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View article: Multiple Myeloma Laboratory Diagnostics Made Simple: Practical Insights and Key Recommendations
Multiple Myeloma Laboratory Diagnostics Made Simple: Practical Insights and Key Recommendations Open
Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease…
View article: Diagnóstico e Seguimento Laboratorial de Doentes com Mieloma Múltiplo: Recomendações do Grupo Português do Mieloma Múltiplo
Diagnóstico e Seguimento Laboratorial de Doentes com Mieloma Múltiplo: Recomendações do Grupo Português do Mieloma Múltiplo Open
O mieloma múltiplo é uma neoplasia de plasmócitos que, na maioria dos casos, se associa à secreção de imunoglobulinas monoclonais e que pode cursar com um atingimento multiorgânico. O diagnóstico atempado do mieloma múltiplo é essencial pa…
View article: Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)
Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS) Open
Bone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adi…
View article: 781 | IMPACT OF OBESITY AND OVERWEIGHT ON OUTCOMES OF PATIENTS WITH B‐CELL LYMPHOMAS AND MULTIPLE MYELOMA TREATED WITH CAR‐T CELLS: A SYSTEMATIC REVIEW AND META‐ANALYSIS
781 | IMPACT OF OBESITY AND OVERWEIGHT ON OUTCOMES OF PATIENTS WITH B‐CELL LYMPHOMAS AND MULTIPLE MYELOMA TREATED WITH CAR‐T CELLS: A SYSTEMATIC REVIEW AND META‐ANALYSIS Open
View article: Growth factor concentration in canine platelet-rich plasma and platelet lysate is correlated with platelet number
Growth factor concentration in canine platelet-rich plasma and platelet lysate is correlated with platelet number Open
Platelet lysate (PL) and platelet-rich plasma (PRP) are blood derivatives that have gained increasing clinical relevance in both human and veterinary medicine in recent years. These derivatives exhibit anti-inflammatory and regenerative po…
View article: Practical management of disease-related manifestations and drug toxicities in patients with multiple myeloma
Practical management of disease-related manifestations and drug toxicities in patients with multiple myeloma Open
Multiple myeloma (MM) is a very heterogeneous disease with multiple symptoms and clinical manifestations. MM affects mainly elderly patients and is difficult to manage in the presence of comorbidities, polypharmacy, frailty and adverse eve…
View article: A rare cause of Acquired Hemolytic Anemia in a child; Donath-Landsteiner antibody
A rare cause of Acquired Hemolytic Anemia in a child; Donath-Landsteiner antibody Open
Introduction/Objective INTRODUCTION: The Donath-Landsteiner (DL) antibody is known to cause paroxysmal cold hemoglobinuria (PCH), a rare form of intravascular hemolytic anemia which is precipitated by an IgG biphasic hemolysin with specifi…
View article: PB2153: IMPACT OF EXTRAMEDULLARY DISEASE IN PATIENTS WITH MULTIPLE MYELOMA: MULTICENTER RETROSPECTIVE ANALYSIS
PB2153: IMPACT OF EXTRAMEDULLARY DISEASE IN PATIENTS WITH MULTIPLE MYELOMA: MULTICENTER RETROSPECTIVE ANALYSIS Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Extramedullary disease (EMD) is a rare form of multiple myeloma (MM), with an incidence that ranges from 0.5-4.8% in patients (pts) with newly diagnosed MM and 3.4…
View article: PB1867: ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 – REAL-LIFE EXPERIENCE IN THE REDEFINITION OF EUROPEAN LEUKEMIANET RISK CLASSIFICATION
PB1867: ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 – REAL-LIFE EXPERIENCE IN THE REDEFINITION OF EUROPEAN LEUKEMIANET RISK CLASSIFICATION Open
Topic: 4. Acute myeloid leukemia - Clinical Background: Acute myeloid leukemia (AML) with mutated Nucleophosmin-1 (NPM1) usually carries a better prognosis, being associated with favorable response to standard intensive chemotherapy (IC). …
View article: PB1880: ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 – A DIFFERENT ENTITY IN THE ELDERLY?
PB1880: ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 – A DIFFERENT ENTITY IN THE ELDERLY? Open
Topic: 4. Acute myeloid leukemia - Clinical Background: Acute myeloid leukemia (AML) with mutated Nucleophosmin-1 (NPM1MT) occurs in approximately 30% of patients (pts) with AML and usually carries a better prognosis. However, the positive…
View article: Recomendações do Grupo Português do Mieloma Múltiplo para Tratamento do Mieloma Múltiplo
Recomendações do Grupo Português do Mieloma Múltiplo para Tratamento do Mieloma Múltiplo Open
O tratamento do mieloma múltiplo tem sido amplamente alterado com introdução de várias terapêuticas inovadoras. A otimização da sequenciação terapêutica através do uso combinado dos vários fármacos desenvolvidos nos últimos anos e a atençã…
View article: P014: Prognostic significance of nutritional indexes (CONUT and PNI) in classical Hodgkin lymphoma patients
P014: Prognostic significance of nutritional indexes (CONUT and PNI) in classical Hodgkin lymphoma patients Open
Figure 1: ROC curve for PNI in predicting progression-free survival and Overall and progression-free survival according to PNI and CONUT scores. Background: Several recent studies have shown the clinical significance of poor nutritional st…
View article: P011: IPS-7 or IPS-3 to identify very-high risk patients in advanced Classical Hodgkin’s Lymphoma: Which score to choose
P011: IPS-7 or IPS-3 to identify very-high risk patients in advanced Classical Hodgkin’s Lymphoma: Which score to choose Open
Figure 1: PFS and OS for both IPS-3 and IPS-7 scores Introduction: The survival of patients (pts) with classic Hodgkin Lymphoma (cHL) has been significantly increased due to refinement of therapeutic strategies. International Prognostic Sc…
View article: P1358: WILL COVID-19 PANDEMIC CHANGE MOBILIZATION STRATEGY OF HEMATOPOIETIC STEM CELLS IN MULTIPLE MYELOMA PATIENTS FOR THE BETTER?
P1358: WILL COVID-19 PANDEMIC CHANGE MOBILIZATION STRATEGY OF HEMATOPOIETIC STEM CELLS IN MULTIPLE MYELOMA PATIENTS FOR THE BETTER? Open
Background: Autologous hematopoietic stem cell transplantation (ASCT) is the current standard of care for younger patients (pts) with multiple myeloma (MM), improving overall survival (OS) and progression free survival (PFS). According to …
View article: PB2069: A CASE OF HAIRY CELL LEUKEMIA PRESENTED AS HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
PB2069: A CASE OF HAIRY CELL LEUKEMIA PRESENTED AS HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Open
Background: Hairy cell leukemia (HCL) is an indolent and uncommon chronic B cell lymphoproliferative disorder. The clinical picture is mainly dominated by cytopenias and splenomegaly, with some patients only receiving a watch and wait appr…
View article: Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature
Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature Open
Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug c…
View article: NEUTROPHIL/LYMPHOCYTE RATIO AND MONOCYTE/LYMPHOCYTE RATIO – PROMISING PROGNOSTIC BIOMARKERS IN DIFFUSE LARGE B‐CELL LYMPHOMA?
NEUTROPHIL/LYMPHOCYTE RATIO AND MONOCYTE/LYMPHOCYTE RATIO – PROMISING PROGNOSTIC BIOMARKERS IN DIFFUSE LARGE B‐CELL LYMPHOMA? Open
Background: During the past few years, several studies have tried to identify biomarkers that could improve the current prognostic assessment in diffuse large B-cell lymphoma (DLBCL). Neutrophil/Lymphocyte Ratio (NLR) and Monocyte/ Lymphoc…
View article: DIFFUSE LARGE B‐CELL LYMPHOMA IN ELDERLY PATIENTS: OUTCOME IN REAL‐WORLD CLINICAL PRACTICE
DIFFUSE LARGE B‐CELL LYMPHOMA IN ELDERLY PATIENTS: OUTCOME IN REAL‐WORLD CLINICAL PRACTICE Open
Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and is more frequent in elderly patients (pts), which have a worse prognosis than younger patients. This is partially explained by the exi…
View article: SURVIVAL INDEPENDENT PREDICTIVE VALUE OF INTERIM FDG<sup>18</sup>‐PET IN NEWLY DIAGNOSED DIFFUSE LARGE B CELL LYMPHOMA
SURVIVAL INDEPENDENT PREDICTIVE VALUE OF INTERIM FDG<sup>18</sup>‐PET IN NEWLY DIAGNOSED DIFFUSE LARGE B CELL LYMPHOMA Open
Introduction: Interim response evaluation by PET (iPET) in diffuse large B cell lymphoma (DLBCL) is encouraged to rule out disease progression and has been suggested to be predictive of survival. However, treatment guidance by iPET is not …
View article: The complete mitogenome of the invasive Japanese mud snail <i>Batillaria attramentaria</i> (Gastropoda: Batillariidae) from Elkhorn Slough, California, USA
The complete mitogenome of the invasive Japanese mud snail <i>Batillaria attramentaria</i> (Gastropoda: Batillariidae) from Elkhorn Slough, California, USA Open
Genomic analysis of the invasive marine snail Batillaria attramentaria from Elkhorn Slough, Moss Landing, California, USA using 150 bp paired-end Illumina sequences resulted in the assembly of its complete mitogenome. The mitogenome…
View article: PS1413 INCIDENCE OF NEGATIVE MINIMAL RESIDUAL DISEASE IN MULTIPLE MYELOMA PATIENTS AFTER AUTOLOGOUS STEM CELL TRANSPLANT
PS1413 INCIDENCE OF NEGATIVE MINIMAL RESIDUAL DISEASE IN MULTIPLE MYELOMA PATIENTS AFTER AUTOLOGOUS STEM CELL TRANSPLANT Open
Background: The survival of multiple myeloma (MM) patients (pts) has improved significantly over the last decade. However, MM remains an incurable disease. Minimal residual disease (MRD) is considered a crucial prognostic factor. Previous …
View article: PF763 STEM CELL TRANSPLANTATION FOR MANTLE‐CELL LYMPHOMA ‐ A SINGLE CENTRE EXPERIENCE (2010–2018)
PF763 STEM CELL TRANSPLANTATION FOR MANTLE‐CELL LYMPHOMA ‐ A SINGLE CENTRE EXPERIENCE (2010–2018) Open
Background: Mantle cell lymphoma (MCL) is a rare subtype of non‐Hodgkin lymphoma. The standard of care for MCL, include regimens containing cytarabine, followed by consolidation with autologous stem cell transplantation (auto‐HSCT) and mai…
View article: PB2348 IMMUNE RECONSTITUION OF ΓΔT CELLS AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA – IMPACT OF REFRACTORINESS/RELAPSE AND PREVIOUS THERAPEUTICS ON RECOVERY
PB2348 IMMUNE RECONSTITUION OF ΓΔT CELLS AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA – IMPACT OF REFRACTORINESS/RELAPSE AND PREVIOUS THERAPEUTICS ON RECOVERY Open
Background: γδT cells are a minor circulant effector/cytotoxic population involved in immune surveillance, with evidence supporting their anti‐multiple myeloma (MM) role. Although lymphocyte recover after autologous hematopoietic stem cell…
View article: PB2358 THE IMPACT OF THE NUMBER OF CD34 + CELLS TRANSPLANTED IN ENGRAFTMENT AFTER AUTOLOGOUS TRANSPLANTATION OF HEMATOPOIETIC PROGENITORS
PB2358 THE IMPACT OF THE NUMBER OF CD34 + CELLS TRANSPLANTED IN ENGRAFTMENT AFTER AUTOLOGOUS TRANSPLANTATION OF HEMATOPOIETIC PROGENITORS Open
Background: Despite the emergence of new therapeutic options, autologous hematopoietic stem‐cell transplantation (AHCT) is still one of the pillars in the treatment of patients with multiple myeloma (MM), especially in younger and fit pati…
View article: Issue Information
Issue Information Open
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View article: Quantification and phenotypic characterization of peripheral blood Vδ1 + T cells in chronic lymphocytic leukemia and monoclonal B cell lymphocytosis
Quantification and phenotypic characterization of peripheral blood Vδ1 + T cells in chronic lymphocytic leukemia and monoclonal B cell lymphocytosis Open
Background Vδ1 + T cells, a subset of γδ T cells, are responsible for innate‐like immune responses. Recently, an anti‐tumor function mediated by MHC‐unrestricted recognition of lipid and stress molecules, has also been described in these c…
View article: Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic Implications
Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic Implications Open