Adrienn Vágner
YOU?
Author Swipe
View article: HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumab
HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumab Open
Purpose Positron emission tomography (PET) hybrid imaging targeting HER2 requires antibodies labelled with longer half-life isotopes. With a suitable radiation profile, 52 Mn coupled with DOTAGA as a bifunctional chelator is a potential ca…
View article: Evaluation of the therapeutic efficacy of 213Bi-labelled DOTA-conjugated alpha-melanocyte stimulating hormone peptide analogues in melanocortin-1 receptor positive preclinical melanoma model
Evaluation of the therapeutic efficacy of 213Bi-labelled DOTA-conjugated alpha-melanocyte stimulating hormone peptide analogues in melanocortin-1 receptor positive preclinical melanoma model Open
Melanocortin-1 receptor (MC1-R) targeting alpha-melanocyte stimulating hormone-analogue (α-MSH) biomolecules labelled with α-emitting radiometal seem to be valuable in the targeted radionuclide therapy of MC1-R positive melanoma malignum (…
View article: In Vivo evaluation of newly synthesized 213Bi-conjugated alpha-melanocyte stimulating hormone (α-MSH) peptide analogues in melanocortin-1 receptor (MC1-R) positive experimental melanoma model
In Vivo evaluation of newly synthesized 213Bi-conjugated alpha-melanocyte stimulating hormone (α-MSH) peptide analogues in melanocortin-1 receptor (MC1-R) positive experimental melanoma model Open
Given the rising pervasiveness of melanocortin-1 receptor (MC1-R) positive melanoma malignum (MM) and pertinent metastases, radiolabelled receptor-affine alpha-melanocyte stimulating hormone-analogue (α-MSH analogue) imaging probes would b…
View article: AAZTA‐Like Ligands Bearing Phenolate Arms as Efficient Chelators for <sup>68</sup>Ga Labelling in vitro and in vivo
AAZTA‐Like Ligands Bearing Phenolate Arms as Efficient Chelators for <sup>68</sup>Ga Labelling in vitro and in vivo Open
The introduction of a phenolate pendant arm in place of an acetate on AAZTA‐ and DATA‐like ligands resulted in hepta‐ and hexadentate chelators able to form Ga(III) complexes with thermodynamic stability and kinetic inertness higher than t…
View article: In Vivo Preclinical Assessment of the VEGF Targeting Potential of the Newly Synthesized [52Mn]Mn-DOTAGA-Bevacizumab Using Experimental Cervix Carcinoma Mouse Model
In Vivo Preclinical Assessment of the VEGF Targeting Potential of the Newly Synthesized [52Mn]Mn-DOTAGA-Bevacizumab Using Experimental Cervix Carcinoma Mouse Model Open
Among humanized monoclonal antibodies, bevacizumab specifically binds to vascular endothelial growth factor A (VEGF-A). VEGF-A is an overexpressed biomarker in cervix carcinoma and is involved in the development and maintenance of tumor-as…
View article: In Vivo Evaluation of Newly Synthesized 213Bi-Conjugated Alpha-Melanocyte Stimulating Hormone (a-MSH) Peptide Analogues in Melanocortin-1 Receptor (MC1-R) Positive Experimental Melanoma Model
In Vivo Evaluation of Newly Synthesized 213Bi-Conjugated Alpha-Melanocyte Stimulating Hormone (a-MSH) Peptide Analogues in Melanocortin-1 Receptor (MC1-R) Positive Experimental Melanoma Model Open
View article: CCDC 2115291: Experimental Crystal Structure Determination
CCDC 2115291: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2115292: Experimental Crystal Structure Determination
CCDC 2115292: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Boosting Bismuth(III) Complexation for Targeted α‐Therapy (TAT) Applications with the Mesocyclic Chelating Agent AAZTA**
Boosting Bismuth(III) Complexation for Targeted α‐Therapy (TAT) Applications with the Mesocyclic Chelating Agent AAZTA** Open
Targeted α therapy (TAT) is a promising tool in the therapy of cancer. The radionuclide 213 Bi III shows favourable physical properties for this application, but the fast and stable chelation of this metal ion remains challenging. Herein, …
View article: Boosting Bismuth(III) Complexation for Targeted α‐Therapy (TAT) Applications with the Mesocyclic Chelating Agent AAZTA**
Boosting Bismuth(III) Complexation for Targeted α‐Therapy (TAT) Applications with the Mesocyclic Chelating Agent AAZTA** Open
Targeted α therapy (TAT) is a promising tool in the therapy of cancer. The radionuclide 213 Bi III shows favourable physical properties for this application, but the fast and stable chelation of this metal ion remains challenging. Herein, …
View article: Synthesis, Physicochemical, Labeling and In Vivo Characterization of 44Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe
Synthesis, Physicochemical, Labeling and In Vivo Characterization of 44Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe Open
Hypoxia promotes angiogenesis, which is crucial for tumor growth, and induces malignant progression and increases the therapeutic resistance. Positron emission tomography (PET) enables the detection of the hypoxic regions in tumors using 2…
View article: Synthesis of Novel, Dual-Targeting 68Ga-NODAGA-LacN-E[c(RGDfK)]2 Glycopeptide as a PET Imaging Agent for Cancer Diagnosis
Synthesis of Novel, Dual-Targeting 68Ga-NODAGA-LacN-E[c(RGDfK)]2 Glycopeptide as a PET Imaging Agent for Cancer Diagnosis Open
Radiolabeled peptides possessing an Arg-Gly-Asp (RGD) motif are widely used radiopharmaceuticals for PET imaging of tumor angiogenesis due to their high affinity and selectivity to αvβ3 integrin. This receptor is overexpressed in tumor and…
View article: <i>In Vivo</i> Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography
<i>In Vivo</i> Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography Open
Introduction . Hypoxia‐induced α ν β 3 integrin and aminopeptidase N (APN/CD13) receptor expression play an important role in tumor neoangiogenesis. APN/CD13‐specific 68 Ga‐NOTA‐c(NGR), α ν β 3 integrin‐specific 68 Ga‐NODAGA‐[c(RGD)] 2 , a…
View article: CCDC 1872753: Experimental Crystal Structure Determination
CCDC 1872753: Experimental Crystal Structure Determination Open
View article: CCDC 1872767: Experimental Crystal Structure Determination
CCDC 1872767: Experimental Crystal Structure Determination Open
View article: PIDAZTA: Structurally Constrained Chelators for the Efficient Formation of Stable Gallium‐68 Complexes at Physiological pH
PIDAZTA: Structurally Constrained Chelators for the Efficient Formation of Stable Gallium‐68 Complexes at Physiological pH Open
Two structurally constrained chelators based on a fused bicyclic scaffold, 4‐amino‐4‐methylperhydro‐pyrido[1,2‐ a ][1,4]diazepin‐ N , N ′, N ′‐triacetic acids [(4 R* ,10a S* )‐PIDAZTA ( L1 ) and (4 R* ,10a R* )‐PIDAZTA ( L2 )], were design…
View article: Equilibrium Thermodynamics, Formation, and Dissociation Kinetics of Trivalent Iron and Gallium Complexes of Triazacyclononane-Triphosphinate (TRAP) Chelators: Unraveling the Foundations of Highly Selective Ga-68 Labeling
Equilibrium Thermodynamics, Formation, and Dissociation Kinetics of Trivalent Iron and Gallium Complexes of Triazacyclononane-Triphosphinate (TRAP) Chelators: Unraveling the Foundations of Highly Selective Ga-68 Labeling Open
In order to rationalize the influence of FeIII contamination on labeling with the 68Ga eluted from 68Ge/68Ga-generator, a detailed investigation was carried out on the equilibrium properti…
View article: Improved Efficacy of Synthesizing *M<sup>III</sup>-Labeled DOTA Complexes in Binary Mixtures of Water and Organic Solvents. A Combined Radio- and Physicochemical Study
Improved Efficacy of Synthesizing *M<sup>III</sup>-Labeled DOTA Complexes in Binary Mixtures of Water and Organic Solvents. A Combined Radio- and Physicochemical Study Open
Typically, the synthesis of radiometal-based radiopharmaceuticals is performed in buffered aqueous solutions. We found that the presence of organic solvents like ethanol increased the radiolabeling yields of [68Ga]Ga-DOTA (DOTA …
View article: Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry
Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry Open
Due to its 4 carbonic acid groups being available for bioconjugation, the cyclen tetraphosphinate chelator DOTPI, 1,4,7,10-tetraazacyclododecane-1,4,7, 10-tetrakis[methylene(2-carboxyethylphosphinic acid)], represents an ideal scaffold for…
View article: CCDC 1846696: Experimental Crystal Structure Determination
CCDC 1846696: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1846695: Experimental Crystal Structure Determination
CCDC 1846695: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1846694: Experimental Crystal Structure Determination
CCDC 1846694: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Orvosi diagnosztikában és terápiában alkalmazható fémkomplexek fizikai-kémiai sajátságainak vizsgálata
Orvosi diagnosztikában és terápiában alkalmazható fémkomplexek fizikai-kémiai sajátságainak vizsgálata Open
Munkám során tanulmányoztam a CyAAZTA ligandum néhány alkáliföldfém(II)-, átmenetifém(II)- és lantanida(III)-ionokkal alkotott komplexeinek egyensúlyi és szerkezeti, valamint a gallium(III)- és gadolinium(III)-komplexek kinetikai, illetve …
View article: A rigidified AAZTA‐like ligand as efficient chelator for <sup>68</sup> Ga radiopharmaceuticals
A rigidified AAZTA‐like ligand as efficient chelator for <sup>68</sup> Ga radiopharmaceuticals Open
The new cyclohexane‐fused CyAAZTA ligand was synthesized to increase the structural rigidity of the heptadentate chelator AAZTA with the aim of improving the overall stability of its Ga III complex. The stability constant of Ga(CyAAZTA) − …
View article: High kinetic inertness of a bis-hydrated Gd-complex with a constrained AAZTA-like ligand
High kinetic inertness of a bis-hydrated Gd-complex with a constrained AAZTA-like ligand Open
The GdIII complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness in the class of non-macrocyclic bis hydrated GdIII-complexes and optimal relaxometric performances.
View article: CCDC 1047648: Experimental Crystal Structure Determination
CCDC 1047648: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A shortcut to high-affinity Ga-68 and Cu-64 radiopharmaceuticals: one-pot click chemistry trimerisation on the TRAP platform
A shortcut to high-affinity Ga-68 and Cu-64 radiopharmaceuticals: one-pot click chemistry trimerisation on the TRAP platform Open
The kinetic inertness profile of Cu(ii) complexes of TRAP-conjugates enables simple Cu(ii) removal after click functionalisation and confirms their suitability for Cu-64-PET.