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View article: Changes in Alignment at Untreated Vertebral Levels Following Short-Segment Fusion Using Personalized Interbody Cages: Leveraging Personalized Medicine to Reduce the Risk of Reoperation
Changes in Alignment at Untreated Vertebral Levels Following Short-Segment Fusion Using Personalized Interbody Cages: Leveraging Personalized Medicine to Reduce the Risk of Reoperation Open
BACKGROUND: An abnormal postoperative lordosis distribution index (LDI), which quantifies the ratio between the lordosis at L4 to S1 and the lordosis at L1 to S1, contributes to the development of adjacent segment disease and increased rev…
View article: A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model
A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model Open
Background Burns are devastating injuries, carry significant morbidity, and require long-term treatment or multiple reconstructive procedures. Wound healing and secondary insults caused by burn wound conversion are amendable to therapeutic…
View article: Spatial frequency domain imager based on a compact multiaperture camera: testing and feasibility for noninvasive burn severity assessment
Spatial frequency domain imager based on a compact multiaperture camera: testing and feasibility for noninvasive burn severity assessment Open
We demonstrate the potential for SFDI to be translated into compact form factor using a compound-eye camera that is capable of obtaining multiple wavelengths channels simultaneously.
View article: Characterizing reduced scattering coefficient of normal human skin across different anatomic locations and Fitzpatrick skin types using spatial frequency domain imaging
Characterizing reduced scattering coefficient of normal human skin across different anatomic locations and Fitzpatrick skin types using spatial frequency domain imaging Open
Our study is the first report of wide-field mapping of human skin scattering properties across multiple skin types and anatomical locations using SFDI. Measured μs' values varied notably between skin types at wavelengths where absorption f…
View article: Spatial Frequency Domain Imaging (SFDI) of clinical burns: A case report
Spatial Frequency Domain Imaging (SFDI) of clinical burns: A case report Open
While visual assessment by a clinician is the standard of care for burn severity evaluations, new technologies at various stages of development are attempting to add objectivity to this practice by quantifying burn severity. Assessment acc…
View article: Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging
Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging Open
Transplantation of kidneys results in delayed graft function in as many as 40% of cases. During the organ transplantation process, donor kidneys undergo a period of cold ischemic time (CIT), where the organ is preserved with a cold storage…
View article: Spatial frequency domain imaging: a quantitative, noninvasive tool for in vivo monitoring of burn wound and skin graft healing
Spatial frequency domain imaging: a quantitative, noninvasive tool for in vivo monitoring of burn wound and skin graft healing Open
There is a need for noninvasive, quantitative methods to characterize wound healing in the context of longitudinal investigations related to regenerative medicine. Such tools have the potential to inform the assessment of wound status and …
View article: Burn wound classification model using spatial frequency-domain imaging and machine learning
Burn wound classification model using spatial frequency-domain imaging and machine learning Open
Accurate assessment of burn severity is critical for wound care and the course of treatment. Delays in classification translate to delays in burn management, increasing the risk of scarring and infection. To this end, numerous imaging tech…
View article: Impact of hemoglobin breakdown products in the spectral analysis of burn wounds using spatial frequency domain spectroscopy
Impact of hemoglobin breakdown products in the spectral analysis of burn wounds using spatial frequency domain spectroscopy Open
Burn wounds and wound healing invoke several biological processes that may complicate the interpretation of spectral imaging data. Through analysis of spatial frequency domain spectroscopy data (450 to 1000 nm) obtained from longitudinal i…
View article: Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide‐field imaging and conventional immunohistochemistry assays
Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide‐field imaging and conventional immunohistochemistry assays Open
Major complications of diabetes lead to inflammation and oxidative stress, delayed wound healing, and persistent ulcers. The high morbidity, mortality rate, and associated costs of management suggest a need for non‐invasive methods that wi…
View article: Correcting for motion artifact in handheld laser speckle images
Correcting for motion artifact in handheld laser speckle images Open
Laser speckle imaging (LSI) is a wide-field optical technique that enables superficial blood flow quantification. LSI is normally performed in a mounted configuration to decrease the likelihood of motion artifact. However, mounted LSI syst…
View article: Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics
Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics Open
Tissue simulating phantoms can provide a valuable platform for quantitative evaluation of the performance of diffuse optical devices. While solid phantoms have been developed for applications related to characterizing exogenous fluorescenc…
View article: Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer’s disease
Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer’s disease Open
Baseline optical properties are typically assumed in calculating the differential pathlength factor (DPF) of mouse brains, a value used in the modified Beer-Lambert law to characterize an evoked stimulus response. We used spatial frequency…
View article: Utility of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) to non-invasively diagnose burn depth in a porcine model
Utility of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) to non-invasively diagnose burn depth in a porcine model Open
Surgical intervention of second degree burns is often delayed because of the difficulty in visual diagnosis, which increases the risk of scarring and infection. Non-invasive metrics have shown promise in accurately assessing burn depth. He…
View article: Acute discrimination between superficial-partial and deep-partial thickness burns in a preclinical model with laser speckle imaging
Acute discrimination between superficial-partial and deep-partial thickness burns in a preclinical model with laser speckle imaging Open
View article: Evaluating visual perception for assessing reconstructed flap health
Evaluating visual perception for assessing reconstructed flap health Open