Adriana Elena Bulboacă
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View article: Determinants of Outcome Variability in Ischemic Stroke: A Focus on Routinely Collected Biomarkers
Determinants of Outcome Variability in Ischemic Stroke: A Focus on Routinely Collected Biomarkers Open
Ischemic stroke remains a leading cause of mortality and disability, with proinflammatory, metabolic, and oxidative stress-related factors contributing to outcome variability. We conducted a retrospective cross-sectional study of 124 conse…
View article: Proinflammatory Risk Factors in Patients with Ischemic Stroke: A Systematic Review and Meta-Analysis
Proinflammatory Risk Factors in Patients with Ischemic Stroke: A Systematic Review and Meta-Analysis Open
Ischemic stroke is a leading cause of disability worldwide, often triggered by atherothrombotic or embolic events. A growing body of evidence highlights the role of neuroinflammation as a central mechanism in post-stroke damage, influenced…
View article: Therapeutic Effects of Lavender Oil on Streptozotocin-Induced Diabetes Mellitus and Experimental Thrombosis
Therapeutic Effects of Lavender Oil on Streptozotocin-Induced Diabetes Mellitus and Experimental Thrombosis Open
Diabetes mellitus is a metabolic disorder associated with oxidative stress, inflammation, and coagulation disturbances, which contribute to microvascular and macrovascular complications. We evaluated the therapeutic effects of lavender oil…
View article: Distinguishing subclinical from clinical keratoconus by corneal measurements
Distinguishing subclinical from clinical keratoconus by corneal measurements Open
Purpose The study aimed to determine the stability of topographic and tomographic indices measured with Pentacam and to evaluate the biomechanical parameters measured with Corvis ST in the diagnosis of subclinical keratoconus (sKCN) and cl…
View article: Age-Inclusive Healthcare Sustainability: Romania’s Regulatory and Initiatives Landscape in the European Union Context
Age-Inclusive Healthcare Sustainability: Romania’s Regulatory and Initiatives Landscape in the European Union Context Open
Sustainable healthcare is “healthcare that is economical and has a positive impact on society”. Considering the definition of sustainable healthcare and the increase in life expectancy, the healthcare system is expected to face an increase…
View article: Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis
Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis Open
Antinociceptive, sedative, anti-inflammatory, and antioxidant effects of lavender oil (LO) have been documented. The aim of our study was to evaluate the adjuvant effects of pretreatment with LO compared to standard treatment (low molecula…
View article: Zingiber officinale Root Capsule Extract Synergistically Enhance the Anti-Inflammatory Effects of Diclofenac Sodium in Experimental Acute Inflammation
Zingiber officinale Root Capsule Extract Synergistically Enhance the Anti-Inflammatory Effects of Diclofenac Sodium in Experimental Acute Inflammation Open
The present study aimed to evaluate the anti-inflammatory effects of ginger (Zingiber officinale) root capsule extract (GRCE) in doses of 100 mg/kg b.w. (body weight) and 200 mg/kg b.w. alone and in combination with a low dose (5 mg/kg b.w…
View article: Editorial: Progressive keratoconus: insights into etiopathogenesis, diagnosis, and treatment
Editorial: Progressive keratoconus: insights into etiopathogenesis, diagnosis, and treatment Open
EDITORIAL article Front. Med., 13 November 2023Sec. Ophthalmology Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1302625
View article: Nitric Oxide/Nitric Oxide Synthase System in the Pathogenesis of Neurodegenerative Disorders—An Overview
Nitric Oxide/Nitric Oxide Synthase System in the Pathogenesis of Neurodegenerative Disorders—An Overview Open
Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule implicated in many central and benefic molecular pathways and has a well-established role in the function of the central nervous system, as numerous …
View article: Ginger (Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation
Ginger (Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation Open
Our study aimed to evaluate the analgesic and antioxidant effects of ginger (Zingiber officinale) root capsule extract (GRCE) in addition to diclofenac (D) sodium treatment in carrageenan-induced acute inflammation (AI). Seven groups of ei…
View article: Long term visual outcomes in cataract surgery with bilateral implantation of the Extended Depth of Focus Intraocular Lens – Mini Well Ready type
Long term visual outcomes in cataract surgery with bilateral implantation of the Extended Depth of Focus Intraocular Lens – Mini Well Ready type Open
Purpose: To evaluate the refractive results, visual outcomes and patients' satisfaction of a new extended depth-of-focus (EDOF) intraocular lens (IOL). Setting: Oculens Clinic, Cluj-Napoca, Romania. Design: Retrospective, single-center, ob…
View article: Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation
Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation Open
The present study evaluated the anti-inflammatory and analgesic effects of conventional curcumin (cC) and curcumin nanoparticles (nC) associated with diclofenac sodium (D) in experimental acute inflammation (AI) induced by carrageenan admi…
View article: Performances of Corneal Topography and Tomography in the Diagnosis of Subclinical and Clinical Keratoconus
Performances of Corneal Topography and Tomography in the Diagnosis of Subclinical and Clinical Keratoconus Open
Aim The purpose of the study was to assess the efficacy of topographical and tomographical indices given by the Pentacam (pachymetric, tomopetric, and aberometric) in clinical and subclinical keratoconus (KCN) diagnosis. Material and Metho…
View article: Protective Effect of Liposomal Epigallocatechin-Gallate in Experimental Gentamicin-Induced Hepatotoxicity
Protective Effect of Liposomal Epigallocatechin-Gallate in Experimental Gentamicin-Induced Hepatotoxicity Open
Our study aimed to assess the effect of liposomal epigallocatechin-gallate (LEGCG) compared with epigallocatechin-gallate (EGCG) solution on hepatic toxicity induced by gentamicin (G) administration in rats. Five groups were evaluated, a c…
View article: Evaluation of Oxidative Stress Biomarkers, Pro-Inflammatory Cytokines, and Histological Changes in Experimental Hypertension, Dyslipidemia, and Type 1 Diabetes Mellitus
Evaluation of Oxidative Stress Biomarkers, Pro-Inflammatory Cytokines, and Histological Changes in Experimental Hypertension, Dyslipidemia, and Type 1 Diabetes Mellitus Open
The present study aims to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors, namely, hypertension, dyslipidemia, and type 1 diabetes mellitus. Hyperte…
View article: Periodontitis in Ischemic Stroke Patients: Case Definition Challenges of the New Classification Scheme (2018)
Periodontitis in Ischemic Stroke Patients: Case Definition Challenges of the New Classification Scheme (2018) Open
The identification of the associative relationships between ischemic stroke (IS) and risk factors such as advanced age and periodontitis is essential to design real screening protocols and to address them using primary and secondary preven…
View article: Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation
Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation Open
We investigated the in vivo effect of curcumin nanoparticles (nC) in addition to diclofenac sodium on local edema and oxidative stress parameters in carrageenan-induced paw edema on rats. Seven groups were investigated: control group (C), …
View article: Cytotoxic Effects on Gingival Mesenchymal Stromal Cells and Root Surface Modifications Induced by Some Local Antimicrobial Products Used in Periodontitis Treatment
Cytotoxic Effects on Gingival Mesenchymal Stromal Cells and Root Surface Modifications Induced by Some Local Antimicrobial Products Used in Periodontitis Treatment Open
(1) Background: this study aims to test the cytotoxicity of three antimicrobial products used in periodontitis treatment on gingival mesenchymal stem cells (gMSCs) and their influence on root surfaces and gMSC adhesion. We tested the null …
View article: Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up
Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up Open
The long-term outcomes of "epi-off" accelerated corneal collagen crosslinking-UVA (9 mW/cm2 for 10 minutes) are similar to standard "epi-off" corneal collagen crosslinking procedure in the treatment of progressive keratoconus.
View article: Artificial Intelligence and Experimental Medical Research
Artificial Intelligence and Experimental Medical Research Open
Experimental medical research is under development and transformation due to convergence with various and extensive data resources. Meaningful research focused on one subject is a challenging task and is a time-consuming activity. Extensiv…
View article: Oral Mesenchymal Stromal Cells in Systemic Sclerosis: Characterization and Response to a Hyaluronic-Acid-Based Biomaterial
Oral Mesenchymal Stromal Cells in Systemic Sclerosis: Characterization and Response to a Hyaluronic-Acid-Based Biomaterial Open
Introduction. As oral mesenchymal stromal cells (MSCs) have not, to date, been isolated from systemic sclerosis (SSc) patients, the aim of this in vitro experiment was to characterize gingival MSCs (SScgMSCs) and granulation tissue MSCs (S…
View article: Multi-Organ Protective Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Rats with Type 1 Diabetes Mellitus
Multi-Organ Protective Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Rats with Type 1 Diabetes Mellitus Open
The objectives of this study were to investigate the cardio-protective, hepatoprotective and nephroprotective effects of curcumin nanoparticle (NC) pretreatment compared to conventional curcumin (CC) on acute myocardial infarction (AMI) in…
View article: Assessment of mismatch repair deficiency, CDX2, beta-catenin and E-cadherin expression in colon cancer: molecular characteristics and impact on prognosis and survival – an immunohistochemical study
Assessment of mismatch repair deficiency, CDX2, beta-catenin and E-cadherin expression in colon cancer: molecular characteristics and impact on prognosis and survival – an immunohistochemical study Open
Microsatellite instability (MSI) or the deficiency of mismatch repair (MMR) proteins is one of the molecular pathways of colorectal tumorigenesis and may have important clinical implications in predicting the treatment response. We evaluat…
View article: Rehabilitation challenges in COVID-19 induced acute polyradiculoneuropathies
Rehabilitation challenges in COVID-19 induced acute polyradiculoneuropathies Open
Introduction. SARS-COV 2 infection causes damage of the peripheral nervous system: loss of smell loss of taste and demyelination or axonal injury in the spinal roots and motor and sensory nerves with acute polyradiculoneuritis. As many peo…
View article: Neuroplasticity pathophysiological mechanisms underlying neuro-optometric rehabilitation in ischemic stroke – a brief review
Neuroplasticity pathophysiological mechanisms underlying neuro-optometric rehabilitation in ischemic stroke – a brief review Open
Neuroplasticity is an essential phenomenon underlying on neurorehabilitation process, by which the brain can remodel the dysfunction consequent to a lesion. Ischemic brain lesions are the most frequent brain lesions often associated with v…
View article: Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9, Histological Changes and Renal Function in Experimental Nephrotoxicity Induced by Gentamicin
Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9, Histological Changes and Renal Function in Experimental Nephrotoxicity Induced by Gentamicin Open
Background: Our study aimed to assess the efficiency of Curcumin nanoformulation (LCC) on experimental nephrotoxicity induced by Gentamicin in rats. Methods: Six groups of seven rats were used: C—(control group) received saline solution i.…
View article: <p>Refractive Lens Exchange in Hyperopic Presbyopes with the Acrysof IQ Panoptix Intraocular Lens: One-Year Results and Analysis of the Literature</p>
Refractive Lens Exchange in Hyperopic Presbyopes with the Acrysof IQ Panoptix Intraocular Lens: One-Year Results and Analysis of the Literature Open
The Acrysof Panoptix trifocal artificial lens offers a good vision at distance, intermediate and near, with a good quality of vision and refraction.
View article: Fractal Analysis of Retinal Vessels and their Relationship with Cerebral Microcirculation Pathology – A Narrative Review
Fractal Analysis of Retinal Vessels and their Relationship with Cerebral Microcirculation Pathology – A Narrative Review Open
One of the most reliable in vivo examination methods of human microvasculature is represented by ophthalmoscopy. Due to ophthalmoscopy, retinal circulation can reveal multiple morphological details that can serve as diagnosis biomarkers fo…