Explanipedia

High-resolution multiplexed antibody-omics and interpretable machine learning unveil novel pathogenic mechanisms in kidney transplant rejection Open

Trirupa Chakraborty, Divya Bhakta, Anushka Saha, Camila Macedo, Daqiang Zhao , et al. · 2025

Antibody-mediated rejection (AbMR), driven by donor-specific alloantibodies (DSAs), is a major cause of late-stage kidney allograft failure, leading to premature graft loss in over half of affected patients. Despite efforts to link DSA fea…

Donor-recipient mismatch at the <i>SIRPA</i> locus adversely affects kidney allograft outcomes Open

Daqiang Zhao, Hehua Dai, Camila Macedo, Steven M. Sanders, Charbel Elias , et al. · 2025

Donor-recipient mismatches in histocompatibility antigens recognized by lymphoid cells have been demonstrated to adversely affect allograft outcomes. In contrast, it remains unclear whether mismatches sensed by innate myeloid cells have a …

Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts Open

Zeynep Demir, Marc Raynaud, Gillian Divard, Kévin Louis, Agathe Truchot , et al. · 2025

Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health Open

Christopher Bellamy, Jacqueline G. O’Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal , et al. · 2024

The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evalua…

Enhanced Donor Antigen Presentation by B Cells Predicts Acute Cellular Rejection and Late Outcomes After Transplantation Open

Chethan Ashokkumar, Mylarappa Ningappa, Vikram Raghu, George Mazariegos, Brandon W. Higgs , et al. · 2024

Background. Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index…

Single center study investigating the clinical association of donor-derived cell-free DNA with acute outcomes in lung transplantation Open

Kentaro Noda, Mark E. Snyder, Qingyong Xu, David G. Peters, John F. McDyer , et al. · 2024

Background Circulating donor-derived cell-free DNA (dd-cfDNA) levels have been proposed as a potential tool for the diagnosis of graft injury. In this study, we prospectively investigated dd-cfDNA plasma levels and their association with s…

Reduction of HLA donor specific antibodies in heart transplant patients treated with proteasome inhibitors for antibody mediated rejection Open

Edward Horn, Qingyong Xu, Julie N. DiBridge, Jessica Huston, Gavin Hickey , et al. · 2023

In this project, we describe proteasome inhibitor (PI) treatment of antibody‐mediated rejection (AMR) in heart transplantation (HTX). From January 2018 to September 2021, 10 patients were treated with PI for AMR: carfilzomib (CFZ) n = 8; b…

O16 Toward a combined DR+DQ HLA molecular mismatch score for risk stratification of pediatric heart transplant patients Open

Massimo Mangiola, Marilyn Marrari, Carol Bentlejewski, Qingyong Xu, Adriana Zeevi , et al. · 2023

Impact of donor-specific anti-HLA antibody on cardiac hemodynamics and graft function 3 years after pediatric heart transplantation: First results from the CTOTC-09 multi-institutional study Open

Steven A. Webber, Hyunsook Chin, James D. Wilkinson, Brian Armstrong, Charles E. Canter , et al. · 2023

What is a clinically significant donor-specific antibody before lung transplantation? Open

Ramsey R. Hachem, Adriana Zeevi · 2023

Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56dimCD16bright natural killer cells during kidney allograft antibody–mediated rejection showing a new link between adaptive and innate humoral allo-immunity Open

É. Bailly, Camila Macedo, Jason Ossart, Kévin Louis, Xinyan Gu , et al. · 2023

Morphologic and immunophenotypic evaluation of liver allograft biopsies with contemporaneous serum DSA measurements Open

Mohamed El Hag, Hugo Kaneku, Dana Jorgensen, Adriana Zeevi, Heather L. Stevenson , et al. · 2023

Background Acute antibody mediated rejection is increasingly identified in liver allografts as a unique form of alloimmune injury associated with donor specific antibodies (DSA). This manifests pathologically as microvascular injury and C4…

Immunologic risk stratification of pediatric heart transplant patients by combining HLA-EMMA and PIRCHE-II Open

Mitchell A. Ellison, Massimo Mangiola, Marilyn Marrari, Carol Bentlejewski, J. Sadowski , et al. · 2023

Human leukocyte antigen (HLA) molecular mismatch is a powerful biomarker of rejection. Few studies have explored its use in assessing rejection risk in heart transplant recipients. We tested the hypothesis that a combination of HLA Epitope…

The evolving use of biomarkers in heart transplantation: Consensus of an expert panel Open

Jon Kobashigawa, Shelley Hall, Palak Shah, Barry Fine, Philip F. Halloran , et al. · 2023

Banff 2022 Liver Group Meeting Report: Monitoring Long Term Allograft Health Open

Christopher Bellamy, Jacqueline G. O’Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal , et al. · 2023

Virtual crossmatch for deceased donor kidney transplantation in the United States: A survey of histocompatibility lab directors and transplant surgeons Open

Chethan Puttarajappa, Amit D. Tevar, William Hoffman, Howard Degenholtz, Carrie A. Schinstock , et al. · 2022

Enhanced donor antigen presentation by B-cells predicts acute cellular rejection and late outcomes after transplantation Open

Chethan Ashokkumar, Mylarappa Ningappa, Vikram Raghu, George Mazariegos, Brandon W. Higgs , et al. · 2022

Purpose Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index (AP…

The Role of Dynamic DNA Methylation in Liver Transplant Rejection in Children Open

Mylarappa Ningappa, Xiaojian Shao, Chethan Ashokkumar, Qingyong Xu, Adriana Zeevi , et al. · 2022

Background. Transcriptional regulation of liver transplant (LT) rejection may reveal novel predictive and therapeutic targets. The purpose of this article is to test the role of differential DNA methylation in children with biopsy-proven a…

Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal Open

Fiorella Calabrese, Anja C. Roden, Elizabeth N. Pavlisko, Francesca Lunardi, Desley Neil , et al. · 2022

The role of dynamic DNA methylation in liver transplant rejection in children Open

Mylarappa Ningappa, Xiaojian Shao, Chethan Ashokkumar, Qingyong Xu, Adriana Zeevi , et al. · 2022

Background Transcriptional regulation of liver transplant (LT) rejection may reveal novel predictive and therapeutic targets. Purpose To test the role of differential DNA methylation in children with biopsy-proven acute cellular rejection …

The Clinical Impact of Anti-HLA Donor Specific Antibody Detection Through First Year Screening on Stable Kidney Transplant Recipients Open

Akhil Sharma, Dana Jorgensen, Rajil Mehta, Puneet Sood, Chethan Puttarajappa , et al. · 2022

Graphical Abstract

Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation Open

Kévin Louis, Paul Fadakar, Camila Macedo, Masaki Yamada, Michelle Lucas , et al. · 2022

Positive flow cytometry crossmatch with discrepant antibody testing results following COVID-19 vaccination Open

Qingyong Xu, Puneet Sood, Dennis Helmick, Jon Lomago, Amit D. Tevar , et al. · 2021

Approaching the sensitized lung patient: risk assessment for donor acceptance Open

Massimo Mangiola, Marilyn Marrari, Qingyong Xu, Pablo G. Sánchez, Adriana Zeevi · 2021

The presence of HLA antibodies is widely recognized as a barrier to solid organ transplantation, and for lung transplant candidates, it has a significant negative impact on both waiting time and waiting list mortality. Although HLA antibod…

T-bet+CD27+CD21– B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants Open

Kévin Louis, É. Bailly, Camila Macedo, Louis Lau, Bala Ramaswami , et al. · 2021

Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell responses and the molecular components control…

Trends and impact on cold ischemia time and clinical outcomes using virtual crossmatch for deceased donor kidney transplantation in the United States Open

Chethan Puttarajappa, Dana Jorgensen, Jonathan G. Yabes, Kwonho Jeong, Adriana Zeevi , et al. · 2021

HLA Eplet Mismatch Analysis of a Large Multi-Center Pediatric Heart Transplant Cohort: Not All Transplants are Immunologically Equal Open

Massimo Mangiola, Marilyn Marrari, Carol Bentlejewski, J. Sadowskij, Dwayne Zern , et al. · 2021

Early Phase Circulating Donor-Derived Cell-Free DNA in Patients after Lung Transplantation Open

Kentaro Noda, Barbara J. Philips, N. Ryssel, Qingyong Xu, Takashi Harano , et al. · 2021

Donor-derived regulatory dendritic cell infusion results in host cell cross-dressing and T cell subset changes in prospective living donor liver transplant recipients Open

Camila Macedo, Lillian Tran, Alan F. Zahorchak, Helong Dai, Xinyan Gu , et al. · 2020

Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejection in Kidney Transplantation Open

Kévin Louis, Camila Macedo, É. Bailly, Louis Lau, Bala Ramaswami , et al. · 2020

Significance Statement Most studies investigating the mechanisms of antibody-mediated rejection, a major cause of kidney allograft failure, have focused on characterizing the role of donor-specific antibodies (DSAs), whereas the alloreacti…

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