Adriana Cassaro
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View article: FZD6 triggers Wnt–signalling driven by WNT10B <sup>IVS1</sup> expression and highlights new targets in T‐cell acute lymphoblastic leukemia
FZD6 triggers Wnt–signalling driven by WNT10B <sup>IVS1</sup> expression and highlights new targets in T‐cell acute lymphoblastic leukemia Open
Wnt/Fzd signaling has been implicated in hematopoietic stem cell maintenance and in acute leukemia establishment. In our previous work, we described a recurrent rearrangement involving the WNT10B locus (WNT10B R ), characterized by the exp…
View article: The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche Open
Notch and Wnt signaling are highly conserved intercellular communication pathways involved in developmental processes, such as hematopoiesis. Even though data from literature support a role for these two pathways in both physiological hema…
View article: Prospective Evaluation of a Continuation Therapy with Midostaurin in Adult Patients with Core-Binding Factor Leukemia and Integrated Genetic Analysis: A Multi Center Phase II Study. Preliminary Results
Prospective Evaluation of a Continuation Therapy with Midostaurin in Adult Patients with Core-Binding Factor Leukemia and Integrated Genetic Analysis: A Multi Center Phase II Study. Preliminary Results Open
Genetic and Clinical Background: The clinical outcome of Core Binding Factor Leukemia (CBFL) seems influenced by the mutational status of KIT. In fact, several retrospective studies, in addition to our own, as well as a systematic review, …
View article: Small Molecule Inhibitors of Microenvironmental Wnt/β-Catenin Signaling Enhance the Chemosensitivity of Acute Myeloid Leukemia
Small Molecule Inhibitors of Microenvironmental Wnt/β-Catenin Signaling Enhance the Chemosensitivity of Acute Myeloid Leukemia Open
Wnt/β-catenin signaling has been reported in Acute Myeloid leukemia, but little is known about its significance as a prognostic biomarker and drug target. In this study, we first evaluated the correlation between expression levels of Wnt m…
View article: Prognostic role in common clinical practice of neutrophil-to-lymphocyte ratio in unselected bladder cancer
Prognostic role in common clinical practice of neutrophil-to-lymphocyte ratio in unselected bladder cancer Open
View article: TNIK (TRAF2 and NCK interacting kinase)
TNIK (TRAF2 and NCK interacting kinase) Open
The serine/threonine kinase Traf2- and Nck interacting kinase (TNIK), is a member of the germinal center kinase (GCK) family that has been reported to have an important role in the regulation of Jun N-terminal kinase pathway (JNK) activati…
View article: PYGO2 (pygopus family PHD finger 2)
PYGO2 (pygopus family PHD finger 2) Open
PYGO2 is member of a conserved family of plant homeo domain (PHD)-containing proteins and takes part in a wide range of developmental and transcriptional processes. The most relevant role played by PYGO2 is in Wnt signaling pathway, where …
View article: FZD4 (frizzled class receptor 4)
FZD4 (frizzled class receptor 4) Open
Fzd4 is a receptor for Wnt proteins, belonging to the frizzled receptors family. Its stimulation can activate both Wnt/β-catenin canonical and Wnt/Ca2+ non canonical pathways. This receptor plays an important role in the development p…
View article: In reply to Schäfer <i>et al</i>: new evidence on the role of endothelin‐1 axis as a potential therapeutic target in multiple myeloma
In reply to Schäfer <i>et al</i>: new evidence on the role of endothelin‐1 axis as a potential therapeutic target in multiple myeloma Open
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
View article: Endothelin‐1 receptor blockade as new possible therapeutic approach in multiple myeloma
Endothelin‐1 receptor blockade as new possible therapeutic approach in multiple myeloma Open
Summary New effective treatments are needed to improve outcomes for multiple myeloma ( MM ) patients. Receptors with restricted expression on plasma cells ( PC s) represent attractive new therapeutic targets. The endothelin‐1 ( EDN 1) axis…
View article: Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions
Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions Open
Mesenchymal stromal cells (MSCs) are multipotent cells, immunomodulatory stem cells that are currently used for regenerative medicine and treatment of a number of inflammatory diseases, thanks to their ability to significantly influence ti…
View article: Identification of granulocytic myeloid-derived suppressor cells (G-MDSCs) in the peripheral blood of Hodgkin and non-Hodgkin lymphoma patients
Identification of granulocytic myeloid-derived suppressor cells (G-MDSCs) in the peripheral blood of Hodgkin and non-Hodgkin lymphoma patients Open
Human granulocytic myeloid-derived suppressor cells (G-MDSCs) have been described as low-density immunosuppressive CD66b+CD33dimHLA-DR-granulocytes that co-purify with mononuclear cells after density gradient centrifugation of blood from c…
View article: Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia
Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia Open
Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemore…