Adrian Tire
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View article: Whole-miRNome sequencing: a panel for the targeted sequencing of all human miRNA genes
Whole-miRNome sequencing: a panel for the targeted sequencing of all human miRNA genes Open
Interest in the genetic variation of noncoding genomic elements, including microRNAs (miRNAs), is growing, and several mutations in miRNA genes implicated in human diseases, including cancer, have already been detected. However, the lack o…
View article: miRNA gene mutations commonly disrupt the proper functioning of miRNA genes
miRNA gene mutations commonly disrupt the proper functioning of miRNA genes Open
A growing number of mutations are being identified in the noncoding genome, including miRNA genes. However, little is known about the consequences of these mutations and how harmful they are to the functioning of miRNA genes. To evaluate t…
View article: Whole-miRNome sequencing (WMS) - a panel for targeted sequencing of all human miRNA genes
Whole-miRNome sequencing (WMS) - a panel for targeted sequencing of all human miRNA genes Open
There is a growing interest in the genetic variation of noncoding genomic elements, including miRNAs, and several mutations in miRNA genes implicated in human diseases, including cancer, have already been detected. However, the lack of ded…
View article: Mutations in the miR-142 gene are not common in myeloproliferative neoplasms
Mutations in the miR-142 gene are not common in myeloproliferative neoplasms Open
Recent data indicate that MIR142 is the most frequently mutated miRNA gene and one of the most frequently mutated noncoding elements in all cancers, with mutations occurring predominantly in blood cancers, especially diffuse large B-cell l…