Adrian Young
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View article: Racial and Ethnic Comparisons in Satisfaction with Services Provided by the Special Supplemental Nutrition Program for Women, Infants, and Children in California
Racial and Ethnic Comparisons in Satisfaction with Services Provided by the Special Supplemental Nutrition Program for Women, Infants, and Children in California Open
Understanding satisfaction of nutrition education and other services provided in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) is needed to ensure the program is responsive to the needs of diverse populat…
View article: An investigation into the impact of deleting one copy of the <i>glutaredoxin-2</i> gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet
An investigation into the impact of deleting one copy of the <i>glutaredoxin-2</i> gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet Open
Our group recently documented that male mice containing a deletion for one copy of the glutaredoxin-2 (Grx2) gene were completely protected from developing diet-induced obesity (DIO). Objectives: Here, we conducted a similar investigation …
View article: The role of glutaredoxin-2 in the modulation of fat metabolism and ROS production in skeletal muscle mitochondria
The role of glutaredoxin-2 in the modulation of fat metabolism and ROS production in skeletal muscle mitochondria Open
Protein S-glutathionylation (PGLU) reactions in mitochondria, catalyzed by glutaredoxin-2 (Grx2), have been shown to regulate carbon catabolism, oxidative phosphorylation and reactive oxygen species (ROS) production in response to changes …
View article: Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2
Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2 Open
Our group recently published a study demonstrating that deleting the gene encoding the matrix thiol oxidoreductase, glutaredoxin-2 (GRX2), alters the bioenergetics of mitochondria isolated from male C57BL/6N mice. Here, we conducted a simi…
View article: Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle
Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle Open
Aims: The aim of this study was to determine whether deleting the gene encoding glutaredoxin-2 (GRX2) could protect mice from diet-induced weight gain. Results: Subjecting wild-type littermates to a high fat diet (HFD) induced a significan…
View article: Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases Open
It has been reported that mitochondria can contain up to 12 enzymatic sources of reactive oxygen species (ROS). A majority of these sites include flavin-dependent respiratory complexes and dehydrogenases that produce a mixture of superoxid…
View article: Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake
Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake Open
Protein S-glutathionylation is a reversible redox modification that regulates mitochondrial metabolism and reactive oxygen species (ROS) production in liver and cardiac tissue. However, whether or not it controls ROS release from skeletal …
View article: Mutter Courage und ihre Erbe: Mother Courage and her Legacy
Mutter Courage und ihre Erbe: Mother Courage and her Legacy Open
Mother Courage and Her Children is a play that has seemingly lost its place in the world. Brecht’s original intent was to use verfremdungseffekt to distance his audience from the violence that had swallowed them and use that distance to le…
View article: Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria
Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria Open
Here, we found that formate, an essential one‐carbon metabolite, activates superoxide ( )/hydrogen peroxide (H 2 O 2 ) release from mitochondria. Sodium formate (30 μ m ) induces a significant increase in /H 2 O 2 production in liver mitoc…
View article: Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria
Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria Open
Here, we report that choline and dimethylglycine can stimulate reactive oxygen species ( ROS ) production in liver mitochondria. Choline stimulated O 2 ˙ − /H 2 O 2 formation at a concentration of 5 μ m . We also observed that Complex II a…