regimens. With…
View article: Association of Tumor-informed Circulating Tumor DNA Detectability Before and After Radical Cystectomy with Disease-free Survival in Patients with Bladder Cancer
Association of Tumor-informed Circulating Tumor DNA Detectability Before and After Radical Cystectomy with Disease-free Survival in Patients with Bladder Cancer Open
We found that outcomes for patients with muscle-invasive bladder cancer are strongly linked to detection of tumor DNA in blood samples. The results show the value of tumor-informed testing for tumor DNA in blood for decisions on the best t…
View article: Case report: Metastatic BRAF V600E–mutated adult Wilms’ tumor with robust response to BRAF/MEK inhibitor therapy
Case report: Metastatic BRAF V600E–mutated adult Wilms’ tumor with robust response to BRAF/MEK inhibitor therapy Open
Nephroblastoma or Wilms’ tumor (WT) is the most common pediatric renal malignancy but rare in adults. Treatment protocols for adults are typically extrapolated from pediatric guidelines, but there are no standard guidelines for adults due …
View article: 212P A phase Ib/II study of palazestrant (OP-1250) in combination with ribociclib in patients with estrogen receptor-positive human epidermal growth factor receptor 2-negative (ER+, HER2-) metastatic breast cancer
212P A phase Ib/II study of palazestrant (OP-1250) in combination with ribociclib in patients with estrogen receptor-positive human epidermal growth factor receptor 2-negative (ER+, HER2-) metastatic breast cancer Open
Palazestrant is a small molecule oral complete ER antagonist (CERAN) and selective ER degrader (SERD) that completely blocks ER-driven transcriptional activity. Palazestrant combined with ribociclib demonstrated activity in both ESR1-wt an…
View article: Liquid biopsy for renal cell carcinoma: A comprehensive review of techniques, applications, and future prospects
Liquid biopsy for renal cell carcinoma: A comprehensive review of techniques, applications, and future prospects Open
Liquid biopsy techniques have developed rapidly in recent years and demonstrated success in cancer detection, disease characterization, and ongoing disease monitoring. These components, including circulating tumor cells (CTCs), circulating…
View article: Perioperative Use of ctDNA to Guide Treatment for Urothelial Carcinoma: The Future is Now.
Perioperative Use of ctDNA to Guide Treatment for Urothelial Carcinoma: The Future is Now. Open
Muscle-invasive bladder cancer represents a potentially curable disease, yet often disease recurs and is ultimately fatal. Outcomes for patients with localized urothelial carcinoma are heterogeneous with some patients cured with surgery al…
View article: The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis
The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis Open
In complex mammals, the importance and host-specificity of microbial communities have been demonstrated through their positive effects on host immune fitness or performance. However, whether host metabolic physiology homeostasis depends on…
View article: Durable and dramatic response to checkpoint inhibition combined with <scp>COX</scp>‐2 inhibitor celecoxib in a patient with p16+ metastatic sinonasal undifferentiated carcinoma: A case study
Durable and dramatic response to checkpoint inhibition combined with <span>COX</span>‐2 inhibitor celecoxib in a patient with p16+ metastatic sinonasal undifferentiated carcinoma: A case study Open
Background Sinonasal undifferentiated carcinoma (SNUC) is an exceedingly rare head and neck malignancy. No consensus exists on treatment for metastatic disease. Case A 56‐year‐old female was diagnosed with SNUC after endorsing sinus conges…
View article: Durable and Dramatic Response to Checkpoint Inhibition Combined with COX-2 Inhibitor Celecoxib in a Patient with p16+ Metastatic Sinonasal Undifferentiated Carcinoma: A Case Study
Durable and Dramatic Response to Checkpoint Inhibition Combined with COX-2 Inhibitor Celecoxib in a Patient with p16+ Metastatic Sinonasal Undifferentiated Carcinoma: A Case Study Open
Background: Sinonasal undifferentiated carcinoma (SNUC) is an exceedingly rare head and neck malignancy. No consensus exists on treatment for metastatic disease. Case: A 56-year-old female was diagnosed with SNUC after endorsing sinus cong…
View article: Gut microbes and the liver circadian clock partition glucose and lipid metabolism
Gut microbes and the liver circadian clock partition glucose and lipid metabolism Open
Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mechanisms remai…
View article: 661 Initial results from a phase 1a/b study of IK-175, an oral AHR inhibitor, as a single agent and in combination with nivolumab in patients with advanced solid tumors and urothelial carcinoma
661 Initial results from a phase 1a/b study of IK-175, an oral AHR inhibitor, as a single agent and in combination with nivolumab in patients with advanced solid tumors and urothelial carcinoma Open
Background Aryl Hydrocarbon receptor (AHR) is a transcription factor activated by binding to ligands, including kynurenine, causing expression of immune modulating genes leading to immunosuppression. IK-175 is an oral, selective, small mol…
View article: Combination treatment of bilateral periocular sebaceous carcinomas with microsatellite instability with neoadjuvant pembrolizumab and Mohs surgery
Combination treatment of bilateral periocular sebaceous carcinomas with microsatellite instability with neoadjuvant pembrolizumab and Mohs surgery Open
This case highlights the successful use of pembrolizumab for neoadjuvant treatment of MMR‐deficient sebaceous carcinoma of bilateral eyelids to reduce tumour burden allowing smaller defect post‐Mohs surgery and better reconstructive outcom…
View article: Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism
Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism Open
Summary Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes also exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mec…
View article: 392 A phase 1a/b study of IK-175, an oral AHR inhibitor, alone and in combination with nivolumab in patients with locally dvanced or metastatic solid tumors and urothelial carcinoma
392 A phase 1a/b study of IK-175, an oral AHR inhibitor, alone and in combination with nivolumab in patients with locally dvanced or metastatic solid tumors and urothelial carcinoma Open
Background Aryl Hydrocarbon Receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells after binding to several endogenous and exogenous ligands, including kynurenine, generated from t…
View article: Phase I Study Protocol: NKTR-255 as Monotherapy or Combined with Daratumumab or Rituximab in Hematologic Malignancies
Phase I Study Protocol: NKTR-255 as Monotherapy or Combined with Daratumumab or Rituximab in Hematologic Malignancies Open
NKTR-255 is an investigational polyethylene glycol-modified recombinant human IL-15 (rhIL-15) receptor agonist, designed to improve the immunotherapeutic and anti-cancer benefit observed with rhIL-15 while circumventing the toxicities asso…
View article: 355 First-in-human phase I study of NKTR-255 in patients with relapsed/refractory hematologic malignancies
355 First-in-human phase I study of NKTR-255 in patients with relapsed/refractory hematologic malignancies Open
Background NKTR-255, an investigational IL-15Rα-dependent polymer-conjugated recombinant human IL-15 (rhIL-15) agonist, maintains the full spectrum of IL-15 biology and provides sustained pharmacodynamic (PD) responses without the need for…