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View article: A Randomised-Controlled Study Demonstrates That Diet Can Contribute to the Clinical Management of Feline Atopic Skin Syndrome (FASS)
A Randomised-Controlled Study Demonstrates That Diet Can Contribute to the Clinical Management of Feline Atopic Skin Syndrome (FASS) Open
Feline atopic skin syndrome (FASS) is a common inflammatory and highly pruritic skin condition. It typically manifests according to one or more of four different clinical lesion patterns: miliary dermatitis, self-induced alopecia, head and…
View article: Glycyrrhizin intake higher than the current international guidelines has no detectable hypermineralocorticoid‐like effect in dogs
Glycyrrhizin intake higher than the current international guidelines has no detectable hypermineralocorticoid‐like effect in dogs Open
Glycyrrhizin‐enriched extracts from licorice root are associated with numerous health benefits and are widely used in phytotherapy. There is evidence that ingesting glycyrrhizin beyond threshold concentrations can impact the metabolism of …
View article: A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs Open
Background Like its human counterpart, canine atopic dermatitis (cAD) is a chronic relapsing condition; thus, most cAD-affected dogs will require lifelong treatment to maintain an acceptable quality of life. A potential intervention is mod…
View article: Impacts to canine dermal microbiota associated with repeated bathing
Impacts to canine dermal microbiota associated with repeated bathing Open
Introduction Working dogs routinely operate in environmental conditions which may necessitate daily bathing to remove contaminants or soilage. The impacts of frequent or repeated bathing on the canine dermal microbiota are unknown. The obj…
View article: Additional file 1 of A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
Additional file 1 of A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs Open
Additional file 1: Figure S1. The cohort of Shiba Inu dogs tested in this study (a). Twelve skin swab samples and a faecal sample were collected from each dog in each group, resulted in a total of 12 ´ (10+ 10+ 10 + 20) = 600 skin swab sam…
View article: A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs Open
Background Like its human counterpart, canine atopic dermatitis (cAD) is a chronic relapsing condition; thus, most cAD-affected dogs will require lifelong treatment to maintain an acceptable quality of life. A potential intervention is mod…
View article: The Linoleic Acid Content of the Stratum Corneum of Ichthyotic Golden Retriever Dogs Is Reduced as Compared to Healthy Dogs and a Significant Part Is Oxidized in Both Free and Esterified Forms
The Linoleic Acid Content of the Stratum Corneum of Ichthyotic Golden Retriever Dogs Is Reduced as Compared to Healthy Dogs and a Significant Part Is Oxidized in Both Free and Esterified Forms Open
Golden Retrievers may suffer from Pnpl1-related inherited ichthyosis. Our study shows that in the stratum corneum (SC) of ichthyotic dogs, linoleic acid (LA) is also present in the form of 9-keto-octadecadienoic acid (9-KODE) instead of th…
View article: A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine‐month controlled study
A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine‐month controlled study Open
Background Canine atopic dermatitis (cAD) is a common chronic relapsing pruritic skin disease for which management commonly relies on life‐long use of immunomodulatory drugs. A number of the medications used are associated with adverse eff…
View article: Association of the canine <i>ATP7A</i> and <i>ATP7B</i> with hepatic copper accumulation in Dobermann dogs
Association of the canine <i>ATP7A</i> and <i>ATP7B</i> with hepatic copper accumulation in Dobermann dogs Open
Background Hepatic copper accumulation causes chronic hepatitis in dogs. Mutations in the copper transporters ATP7A and ATP7B were, respectively, associated with attenuation and enhancement of hepatic copper concentrations in Labrador Retr…
View article: Linoleate-enriched diet increases both linoleic acid esterified to omega hydroxy very long chain fatty acids and free ceramides of canine stratum corneum without effect on protein-bound ceramides and skin barrier function
Linoleate-enriched diet increases both linoleic acid esterified to omega hydroxy very long chain fatty acids and free ceramides of canine stratum corneum without effect on protein-bound ceramides and skin barrier function Open
Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on canine stratum corneum (SC) lipids was stu…
View article: Increased dietary intake of tyrosine upregulates melanin deposition in the hair of adult black-coated dogs
Increased dietary intake of tyrosine upregulates melanin deposition in the hair of adult black-coated dogs Open
The principle determinant of melanin derived hair colour and patterning in mammals is genetic, but environmental factors are now thought to play a role. It has been shown that the concentration of melanins in cat hair is influenced by the …
View article: Gene expression patterns in the progression of canine copper-associated chronic hepatitis
Gene expression patterns in the progression of canine copper-associated chronic hepatitis Open
Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes disease. The Labrador retriever do…
View article: Nutritional components can influence hair coat colouration in white dogs
Nutritional components can influence hair coat colouration in white dogs Open
Summary Hair colouration in animals is controlled primarily by inherited factors, with a complex set of genes and genetic variants determining phenotypic expression. The colours in the hair shaft are created initially by the melanocyte cel…
View article: The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders Open
The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving ATP7A, is a fatal neurodegenerat…
View article: Dietary Management of Labrador Retrievers with Subclinical Hepatic Copper Accumulation
Dietary Management of Labrador Retrievers with Subclinical Hepatic Copper Accumulation Open
Background Genetic and environmental factors, including dietary copper intake, contribute to the pathogenesis of copper‐associated hepatitis in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumu…
View article: The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers
The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers Open
We investigated the effect of feeding a skin barrier function-augmenting diet early in dogs' lives on the appearance of clinical signs associated with canine atopic dermatitis. Pregnant bitches (starting 5 weeks after mating) and their sub…