Adrian W. Moore
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The fly brain lands in Tokyo: A report on the 3rd Asia Pacific <i>Drosophila</i> Neurobiology Conference Open
The third Asia Pacific Drosophila Neurobiology Conference (APDNC3) was held in the Wako Campus of RIKEN in Tokyo, Japan, from February 27th to March 1st, 2024. While APDNC2 was held in Taiwan in 2019, the global coronavirus pandemic enforc…
View article: Multi-scale Stochastic Generation of Labelled Microscopy Images for Neuron Segmentation
Multi-scale Stochastic Generation of Labelled Microscopy Images for Neuron Segmentation Open
International audience
6ER-021 Opioid-sparing strategies for discharge analgesia prescribing in non-complex surgeries – a missed opportunity Open
Background and Importance Opioids are an integral element of post-operative management for moderate to strong pain. Despite their effectiveness they are associated with a range of adverse effects and excessive opioid prescribing has contri…
Study of Dendrite Differentiation Using<i>Drosophila</i>Dendritic Arborization Neurons Open
Neurons receive, process, and integrate inputs. These operations are organized by dendrite arbor morphology, and the dendritic arborization (da) neurons of the Drosophila peripheral sensory nervous system are an excellent experimental mode…
View article: CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate Open
CUX2 gene encodes a transcription factor that controls neuronal proliferation, dendrite branching and synapse formation, locating at the epilepsy-associated chromosomal region 12q24 that we previously identified by a genome-wide associatio…
Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes Open
Stem cells that indirectly generate differentiated cells through intermediate progenitors drives vertebrate brain evolution. Due to a lack of lineage information, how stem cell functionality, including the competency to generate intermedia…
Author response: Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Stem cells that indirectly gene…
Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity Open
Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and th…
Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration Open
In neural precursors, cell cycle regulators simultaneously control both progression through the cell cycle and the probability of a cell fate switch. Precursors act in lineages, where they transition through a series of cell types, each of…
Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites Open
A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. Conserved among both invertebrates and vertebrates, axons contain exclusively ‘plus-end-out’ microtubule…
Growth Cone-Localized Microtubule Organizing Center Establishes Microtubule Orientation in Dendrites Open
A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. Conserved among both invertebrates and vertebrates, axons contain exclusively “plus-end-out” microtubule…
Dendritic actin delivery service Open
The mechanisms by which the actin cytoskeleton regulates dendritic branching are not fully understood. Nithianandam and Chien (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711136) discover actin blobs, new structures that mediate dyn…
View article: <i>Drosophila</i> Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling
<i>Drosophila</i> Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling Open
The pattern of the Drosophila melanogaster adult wing is heavily influenced by the expression of proteins that dictate cell fate decisions between intervein and vein during development. dSRF (Blistered) expression in specific regions of th…
Microtubule nucleation and organization in dendrites Open
Dendrite branching is an essential process for building complex nervous systems. It determines the number, distribution and integration of inputs into a neuron, and is regulated to create the diverse dendrite arbor branching patterns chara…