Adrienne H. Brouwers
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View article: Supplementary Figure S3 from [<sup>89</sup>Zr]Zr-DFO-girentuximab and [<sup>18</sup>F]FDG PET/CT to Predict Watchful Waiting Duration in Patients with Metastatic Clear-cell Renal Cell Carcinoma
Supplementary Figure S3 from [<sup>89</sup>Zr]Zr-DFO-girentuximab and [<sup>18</sup>F]FDG PET/CT to Predict Watchful Waiting Duration in Patients with Metastatic Clear-cell Renal Cell Carcinoma Open
Flow-chart patients according to RECIST-defined PD. *All patients had clinical disease progression; no CT-imaging was performed before initiation of systemic treatment ** In total 7 patients choose best supportive care. Three other patient…
View article: 104 Evaluation of whole body CD8+ T cell distribution using an <sup>18</sup> F-labeled PET tracer: phase 1 studies in patients with solid tumors and healthy volunteers
104 Evaluation of whole body CD8+ T cell distribution using an <sup>18</sup> F-labeled PET tracer: phase 1 studies in patients with solid tumors and healthy volunteers Open
View article: Comparative analysis of FES-PET/CT and FDG-PET/CT in patients with ER-positive metastatic invasive lobular breast cancer
Comparative analysis of FES-PET/CT and FDG-PET/CT in patients with ER-positive metastatic invasive lobular breast cancer Open
FES-PET/CT and FDG-PET/CT have a similar detection rate in mILC, and FDG-PET/CT should be used for first-step imaging. However, as more metastases are visible on FES-PET/CT in a considerable part of mILC patients, in case of doubt, an addi…
View article: Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy
Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy Open
Objective Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid tumor, with only 30 new patients annually in the Netherlands. PET imaging provides information on distant metastases, after which tyrosine kinase inhibitors (TKIs…
View article: [18F]FDG PET/CT to reduce the need for sentinel lymph node biopsy in early-stage oral cancer: PETN0-study protocol
[18F]FDG PET/CT to reduce the need for sentinel lymph node biopsy in early-stage oral cancer: PETN0-study protocol Open
Using reliable techniques for detecting lymph node metastases (LNM) in oral squamous cell carcinoma (OSCC) is crucial for adequate neck treatment. Currently, palpation of the neck, computed tomography, magnetic resonance imaging, ultrasoun…
View article: Quantification of 89Zr-immunoPET: Methodological considerations
Quantification of 89Zr-immunoPET: Methodological considerations Open
Patlak analysis accounts for plasma kinetics and reversible signals, enabling more accurate interpretation of 89Zr-immunoPET data than SUV. Wider use of kinetic modelling could enhance quantitative accuracy, support reinterpreta…
View article: The utility of 68Ga-DOTATATE and 18F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer
The utility of 68Ga-DOTATATE and 18F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer Open
Background Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of patients with advanced medullary thyroid cancer (MTC). However, treatment response heterogeneity leads to challenges in predicting individual favoura…
View article: Separation of simultaneously acquired [89Zr]atezolizumab and [18F]FDG PET scans
Separation of simultaneously acquired [89Zr]atezolizumab and [18F]FDG PET scans Open
View article: The value of 18F-FDG PET/CT and 18F-DOPA PET/CT in determining the initial surgical strategy of patients with medullary thyroid cancer
The value of 18F-FDG PET/CT and 18F-DOPA PET/CT in determining the initial surgical strategy of patients with medullary thyroid cancer Open
View article: Toxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer
Toxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer Open
Background Locoregional external beam radiotherapy (EBRT) is selectively used in thyroid cancer patients to induce locoregional control. However, despite technological advances, EBRT remains associated with toxicities. We evaluated thyroid…
View article: Improved Localization of Insulinomas Using<sup>68</sup>Ga-NODAGA-Exendin-4 PET/CT
Improved Localization of Insulinomas Using<sup>68</sup>Ga-NODAGA-Exendin-4 PET/CT Open
Precise anatomic localization of insulinomas is crucial for surgical treatment. Current routine noninvasive imaging techniques, including CT, MRI, and 68Ga-DOTA-somatostatin analog (DOTA-SSA) PET/CT, have limited sensitivity. En…
View article: Update on the Role of [18F]FDOPA PET/CT
Update on the Role of [18F]FDOPA PET/CT Open
[18F]-dihydroxyphenylalanine ([18F]FDOPA) is a radiopharmaceutical used in a broad spectrum of diseases, including neuroendocrine tumors (NETs), congenital hyperinsulinism, parkinsonian syndromes and neuro-oncology. G…
View article: Ultrashort Oncologic Whole-Body [<sup>18</sup>F]FDG Patlak Imaging Using LAFOV PET
Ultrashort Oncologic Whole-Body [<sup>18</sup>F]FDG Patlak Imaging Using LAFOV PET Open
Methods to shorten [18F]FDG Patlak PET imaging procedures ranging from 65-90 to 20-30 min after injection, using a population-averaged input function (PIF) scaled to patient-specific image-derived input function (IDIF) values, w…
View article: Facts and Hopes for PET Imaging–Derived Immunotherapy Biomarkers
Facts and Hopes for PET Imaging–Derived Immunotherapy Biomarkers Open
Current immunotherapies have brought major progress in cancer treatments, but not all patients benefit. Therefore, insight into reasons for treatment failure and optimal biomarkers for patient selection are warranted. Current approved biom…
View article: Molecular imaging supports the development of multispecific cancer antibodies
Molecular imaging supports the development of multispecific cancer antibodies Open
View article: Evaluation of Automatic Segmentation Tools on Low-Dose and Ultra-Low-Dose CT Images in PET/CT Scans
Evaluation of Automatic Segmentation Tools on Low-Dose and Ultra-Low-Dose CT Images in PET/CT Scans Open
The use of Ultra-Low-Dose computed tomography (ULD-CT) in PET/CT imaging is gaining attention due to its potential to significantly reduce radiation exposure, which is crucial for patient safety. Accurate organ segmentation is essential fo…
View article: Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer
Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer Open
Understanding which patients with human epidermal growth factor receptor 2 (HER2)-negative or -low metastatic breast cancer (MBC) benefit from HER2-targeted strategies is urgently needed. We assessed the whole-body heterogeneity of HER2 ex…
View article: Clinical impact of using [ <scp> <sup>18</sup> F </scp> ] <scp>AlF</scp> ‐ <scp>NOTA</scp> ‐octreotide <scp>PET</scp> / <scp>CT</scp> instead of [ <scp> <sup>68</sup> Ga </scp> ]Ga‐ <scp>DOTA</scp> ‐ <scp>SSA PET</scp> / <scp>CT</scp> : Secondary endpoint analysis of a multicenter, prospective trial
Clinical impact of using [ <span> <sup>18</sup> F </span> ] <span>AlF</span> ‐ <span>NOTA</span> ‐octreotide <span>PET</span> / <span>CT</span> instead of [ <span> <sup>68</sup> Ga </span> ]Ga‐ <span>DOTA</span> ‐ <span>SSA PET</span> / <span>CT</span> : Secondary endpoint analysis of a multicenter, prospective trial Open
[ 18 F]AlF‐NOTA‐octreotide ([ 18 F]AlF‐OC) is a promising alternative for [ 68 Ga]Ga‐DOTA‐somatostatin analogs (SSAs) in positron emission tomography (PET) imaging of the somatostatin receptor (SSTR). Our aim is to assess changes in TNM st…
View article: How nuclear imaging changed parathyroid surgical strategies through time
How nuclear imaging changed parathyroid surgical strategies through time Open
View article: Clinically Relevant Germline Variants in Children With Nonmedullary Thyroid Cancer
Clinically Relevant Germline Variants in Children With Nonmedullary Thyroid Cancer Open
Context The underlying genetic cause of nonmedullary thyroid cancer (NMTC) in children is often unknown, hampering both predictive testing of family members and preventive clinical management. Objective Our objectives were to investigated …
View article: Advances and challenges in immunoPET methodology
Advances and challenges in immunoPET methodology Open
Immuno-positron emission tomography (immunoPET) enables imaging of specific targets that play a role in targeted therapy and immunotherapy, such as antigens on cell membranes, targets in the disease microenvironment, or immune cells. The m…
View article: Correlation between Histopathological Prognostic Tumor Characteristics and [18F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer
Correlation between Histopathological Prognostic Tumor Characteristics and [18F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer Open
Background: In metastatic breast cancer (MBC), [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics an…
View article: Molecular imaging predicts lack of T-DM1 response in advanced HER2-positive breast cancer (final results of ZEPHIR trial)
Molecular imaging predicts lack of T-DM1 response in advanced HER2-positive breast cancer (final results of ZEPHIR trial) Open
View article: Ultra‐low dose CT scanning for PET/CT
Ultra‐low dose CT scanning for PET/CT Open
Background The use of computed tomography (CT) for attenuation correction (AC) in whole‐body PET/CT can result in a significant contribution to radiation exposure. This can become a limiting factor for reducing considerably the overall rad…
View article: Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism
Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism Open
View article: Current and Future Use of Long Axial Field-of-View Positron Emission Tomography/Computed Tomography Scanners in Clinical Oncology
Current and Future Use of Long Axial Field-of-View Positron Emission Tomography/Computed Tomography Scanners in Clinical Oncology Open
The latest technical development in the field of positron emission tomography/computed tomography (PET/CT) imaging has been the extension of the PET axial field-of-view. As a result of the increased number of detectors, the long axial fiel…
View article: Patient-Derived Medullary Thyroid Cancer Organoids; a Model for Patient-tailored Drug and PET-Tracer Screening
Patient-Derived Medullary Thyroid Cancer Organoids; a Model for Patient-tailored Drug and PET-Tracer Screening Open
Background Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. PET imaging, with various PET tracers, is performed when distant metastatic disease is suspected. After th…
View article: Long Versus Short Axial Field of View Immuno-PET/CT: Semiquantitative Evaluation for<sup>89</sup>Zr-Trastuzumab
Long Versus Short Axial Field of View Immuno-PET/CT: Semiquantitative Evaluation for<sup>89</sup>Zr-Trastuzumab Open
The purpose of this study was to quantify any differences between the SUVs of 89Zr immuno-PET scans obtained using a PET/CT system with a long axial field of view (LAFOV; Biograph Vision Quadra) compared to a PET/CT system with …
View article: Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography
Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography Open
View article: Abstract 5611: LAG-3 PET imaging in patients with cancer before immune checkpoint inhibitor therapy
Abstract 5611: LAG-3 PET imaging in patients with cancer before immune checkpoint inhibitor therapy Open
Background Immune checkpoint inhibitors (ICIs) can induce durable responses in multiple different tumor types. Lymphocyte activation gene-3 (LAG-3) is one of the immune checkpoints for which therapeutic antibodies are being developed. PET …