Adrianne L. Stefanski YOU? Author Swipe

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An open source knowledge graph ecosystem for the life sciences Open

Tiffany J Callahan, Ignacio J. Tripodi, Adrianne L. Stefanski, Luca Cappelletti, Sanya B. Taneja , et al. · 2024

An Open-Source Knowledge Graph Ecosystem for the Life Sciences Open

Tiffany J Callahan, Ignacio J. Tripodi, Adrianne L. Stefanski, Luca Cappelletti, Sanya B. Taneja , et al. · 2023

Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but researchers face significant integration challen…

Ontologizing health systems data at scale: making translational discovery a reality Open

Tiffany J Callahan, Adrianne L. Stefanski, Jordan M Wyrwa, Chenjie Zeng, Anna Ostropolets , et al. · 2023

Ontologizing Health Systems Data at Scale: Making Translational Discovery a Reality Open

Tiffany J Callahan, Adrianne L. Stefanski, Jordan M Wyrwa, Chenjie Zeng, Anna Ostropolets , et al. · 2023

Background: Common data models solve many challenges of standardizing electronic health record (EHR) data, but are unable to semantically integrate all the resources needed for deep phenotyping. Open Biological and Biomedi…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptional profi…

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment Open

Adrianne L. Stefanski, Michael D. Renecle, Anita Kramer, Shilpi Sehgal, Purnima Narasimhan , et al. · 2022

Preeclampsia is a pregnancy-specific disorder involving placental abnormalities. Elevated placental Sialic acid immunoglobulin-like lectin (Siglec)-6 expression has been correlated with preeclampsia. Siglec-6 is a transmembrane receptor, e…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptional profi…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptional profi…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptional profi…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptional profi…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

<p>Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptio…

Ontologizing Health Systems Data at Scale: Making Translational Discovery a Reality Open

Tiffany J Callahan, Adrianne L. Stefanski, Jordan M Wyrwa, Chenjie Zeng, Anna Ostropolets , et al. · 2022

Background: Common data models solve many challenges of standardizing electronic health record (EHR) data, but are unable to semantically integrate all the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO…

Ontologizing Health Systems Data at Scale: Making Translational Discovery a Reality Open

Tiffany J Callahan, Adrianne L. Stefanski, Jordan M Wyrwa, Chenjie Zeng, Anna Ostropolets , et al. · 2022

Common data models solve many challenges of standardizing electronic health record (EHR) data, but are unable to semantically integrate the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO) Foundry ontolo…

Ontologizing Health Systems Data at Scale: Making Translational Discovery a Reality Open

Tiffany J Callahan, Adrianne L. Stefanski, Jordan M Wyrwa, Chenjie Zeng, Anna Ostropolets , et al. · 2022

<p>Common data models solve many challenges of standardizing electronic health record (EHR) data, but are unable to semantically integrate the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO) Found…

Ontologizing Health Systems Data at Scale: Making Translational Discovery a Reality Open

Tiffany J Callahan, Adrianne L. Stefanski, Jordan M Wyrwa, Chenjie Zeng, Anna Ostropolets , et al. · 2022

Common data models solve many challenges of standardizing electronic health record (EHR) data, but are unable to semantically integrate the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO) Foundry ontolo…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Currently, the only definitive treatment of preeclampsia is delivery of the placenta, which is central to the pathogenesis of the disease. Transcriptional profi…

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome Open

Tiffany J Callahan, Adrianne L. Stefanski, Jin-Dong Kim, William A. Baumgartner, Jordan M Wyrwa , et al. · 2022

Preeclampsia is a leading cause of maternal and fetal morbidity and\nmortality. Currently, the only definitive treatment of preeclampsia is delivery\nof the placenta, which is central to the pathogenesis of the disease.\nTranscriptional pr…

Role of the placenta in health and disease investigations into Siglec-6 and exosomes, The Open

Adrianne L. Stefanski · 2021

Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery Open

Xingmin Zhang, Amy Yates, Nicole Vasilevsky, Jean-Philippe F. Gourdine, Tiffany J Callahan , et al. · 2019

Murine trophoblast-derived and pregnancy-associated exosome-enriched extracellular vesicle microRNAs: Implications for placenta driven effects on maternal physiology Open

Adrianne L. Stefanski, Nadine Martinez, Lisa K. Peterson, Tiffany J Callahan, Eileen P. Treacy , et al. · 2019

The role of extracellular vesicles (EVs), specifically exosomes, in intercellular communication likely plays a key role in placental orchestration of pregnancy and maternal immune sensing of the fetus. While murine models are powerful tool…

Exploring the utility of link prediction algorithms for drug repurposing Open

Tiffany J Callahan, William A. Baumgartner, Adrianne L. Stefanski, Lawrence Hunter, Olivier Bodenreider · 2019

Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery Open

Xingmin Zhang, Amy Yates, Nicole Vasilevsky, Jean-Philippe F. Gourdine, Tiffany J Callahan , et al. · 2019

Electronic Health Record (EHR) systems typically define laboratory test results using the Laboratory Observation Identifier Names and Codes (LOINC) and can transmit them using Fast Healthcare Interoperability Resource (FHIR) standards. LOI…

OWL-NETS: abstracting OWL for network inference Open

Tiffany J Callahan, William A. Baumgartner, Michael Bada, Adrianne L. Stefanski, Ignacio J. Tripodi , et al. · 2019

Identifying and annotating uncharacterized preeclampsia-associated genes Open

Tiffany J Callahan, Adrianne L. Stefanski, William A. Baumgartner, Toyofumi Fujiwara, Jin-Dong Kim , et al. · 2019

Identifying and annotating uninvestigated preeclampsia-related genes using linked open biomedical data Open

Tiffany J Callahan, Adrianne L. Stefanski, William A. Baumgartner, Lawrence Hunter, Toyofumi Fujiwara , et al. · 2019

Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease Open

Breanna Symmes, Adrianne L. Stefanski, Chelsea M. Magin, Christopher M. Evans · 2018

In humans and mice, the first line of innate defense against inhaled pathogens and particles in the respiratory tract is airway mucus. The primary solid components of the mucus layer are the mucins MUC5AC and MUC5B, polymeric glycoproteins…

Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction Open

Jenifer Monks, David J. Orlicky, Adrianne L. Stefanski, Andrew E. Libby, Elise S. Bales , et al. · 2018

The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis Open

Tsukasa Okamoto, Susan Mathai, Corinne E. Hennessy, Laura A. Hancock, Avram Walts , et al. · 2018

The common gain-of-function MUC5B promoter variant ( rs35705950 ) is the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF). While the role of complement in IPF is controversial, both MUC5B and the complement …

Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches Open

Adrianne L. Stefanski, Dorota S. Raclawska, Christopher M. Evans · 2018

OWL-NETS: Transforming OWL Representations for Improved Network Inference Open

Tiffany J Callahan, William A. Baumgartner, Michael Bada, Adrianne L. Stefanski, Ignacio J. Tripodi , et al. · 2017

Our knowledge of the biological mechanisms underlying complex human disease is largely incomplete. While Semantic Web technologies, such as the Web Ontology Language (OWL), provide powerful techniques for representing existing knowledge, w…

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