Adriana E. Rosato
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View article: Beyond <i>mecA</i> : a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA
Beyond <i>mecA</i> : a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA Open
High-level resistance to ceftaroline, a fifth-generation β-lactam critical for treating methicillin-resistant Staphylococcus aureus (MRSA), is an emerging threat to global health. While resistance is traditionally attributed to mecA -media…
View article: Clinical Relevance of PCR Versus Culture in Urinary Tract Infections Diagnosis: Quantification Cycle as a Predictor of Bacterial Load
Clinical Relevance of PCR Versus Culture in Urinary Tract Infections Diagnosis: Quantification Cycle as a Predictor of Bacterial Load Open
Background: Unambiguous clinical interpretation of PCR results for urinary tract infections (UTIs) remains a challenge. Here we compare and correlate multiplex qPCR results (quantification cycle values) with traditional microbial culture r…
View article: Leveraging strain competition to address antimicrobial resistance with microbiota therapies
Leveraging strain competition to address antimicrobial resistance with microbiota therapies Open
The enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as…
View article: P-1501. Intracellular Activity of Delafloxacin Against Small Colony Variant <i>Staphylococcus aureus</i>
P-1501. Intracellular Activity of Delafloxacin Against Small Colony Variant <i>Staphylococcus aureus</i> Open
Background Small colony variants (SCVs) of Staphylococcus aureus (SA) have significant intracellular persistence. Fluoroquinolones demonstrate intracellular activity and are often utilized to treat SCVs. Delafloxacin is a fluroquinolone wi…
View article: Clinical outcome of combination of vancomycin and ceftaroline versus vancomycin monotherapy for treatment of methicillin resistant Staphylococcus aureus bloodstream infection
Clinical outcome of combination of vancomycin and ceftaroline versus vancomycin monotherapy for treatment of methicillin resistant Staphylococcus aureus bloodstream infection Open
The results of this study are limited by a retrospective observational design; however, combination of vancomycin and ceftaroline for MRSA bacteraemia was not associated with lower bacteraemia recurrence or mortality compared to vancomycin…
View article: Virulence Potential of Biofilm-Producing Staphylococcus pseudintermedius, Staphylococcus aureus and Staphylococcus coagulans Causing Skin Infections in Companion Animals
Virulence Potential of Biofilm-Producing Staphylococcus pseudintermedius, Staphylococcus aureus and Staphylococcus coagulans Causing Skin Infections in Companion Animals Open
Coagulase-positive staphylococci (CoPS) account for most bacteria-related pyoderma in companion animals. Emergence of methicillin-resistant strains of Staphylococcus pseudintermedius (MRSP), Staphylococcus aureus (MRSA) or Staphylococcus c…
View article: Rapid detection of the widely circulating B.1.617.2 (Delta) SARS-CoV-2 variant
Rapid detection of the widely circulating B.1.617.2 (Delta) SARS-CoV-2 variant Open
The emergence of the B.1.617.2 (Delta) variant of the severe acute syndrome coronavirus (SARS-CoV-2) that emerged in 2019 (COVID-19), resulted in a surge of cases in India and has expanded and been detected across the world, including in t…
View article: Staphylococcus pseudintermedius’s PBP4 Is Directly Associated with the Dissociated Oxacillin and Cefoxitin Phenotype
Staphylococcus pseudintermedius’s PBP4 Is Directly Associated with the Dissociated Oxacillin and Cefoxitin Phenotype Open
Staphylococcus pseudintermedius is an important pathogen responsible for infections in dogs and in humans. The emergence and dissemination of methicillin-resistant S. pseudintermedius (MRSP) and the multidrug resistance frequently seen in …
View article: Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains
Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains Open
Background The cyclic anionic lipopeptide daptomycin is used in the treatment of severe infections caused by Gram-positive pathogens, including MRSA. Daptomycin resistance, although rare, often results in treatment failure. Paradoxically, …
View article: Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus
Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus Open
Certain methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit β-lactam susceptibility in vitro , ex vivo , and in vivo in the presence of NaHCO 3 (NaHCO 3 -responsive MRSA). Here, we investigate the impact of NaHCO 3 on factor…
View article: Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA
Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA Open
Chronic airways infection with methicillin-resistant Staphylococcus aureus (MRSA) is associated with worse respiratory disease cystic fibrosis (CF) patients. Ceftaroline is a cephalosporin that inhibits the penicillin-binding protein (PBP2…
View article: Carotenogenesis of<i>Staphylococcus aureus</i>: new insights and impact on membrane biophysical properties
Carotenogenesis of<i>Staphylococcus aureus</i>: new insights and impact on membrane biophysical properties Open
Staphyloxanthin (STX) is a saccharolipid derived from a carotenoid in Staphylococcus aureus involved in oxidative-stress tolerance and antimicrobial peptide resistance. In this work, a targeted metabolomics and biophysical study was carrie…
View article: Characterization of the First<i>mec</i>A-Positive Multidrug-Resistant<i>Staphylococcus pseudintermedius</i>Isolated from an Argentinian Patient
Characterization of the First<i>mec</i>A-Positive Multidrug-Resistant<i>Staphylococcus pseudintermedius</i>Isolated from an Argentinian Patient Open
Staphylococcus pseudintermedius is commonly associated with colonization or infection in dogs, and was identified as a novel species within the genus Staphylococcus in 2006. Methicillin resistance emerged in S. pseudintermedius during the …
View article: Tedizolid is a promising antimicrobial option for the treatment of <i>Staphylococcus aureus</i> infections in cystic fibrosis patients
Tedizolid is a promising antimicrobial option for the treatment of <i>Staphylococcus aureus</i> infections in cystic fibrosis patients Open
Background Tedizolid is a protein synthesis inhibitor in clinical use for the treatment of Gram-positive infections. Pulmonary MRSA infections are a growing problem in patients with cystic fibrosis (CF) and the efficacy of tedizolid-based …
View article: Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina
Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina Open
MRSP could be a threat to animal health due to it concerning level of antimicrobial resistance. Our study highlights genetic and epidemiological aspects of multidrug-resistant MRSP strains from Argentina showing high degree of correlation …
View article: VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> Infection
VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> Infection Open
Methicillin-resistant S. aureus continues to develop resistance to antimicrobials, including those in current clinical use as daptomycin (DAP). Resistance to DAP arises by mutations in cell membrane and cell wall genes and/or upregulation …
View article: Development of multidrug resistance in staphylococci driven by efflux
Development of multidrug resistance in staphylococci driven by efflux Open
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View article: Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients
Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients Open
Methicillin-resistant Staphylococcus aureus (MRSA) acquisition in cystic fibrosis (CF) patients confers a clinical outcome worse than that in non-CF patients with an increased rate of declined lung function. Telavancin, an approved lipogly…
View article: Activity of Telavancin against <i>S. aureus</i> isolated from cystic fibrosis patients including those with decreased susceptibility to Ceftaroline
Activity of Telavancin against <i>S. aureus</i> isolated from cystic fibrosis patients including those with decreased susceptibility to Ceftaroline Open
Methicillin-resistant Staphylococcus aureus (MRSA) acquisition in cystic fibrosis (CF) patients confers a worse clinical outcome with increased rate of declined lung function. Telavancin, an approved lipoglycopeptide used to treat infectio…
View article: Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost
Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost Open
Daptomycin remains as one of the main treatment options for Methicillin-Resistant Staphylococcus aureus (MRSA). Sporadic resistance cases reported in patients treated with either daptomycin or glycopeptides are a growing concern. In a prev…
View article: Combination Antibiotic Exposure Selectively Alters the Development of Vancomycin Intermediate Resistance in Staphylococcus aureus
Combination Antibiotic Exposure Selectively Alters the Development of Vancomycin Intermediate Resistance in Staphylococcus aureus Open
Invasive methicillin-resistant Staphylococcus aureus (MRSA) treated with vancomycin (VAN) is associated with reduced VAN susceptibility and treatment failure. VAN combination therapy is one strategy to improve response, but comprehensive a…
View article: Molecular Bases Determining Daptomycin Resistance-Mediated Resensitization to β-Lactams (Seesaw Effect) in Methicillin-Resistant Staphylococcus aureus
Molecular Bases Determining Daptomycin Resistance-Mediated Resensitization to β-Lactams (Seesaw Effect) in Methicillin-Resistant Staphylococcus aureus Open
Antimicrobial resistance is recognized as one of the principal threats to public health worldwide, yet the problem is increasing. Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains are among the most difficult …
View article: Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs
Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs Open
Klebsiella pneumoniae strains producing K. pneumoniae carbapenemase (KPC) cause serious infections in debilitated and immunocompromised patients and are associated with prolonged hospital stays and increased mortality rates. Daptomycin is …