Adriana Moldovan
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View article: Identification and characterization of a ubiquitin E3 RING ligase of the Chlamydia-like bacterium Simkania negevensis
Identification and characterization of a ubiquitin E3 RING ligase of the Chlamydia-like bacterium Simkania negevensis Open
In the arms race between a pathogen and the host, the defense mechanisms of the host cell, including the ubiquitin system, are often counteracted by bacteria. Simkania negevensis (Sne), an obligate intracellular Chlamydia -like bacterium c…
View article: Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages
Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages Open
Staphylococcus aureus is a notorious human pathogen that thrives in macrophages. It resides in mature phagolysosomes, where a subset of the bacteria eventually begin to proliferate. How S. aureus acquires essential nutrients, such as amino…
View article: Dual Isotopologue Profiling of Bacterial Pathogens and their Host Cells: Metabolic Adaptation of Human Macrophages and Fallopian Tube Cells to Intracellular <i>Chlamydia trachomatis</i>
Dual Isotopologue Profiling of Bacterial Pathogens and their Host Cells: Metabolic Adaptation of Human Macrophages and Fallopian Tube Cells to Intracellular <i>Chlamydia trachomatis</i> Open
Chlamydia trachomatis is a Gram-negative bacterium that utilizes multiple host-derived substrates to ensure its intracellular survival. In this study, human fallopian tube (HFT) cells, and human macrophages polarized toward a pro-in…
View article: A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus Open
Staphylococcus aureus is an opportunistic pathogen causing severe diseases. Recently, S. aureus was recognized as intracellular pathogen, whereby the intracellular niche promotes immune evasion and antibiotic resistance. Interaction of S. …
View article: The AusAB non-ribosomal peptide synthetase of <i>Staphylococcus aureus</i> preferentially generates phevalin in host-mimicking media
The AusAB non-ribosomal peptide synthetase of <i>Staphylococcus aureus</i> preferentially generates phevalin in host-mimicking media Open
Non-ribosomal peptide synthetases (NRPSs) are modular multidomain enzymes responsible for the biosynthesis of various secondary metabolites in an mRNA template-independent manner. They are predominantly present in bacteria and fungi, where…
View article: <i>Chlamydia trachomatis</i> exploits sphingolipid metabolic pathways during infection of phagocytes
<i>Chlamydia trachomatis</i> exploits sphingolipid metabolic pathways during infection of phagocytes Open
Chlamydiae are obligate intracellular pathogens that utilize host cell metabolites for catabolic and anabolic processes. The bacteria replicate in epithelial cells from which they take up sphingolipids (SL) and incorporate them into the ch…
View article: A Multicellular In Vitro Model of the Human Intestine with Immunocompetent Features Highlights Host‐Pathogen Interactions During Early <i>Salmonella</i> Typhimurium Infection
A Multicellular In Vitro Model of the Human Intestine with Immunocompetent Features Highlights Host‐Pathogen Interactions During Early <i>Salmonella</i> Typhimurium Infection Open
Studying the molecular basis of intestinal infections caused by enteric pathogens at the tissue level is challenging, because most human intestinal infection models have limitations, and results obtained from animals may not reflect the hu…
View article: A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus Open
Staphylococcus aureus is an opportunistic pathogen causing severe diseases. Recently, S. aureus was recognized as intracellular pathogen with the intracellular niche promoting immune evasion and antibiotic resistance. We identified an alte…
View article: A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus Open
Staphylococcus aureus is an opportunistic pathogen causing severe diseases. Recently, S. aureus was recognized as intracellular pathogen, whereby the intracellular niche promotes immune evasion and antibiotic resistance. Interaction of S. …
View article: Author response: A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
Author response: A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus Open
View article: Identification and characterization of a ubiquitin E3 RING ligase of the<i>Chlamydia</i>-like bacterium<i>Simkania negevensis</i>
Identification and characterization of a ubiquitin E3 RING ligase of the<i>Chlamydia</i>-like bacterium<i>Simkania negevensis</i> Open
In the arms race between a pathogen and the host, many bacteria have acquired a sizable armory to counteract or change the defense mechanisms of the host cell, including the eukaryotic ubiquitin system. Simkania negevensis , an obligate in…
View article: The AusAB non-ribosomal peptide synthase in<i>Staphylococcus aureus</i>preferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products
The AusAB non-ribosomal peptide synthase in<i>Staphylococcus aureus</i>preferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products Open
Non-ribosomal peptide synthases (NRPS) are modular multidomain enzymes, responsible for the biosynthesis of various secondary metabolites, in a mRNA-template independent manner. They are predominantly present in bacteria and fungi, where t…
View article: A Photoconvertible Reporter System for Bacterial Metabolic Activity Reveals That Staphylococcus aureus Enters a Dormant-Like State to Persist within Macrophages
A Photoconvertible Reporter System for Bacterial Metabolic Activity Reveals That Staphylococcus aureus Enters a Dormant-Like State to Persist within Macrophages Open
The capacity of Staphylococcus aureus to survive and persist within phagocytic cells has been associated with antibiotic treatment failure and recurrent infections. Here, we investigated the molecular mechanisms leading to S. aureus persis…
View article: Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells
Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells Open
Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Uptake by host cells is thought to contribute to pathogenicity and persistence of the bacterium. Upon internaliz…
View article: The Expandables: Cracking the Staphylococcal Cell Wall for Expansion Microscopy
The Expandables: Cracking the Staphylococcal Cell Wall for Expansion Microscopy Open
Expansion Microscopy (ExM) is a novel tool improving the resolution of fluorescence microscopy by linking the sample into a hydrogel that gets physically expanded in water. Previously, we have used ExM to visualize the intracellular Gram-n…
View article: Intracellular<i>Staphylococcus aureus</i>employs the cysteine protease staphopain A to induce host cell death in epithelial cells
Intracellular<i>Staphylococcus aureus</i>employs the cysteine protease staphopain A to induce host cell death in epithelial cells Open
Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Intracellularity is thought to contribute to pathogenicity and persistence of the bacterium. Upon internalizatio…
View article: In or out: Phagosomal escape of<i>Staphylococcus aureus</i>
In or out: Phagosomal escape of<i>Staphylococcus aureus</i> Open
Staphylococcus aureus is internalised by host cells in vivo, and recent research results suggest that the bacteria use this intracellularity to persist in the host and form a reservoir for recurrent infections. However, in different cells …
View article: HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens
HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens Open
Phenotypic heterogeneity in microbial communities enables genetically identical organisms to behave differently even under the same environmental conditions. Photorhabdus luminescens, a bioluminescent Gram-negative bacterium, contains a co…