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View article: <b>Cerebrospinal fluid fatty acids, hypothalamic inflammation, and weight loss in human obesity: a longitudinal study.</b>
<b>Cerebrospinal fluid fatty acids, hypothalamic inflammation, and weight loss in human obesity: a longitudinal study.</b> Open
Preclinical studies show that dietary or central administration of monounsaturated (MUFAs) and polyunsaturated fatty acids (PUFAs) can reduce food intake, enhance energy expenditure and attenuate hypothalamic inflammation (HI), whereas sat…
View article: Diffusivity alterations related to cognitive performance and phenylalanine levels in early-treated adults with phenylketonuria
Diffusivity alterations related to cognitive performance and phenylalanine levels in early-treated adults with phenylketonuria Open
Background Altered white matter (WM) is consistently reported in patients with phenylketonuria (PKU). However, the knowledge about WM microstructural integrity in early-treated adults with classical PKU and its relationship with cognition …
View article: Preeclampsia as an independent predictor of atherosclerosis progression in women with type 1 diabetes: a 5-year prospective study
Preeclampsia as an independent predictor of atherosclerosis progression in women with type 1 diabetes: a 5-year prospective study Open
View article: Machine learning allows robust classification of visceral fat in women with obesity using common laboratory metrics
Machine learning allows robust classification of visceral fat in women with obesity using common laboratory metrics Open
The excessive accumulation and malfunctioning of visceral adipose tissue (VAT) is a major determinant of increased risk of obesity-related comorbidities. Thus, risk stratification of people living with obesity according to their amount of …
View article: Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels
Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels Open
View article: <b>Hypothalamic inflammation improves through bariatric surgery and hypothalamic volume predicts short-term weight loss response in adults with or without type 2 diabetes.</b>
<b>Hypothalamic inflammation improves through bariatric surgery and hypothalamic volume predicts short-term weight loss response in adults with or without type 2 diabetes.</b> Open
OBJECTIVE: Preclinical research implicates hypothalamic inflammation (HI) in obesity and type 2 diabetes pathophysiology. However, their pathophysiological relevance and potential reversibility need to be better defined. We sought t…
View article: <b>Hypothalamic inflammation improves through bariatric surgery and hypothalamic volume predicts short-term weight loss response in adults with or without type 2 diabetes.</b>
<b>Hypothalamic inflammation improves through bariatric surgery and hypothalamic volume predicts short-term weight loss response in adults with or without type 2 diabetes.</b> Open
OBJECTIVE: Preclinical research implicates hypothalamic inflammation (HI) in obesity and type 2 diabetes pathophysiology. However, their pathophysiological relevance and potential reversibility need to be better defined. We sought t…
View article: Preparing Enteral Formulas for Adult Patients with Phenylketonuria: A Minor Necessity but Major Challenge—A Case Report
Preparing Enteral Formulas for Adult Patients with Phenylketonuria: A Minor Necessity but Major Challenge—A Case Report Open
Phenylketonuria (PKU) is the most frequent of the congenital errors of amino acid (AA) metabolism worldwide. It leads to the accumulation of the essential AA phenylalanine (Phe) and it is associated with severe neurological defects. The ea…
View article: Lysinuric Protein Intolerance and Its Nutritional and Multisystemic Challenges in Pregnancy: A Case Report and Literature Review
Lysinuric Protein Intolerance and Its Nutritional and Multisystemic Challenges in Pregnancy: A Case Report and Literature Review Open
Lysinuric protein intolerance (LPI) is a rare inborn error of metabolism (IEM), classified as an inherited aminoaciduria, caused by mutations in the SLC7A7 gene, leading to a defective cationic amino acid transport. The metabolic adaptatio…
View article: Bariatric Surgery Outcomes in Patients with Chronic Kidney Disease
Bariatric Surgery Outcomes in Patients with Chronic Kidney Disease Open
Obesity increases the risk of developing chronic kidney disease (CKD), which has a major negative impact on global health. Bariatric surgery (BS) has demonstrated a substantial improvement of obesity-related comorbidities and thus, it has …
View article: Nuclear Magnetic Resonance-Based Lipidomics in the Assessment of Cardiometabolic Risk in Type 1 Diabetes: An Exploratory Analysis
Nuclear Magnetic Resonance-Based Lipidomics in the Assessment of Cardiometabolic Risk in Type 1 Diabetes: An Exploratory Analysis Open
In our preliminary study of individuals with T1D at high risk, several 1H NMR-derived lipidomic parameters were independently associated with preclinical atherosclerosis. Specifically, ω-6 fatty acids and linoleic acid seem prom…
View article: Bariatric Surgery Outcomes in Patients with Kidney Transplantation
Bariatric Surgery Outcomes in Patients with Kidney Transplantation Open
Obesity and kidney transplantation (KTx) are closely related. Obesity increases the risk of chronic kidney disease and can be a relative contraindication for KTx. Besides, KTx recipients are predisposed to obesity and its comorbidities. Co…
View article: The Steno Type 1 Risk Engine identifies preclinical atherosclerosis better than the ESC/EASD-2019 Guidelines in adult subjects with type 1 diabetes at high-risk
The Steno Type 1 Risk Engine identifies preclinical atherosclerosis better than the ESC/EASD-2019 Guidelines in adult subjects with type 1 diabetes at high-risk Open
Objective: To evaluate the concordance between the ESC/EASD-2019 and the Steno Type 1 Risk Engine (Steno-Risk) cardiovascular risk scales in persons with type 1 diabetes (T1D) without cardiovascular disease (CVD), and to analyze their re…
View article: The Steno Type 1 Risk Engine identifies preclinical atherosclerosis better than the ESC/EASD-2019 Guidelines in adult subjects with type 1 diabetes at high-risk
The Steno Type 1 Risk Engine identifies preclinical atherosclerosis better than the ESC/EASD-2019 Guidelines in adult subjects with type 1 diabetes at high-risk Open
Objective: To evaluate the concordance between the ESC/EASD-2019 and the Steno Type 1 Risk Engine (Steno-Risk) cardiovascular risk scales in persons with type 1 diabetes (T1D) without cardiovascular disease (CVD), and to analyze their re…
View article: The Steno Type 1 Risk Engine identifies preclinical atherosclerosis better than the ESC/EASD-2019 Guidelines in adult subjects with type 1 diabetes at high-risk
The Steno Type 1 Risk Engine identifies preclinical atherosclerosis better than the ESC/EASD-2019 Guidelines in adult subjects with type 1 diabetes at high-risk Open
Objective: To evaluate the concordance between the ESC/EASD-2019 and the Steno Type 1 Risk Engine (Steno-Risk) cardiovascular risk scales in persons with type 1 diabetes (T1D) without cardiovascular disease (CVD), and to analyze their re…
View article: Use of the Steno T1 Risk Engine Identifies Preclinical Atherosclerosis Better Than Use of ESC/EASD-2019 in Adult Subjects With Type 1 Diabetes at High Risk
Use of the Steno T1 Risk Engine Identifies Preclinical Atherosclerosis Better Than Use of ESC/EASD-2019 in Adult Subjects With Type 1 Diabetes at High Risk Open
OBJECTIVE To evaluate the concordance between the 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD (ESC/EASD-2019) and the Steno T1 Risk Engine (Steno-Risk) cardiovascular …
View article: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders Open
View article: Carotid Ultrasonography as a Strategy to Optimize the Management of Cardiovascular Risk in Patients with Type 1 Diabetes: A Cohort Study
Carotid Ultrasonography as a Strategy to Optimize the Management of Cardiovascular Risk in Patients with Type 1 Diabetes: A Cohort Study Open
Background : Although cardiovascular disease (CVD) remains the leading cause of mortality in type 1 diabetes (T1D), the use of cardioprotective drugs is scarce. We aimed to evaluate the impact of carotid ultrasonography (US) on the improve…
View article: Blood glucose level after infusing an activated charcoal suspension for acute drug poisoning.
Blood glucose level after infusing an activated charcoal suspension for acute drug poisoning. Open
Activated charcoal induces an increase in blood glucose level that is statistically but not clinically significant. The increase is comparable to the increase after breakfast.
View article: OR03-05 Novel Lipidome Signature in Active Cushing Syndrome Revealed by UHPLC-MS Metabolomics
OR03-05 Novel Lipidome Signature in Active Cushing Syndrome Revealed by UHPLC-MS Metabolomics Open
Background: Alterations in circulating amino acids, polyamines and acylcarnitines have been reported in patients with endogenous chronic hypercortisolism. However, lipid metabolites profiling and its interplay with the serum metabolome and…
View article: Outcomes of pancreas transplantation in older diabetic patients
Outcomes of pancreas transplantation in older diabetic patients Open
Objective Improvement in insulin alternatives is leading to a delayed presentation of microvascular and macrovascular complications of diabetes. The objective of this study was to evaluate the long-term outcomes of older (≥50 years) diabet…
View article: Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly Open
Background: Mid-life obesity is related to increased risk for overall dementia and Alzheimer´s disease (AD) dementia. In the present work, we aimed to investigate the impact of obesity on brain structure, metabolism, and cerebrospinal flui…
View article: Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly Open
In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
View article: Preeclampsia Is Associated With Increased Preclinical Carotid Atherosclerosis in Women With Type 1 Diabetes
Preeclampsia Is Associated With Increased Preclinical Carotid Atherosclerosis in Women With Type 1 Diabetes Open
Purpose Although preeclampsia (PE) is a well-established cardiovascular risk factor (CVRF) in the general population, its role in type 1 diabetes (T1D) has been scarcely studied. We assessed the association between PE and preclinical ather…
View article: P2‐347: OVERLAP PATTERN OF HYPERMETABOLISM AND BRAIN ATROPHY RELATED WITH OBESITY IN HEALTHY ELDERLY
P2‐347: OVERLAP PATTERN OF HYPERMETABOLISM AND BRAIN ATROPHY RELATED WITH OBESITY IN HEALTHY ELDERLY Open
Mid-life obesity is a well-established risk factor for Alzheimer's Disease (AD). However the impact of late-life obesity on brain structure and metabolism and whether it has a differential effect in males and females is under debate. There…
View article: Obesity and Alzheimer's disease, does the obesity paradox really exist? A magnetic resonance imaging study
Obesity and Alzheimer's disease, does the obesity paradox really exist? A magnetic resonance imaging study Open
Mid-life obesity is an established risk factor for Alzheimer's disease (AD) dementia,whereas late-life obesity has been proposed as a protective state. Weight loss, whichpredates cognitive decline, might explain this obesity paradox on AD …
View article: Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer's disease
Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer's disease Open
Weight loss has been proposed as a sign of pre-clinical Alzheimer Disease (AD). To test this hypothesis, we have evaluated the association between longitudinal changes in weight trajectories, cognitive performance, AD biomarker profiles an…
View article: Clinical onset of celiac disease after duodenal switch: a case report
Clinical onset of celiac disease after duodenal switch: a case report Open