Adriana Di Benedetto
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View article: Surface Co-presentation of BMP-2 and integrin selective ligands at the nanoscale favors α5β1 integrin-mediated adhesion
Surface Co-presentation of BMP-2 and integrin selective ligands at the nanoscale favors α5β1 integrin-mediated adhesion Open
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle …
View article: Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes Open
Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniq…
View article: Osteogenic and Chondrogenic Potential of the Supramolecular Aggregate T-LysYal®
Osteogenic and Chondrogenic Potential of the Supramolecular Aggregate T-LysYal® Open
Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior s…
View article: Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion
Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion Open
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle …
View article: Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion
Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion Open
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle …
View article: Erratum to “Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and <i>α</i>V<i>β</i>3 Expression”
Erratum to “Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and <i>α</i>V<i>β</i>3 Expression” Open
[This corrects the article DOI: 10.1155/2018/6958713.].
View article: Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and <i>α</i>V<i>β</i>3 Expression
Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and <i>α</i>V<i>β</i>3 Expression Open
Vitamin D (Vit D) by means of its biological active form, 1 α ,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect o…
View article: High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability
High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability Open
Cells from dental tissues have a mesenchymal stem cell (MSC) phenotype, are multipotent and can differentiate into osteoblastic cells, as we have previously found. MSCs, due to their tumor‑homing ability, are currently being used as cell‑b…
View article: Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells
Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Open
Bone loss and fractures are consequences of aging, diseases or traumas. Furthermore the increased number of aged people, due to the rise of life expectancy, needs more strategies to limit the bone loss and regenerate the lost tissue, ameli…
View article: Impairment of Bone Remodeling in <i>LIGHT/TNFSF14</i>-Deficient Mice
Impairment of Bone Remodeling in <i>LIGHT/TNFSF14</i>-Deficient Mice Open
Multiple cytokines produced by immune cells induce remodeling and aid in maintaining bone homeostasis through differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. Here, we investigate bone remodeling controlled by th…
View article: LIGHT/TNFSF14 affects basal bone remodeling
LIGHT/TNFSF14 affects basal bone remodeling Open
LIGHT (TNFSF14), expressed by different cells of the immune system, binds two trans-membrane receptors: HVEM and LTβR. It is over-expressed in erosive rheumatoid arthritis and lytic myeloma-bone disease and controversial data have been pub…
View article: Bone Regeneration Induced by Bone Porcine Block with Bone Marrow Stromal Stem Cells in a Minipig Model of Mandibular “Critical Size” Defect
Bone Regeneration Induced by Bone Porcine Block with Bone Marrow Stromal Stem Cells in a Minipig Model of Mandibular “Critical Size” Defect Open
Introduction . Adding stem cells to biodegradable scaffolds to enhance bone regeneration is a valuable option. Different kinds of stem cells with osteoblastic activity were tested, such as bone marrow stromal stem cells (BMSSCs). Aim . To …
View article: NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs
NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs Open
Mesenchymal stem cells (MSCs) have been identified in human dental tissues. Dental pulp stem cells (DPSCs) were classified within MSC family, are multipotent, can be isolated from adult teeth, and have been shown to differentiate, under pa…
View article: Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues
Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues Open
1 α ,25‐Dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the active metabolite of vitamin D (Vit D), increases intestinal absorption of calcium and phosphate, maintaining a correct balance of bone remodeling. Vit D has an anabolic effect on the ske…
View article: Functions of vasopressin and oxytocin in bone mass regulation
Functions of vasopressin and oxytocin in bone mass regulation Open
Significance We show that oxytocin and vasopressin, which are released from the posterior pituitary gland to regulate lactation and water balance, respectively, are potent regulators of skeletal integrity. Using genetically modified mice a…
View article: Osteogenic differentiation of mesenchymal stem cells from dental bud: Role of integrins and cadherins
Osteogenic differentiation of mesenchymal stem cells from dental bud: Role of integrins and cadherins Open
Several studies have reported the beneficial effects of mesenchymal stem cells (MSCs) in tissue repair and regeneration. New sources of stem cells in adult organisms are continuously emerging; dental tissues have been identified as a sourc…
View article: The myokine irisin increases cortical bone mass
The myokine irisin increases cortical bone mass Open
Significance Although exercise is a well known and potent stimulus for new bone formation, and weightlessness or muscle loss characteristically cause bone loss, it has remained unclear how muscle talks to bone, despite their close proximit…
View article: Integrins and Cadherins could be important regulators of osteogenic differentiation and bone formation in dental stem cells
Integrins and Cadherins could be important regulators of osteogenic differentiation and bone formation in dental stem cells Open
Regenerative medicine aims to translate the regeneration of tissues and organs into clinical application. Numerous studies have reported beneficial effects of Adult stem cells therapy in the treatment of disease and disabilities. New sourc…
View article: Shedding LIGHT on bone cell differentiation and Multiple Myeloma-bone disease
Shedding LIGHT on bone cell differentiation and Multiple Myeloma-bone disease Open
LIGHT/TNFSF14, a member of the tumor necrosis factor superfamily, is known to play a major role in T-cell homeostasis, whereas its effect on osteoclastogenesis is controversial. Here, we investigated LIGHT involvement in bone cell differen…
View article: Human Myeloma Cell Lines Induce Osteoblast Downregulation of CD99 Which Is Involved in Osteoblast Formation and Activity
Human Myeloma Cell Lines Induce Osteoblast Downregulation of CD99 Which Is Involved in Osteoblast Formation and Activity Open
CD99 is a transmembrane glycoprotein expressed in physiological conditions by cells of different tissues, including osteoblasts (OBs). High or low CD99 levels have been detected in various pathological conditions, and the supernatant of so…