Adrienne Manbeck
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View article: Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related psychopathology
Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related psychopathology Open
Avoidance behavior is a prominent and impairing feature of anxiety, obsessive-compulsive, and trauma-related disorders (AD). A transdiagnostic approach to identifying the neural basis of avoidance is a promising avenue to elucidate the het…
View article: Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic
Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic Open
View article: Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic
Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic Open
Background: Efforts to identify risk and resilience factors for anxiety severity and course during the COVID-19 pandemic have focused primarily on demographic rather than psychological variables. Intolerance of uncertainty (IU), a transdia…
View article: Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioning
Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioning Open
Computational models of associative learning posit that negative prediction errors (PEs) arising from the omission of aversive outcomes weaken aversive Pavlovian associations during differential conditioning and extinction. It is possible …
View article: The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study
The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study Open
View article: Neural Substrates of Overgeneralized Conditioned Fear in PTSD
Neural Substrates of Overgeneralized Conditioned Fear in PTSD Open
The results point to evidence of brain-based markers of overgeneralized fear conditioning related to PTSD. These findings provide further understanding of a central yet understudied symptom of trauma-related psychopathology.