Adrien Joseph
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View article: Diagnosis of Congestive Acute Kidney Injury With the Use of Ultrasound-Based Venous Congestion Assessment
Diagnosis of Congestive Acute Kidney Injury With the Use of Ultrasound-Based Venous Congestion Assessment Open
View article: Outcomes of Critically Ill Adult Patients With Acute Encephalitis
Outcomes of Critically Ill Adult Patients With Acute Encephalitis Open
Importance Functional outcomes and long-term recovery after severe encephalitis are not well characterized. Objective To determine the incidence of functional disability or death at 3 months and to describe recovery trajectories through 1 …
View article: Optimizing ADAMTS13 prophylaxis to reduce relapse and organ failure in congenital thrombotic thrombocytopenic purpura
Optimizing ADAMTS13 prophylaxis to reduce relapse and organ failure in congenital thrombotic thrombocytopenic purpura Open
Congenital thrombotic thrombocytopenic purpura (cTTP) is caused by a severe inherited ADAMTS13 deficiency. While acute episodes are life-threatening, long-term burden of ischemic complications and effectiveness of prophylactic strategies r…
View article: Immunosuppressive therapy management during sepsis in kidney transplant recipients: a prospective multicenter study
Immunosuppressive therapy management during sepsis in kidney transplant recipients: a prospective multicenter study Open
Background Sepsis is the leading cause of Intensive Care Unit (ICU) admissions in kidney transplant recipients (KTRs). However, the optimal immunosuppressive therapy (IST) management in this context is not well-defined. We aimed to evaluat…
View article: Kidney replacement therapy in critically ill obese patients: an urgent call for precision and evidence-based practice!
Kidney replacement therapy in critically ill obese patients: an urgent call for precision and evidence-based practice! Open
View article: Surgical duration as a factor in postoperative infection rates in orthopedic procedures
Surgical duration as a factor in postoperative infection rates in orthopedic procedures Open
Postoperative infection rates have been reported to be extremely sensitive to the surgical duration, particularly for orthopedic procedures that often require more extensive time and therefore increased exposure to infectious agents. There…
View article: Study protocol and statistical plan for the ICRAKI trial: Intermittent haemodialysis versus continuous renal replacement therapy for severe acute kidney injury in critically ill patients
Study protocol and statistical plan for the ICRAKI trial: Intermittent haemodialysis versus continuous renal replacement therapy for severe acute kidney injury in critically ill patients Open
View article: Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome Open
Cushing’s syndrome is caused by an elevation of endogenous or pharmacologically administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded by the gene diazepam binding inhibitor, Dbi ) stimulates food intake and lipo-anab…
View article: Prise en charge du purpura thrombotique thrombocytopénique congénital à l’ère de la protéine ADAMTS13 recombinante : recommandations du Centre de référence des microangiopathies thrombotiques (CNR-MAT)
Prise en charge du purpura thrombotique thrombocytopénique congénital à l’ère de la protéine ADAMTS13 recombinante : recommandations du Centre de référence des microangiopathies thrombotiques (CNR-MAT) Open
View article: ACBP/DBI neutralization for the experimental treatment of fatty liver disease
ACBP/DBI neutralization for the experimental treatment of fatty liver disease Open
Acyl-CoA binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular checkpoint of autophagy. Here, we report that patients with histologically confirmed metabolic-associated steatohepatitis (MASH) or liver …
View article: Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance Open
View article: Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study
Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study Open
View article: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance Open
View article: Acyl-CoA binding protein for the experimental treatment of anorexia
Acyl-CoA binding protein for the experimental treatment of anorexia Open
Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam binding inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that is secreted in a nonconventional, autophagy-dependent fashion. Here, we show that low A…
View article: Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants Open
View article: Acute kidney injury after CAR-T cell therapy: exploring clinical patterns, management, and outcomes
Acute kidney injury after CAR-T cell therapy: exploring clinical patterns, management, and outcomes Open
Background Acute kidney injury (AKI) has been reported after CAR-T cells, but available data are limited. We sought to describe the incidence of AKI in a cohort of patients hospitalized in the intensive care unit (ICU) following CAR-T cell…
View article: Fluid responsiveness and venous congestion: unraveling the nuances of fluid status
Fluid responsiveness and venous congestion: unraveling the nuances of fluid status Open
View article: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants Open
Background During the first COVID-19 pandemic wave, COVID-19-associated pulmonary aspergillosis (CAPA) has been reported in up to 11–28% of critically ill COVID-19 patients and associated with increased mortality. As new SARS-CoV-2 variant…
View article: Right ventricular injury in patients with COVID-19-related ARDS eligible for ECMO support: a multicenter retrospective study
Right ventricular injury in patients with COVID-19-related ARDS eligible for ECMO support: a multicenter retrospective study Open
View article: Critically Ill Patients with Visceral <i>Nocardia</i> Infection, France and Belgium, 2004–2023
Critically Ill Patients with Visceral <i>Nocardia</i> Infection, France and Belgium, 2004–2023 Open
We studied 50 patients with invasive nocardiosis treated during 2004-2023 in intensive care centers in France and Belgium. Most (65%) died in the intensive care unit or in the year after admission. Nocardia infections should be included in…
View article: Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study
Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study Open
Background In the last decade, Ibrutinib has become the standard of care in the treatment of several lymphoproliferative diseases such as chronic lymphocytic leukemia (CLL) and several non-Hodgkin lymphoma. Beyond Bruton tyrosine kinase in…
View article: How I Treat Tumor Lysis Syndrome
How I Treat Tumor Lysis Syndrome Open
1Department of medical intensive care unit, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France 2INSERM U944, Saint-Louis Research Institute, University of Paris Cité, Paris, France Correspo…
View article: Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study
Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study Open
View article: Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis
Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis Open
Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that is mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associa…
View article: The Specificities of Thrombotic Thrombocytopenic Purpura at Extreme Ages: A Narrative Review
The Specificities of Thrombotic Thrombocytopenic Purpura at Extreme Ages: A Narrative Review Open
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy (TMA) related to a severe ADAMTS13 deficiency, the specific von Willebrand factor (VWF)-cleaving protease. This deficiency is often immune-…
View article: Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome Open
Background The immune form of thrombotic thrombocytopenic purpura (iTTP) and the hemolytic and uremic syndrome (HUS) are two major forms of thrombotic microangiopathy (TMA). Their treatment has been recently greatly improved. In this new e…
View article: DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease Open
DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) is a phylogenetically conserved paracrine inhibitor of macroautophagy/autophagy. As such, DBI/ACBP acts as a pro-aging molecule. Indeed, we observed that the knockout of AC…
View article: High plasma concentrations of acyl‐coenzyme A binding protein (<scp>ACBP</scp>) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of <scp>ACBP</scp>
High plasma concentrations of acyl‐coenzyme A binding protein (<span>ACBP</span>) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of <span>ACBP</span> Open
Autophagy defects accelerate aging, while stimulation of autophagy decelerates aging. Acyl‐coenzyme A binding protein (ACBP), which is encoded by a diazepam‐binding inhibitor (DBI), acts as an extracellular feedback regulator of autophagy.…
View article: Acute Kidney Injury in Cancer Immunotherapy Recipients
Acute Kidney Injury in Cancer Immunotherapy Recipients Open
Cancer immunotherapy has now entered clinical practice and has reshaped the standard of care for many cancer patients. With these new strategies, specific toxicities have emerged, and renal side effects have been described. In this review,…
View article: Author Correction: Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19
Author Correction: Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19 Open
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