Adriano Setti
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View article: LncRNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation
LncRNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation Open
A growing body of evidence suggests that tissue-specific lncRNAs play pivotal roles in the heart. Here, we exploit the synteny between the mouse and human genomes to identify the human lncRNA HSCHARME and combine single-cell transcriptomic…
View article: SERTM2: a neuroactive player in the world of micropeptides
SERTM2: a neuroactive player in the world of micropeptides Open
View article: ALS-associated FUS mutation reshapes the RNA and protein composition of stress granules
ALS-associated FUS mutation reshapes the RNA and protein composition of stress granules Open
Stress granules (SG) are part of a cellular protection mechanism where untranslated messenger RNAs and RNA-binding proteins are stored upon conditions of cellular stress. Compositional variations due to qualitative or quantitative protein …
View article: BRCA1 levels and DNA-damage response are controlled by the competitive binding of circHIPK3 or FMRP to the BRCA1 mRNA
BRCA1 levels and DNA-damage response are controlled by the competitive binding of circHIPK3 or FMRP to the BRCA1 mRNA Open
View article: A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain
A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain Open
Functional studies of circular RNAs (circRNAs) began quite recently, and few data exist on their function in vivo. Here, we have generated a knockout (KO) mouse model to study circDlc1(2), a circRNA highly expressed in the prefrontal corte…
View article: CyCoNP lncRNA establishes <i>cis</i> and <i>trans</i> RNA–RNA interactions to supervise neuron physiology
CyCoNP lncRNA establishes <i>cis</i> and <i>trans</i> RNA–RNA interactions to supervise neuron physiology Open
The combination of morphogenetic and transcription factors together with the synergic aid of noncoding RNAs and their cognate RNA binding proteins contribute to shape motor neurons (MN) identity. Here, we extend the noncoding perspective o…
View article: M6A reduction relieves FUS-associated ALS granules
M6A reduction relieves FUS-associated ALS granules Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease due to gradual motoneurons (MN) degeneration. Among the processes associated to ALS pathogenesis, there is the formation of cytoplasmic inclusions produced by a…
View article: M<sup>6</sup>A reduction relieves FUS-associated ALS granules
M<sup>6</sup>A reduction relieves FUS-associated ALS granules Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease due to gradual motorneurons (MN) degeneration 1 . Among the processes associated to ALS pathogenesis, there is the formation of cytoplasmic inclusions produced …
View article: ALS-associated FUS mutation reshapes the RNA and protein composition of Stress Granules
ALS-associated FUS mutation reshapes the RNA and protein composition of Stress Granules Open
Stress Granules (SG) formation is a cellular protection mechanism, constituting a storage for untranslated mRNAs and RNA-binding proteins (RBPs); however, these condensates can turn into pathological aggregates, related to the onset of neu…
View article: The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs
The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs Open
View article: The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart
The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart Open
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associat…
View article: Author response: The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart
Author response: The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart Open
View article: A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment
A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment Open
View article: The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart
The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart Open
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes-of-action are still limited to few examples. We recently identified pCharme, a chromatin-associat…
View article: A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs Open
View article: Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity
Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity Open
View article: Lnc-SMaRT Translational Regulation of Spire1, A New Player in Muscle Differentiation
Lnc-SMaRT Translational Regulation of Spire1, A New Player in Muscle Differentiation Open
The destiny of a messenger RNA is determined from a combination of in cis elements, like peculiar secondary structures, and in trans modulators, such as RNA binding proteins and non-coding, regulatory RNAs. RNA guanine quadruplexes belong …
View article: Trans‐generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy
Trans‐generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy Open
View article: SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase
SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase Open