Adrienne Y. L. Chan
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View article: Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in Asians With Chronic Hepatitis B Virus Infection
Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in Asians With Chronic Hepatitis B Virus Infection Open
View article: Antiseizure medications consumption in 73 countries and regions from 2012 to 2022: a longitudinal trend study
Antiseizure medications consumption in 73 countries and regions from 2012 to 2022: a longitudinal trend study Open
View article: International Trends in Opioid Prescribing by Age and Sex from 2001 to 2019: An Observational Study Using Population-Based Databases from 18 Countries and One Special Administrative Region
International Trends in Opioid Prescribing by Age and Sex from 2001 to 2019: An Observational Study Using Population-Based Databases from 18 Countries and One Special Administrative Region Open
Opioid prescribing remains unbalanced across geographical regions; however, results suggest a tendency to convergence across countries/regions. Differences in opioid prescribing by sex and age were identified.
View article: Risk of Self-Harm and the Use of Leukotriene Receptor Antagonists and Inhaled Corticosteroids: A Population-Based Study
Risk of Self-Harm and the Use of Leukotriene Receptor Antagonists and Inhaled Corticosteroids: A Population-Based Study Open
Using the self-controlled case series design, which was based on comparisons within a population with both the outcome and exposure of interest, our study does not support an association between self-harm and LTRA or ICS use in patients wi…
View article: Characterisation of a clinical trial–like population of high cardiovascular risk patients prior to myocardial infarction or stroke in the real world: design and protocol for a multidatabase retrospective cohort study
Characterisation of a clinical trial–like population of high cardiovascular risk patients prior to myocardial infarction or stroke in the real world: design and protocol for a multidatabase retrospective cohort study Open
Introduction Cardiovascular (CV) disease is the leading cause of morbidity and mortality globally. Low-density lipoprotein cholesterol (LDL-C) is an important modifiable risk factor of major adverse cardiovascular events. Patients without …
View article: Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study
Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study Open
Objective To estimate the effect of gabapentinoid treatment on self-harm. Design A population based self-controlled case series study. Setting UK Clinical Practice Research Datalink Aurum database linked to the Hospital Episode Statistics …
View article: Global Trends in Analgesic Opioid Use in Pregnancy: A Retrospective Cohort Study
Global Trends in Analgesic Opioid Use in Pregnancy: A Retrospective Cohort Study Open
Background: Pain is common during pregnancy, yet there are few contemporary studies of opioid use in pregnancy. This study aimed to describe prescription analgesic opioid use during pregnancy across four regions: Oceania (New South Wales, …
View article: Lithium Use During Pregnancy in 14 Countries
Lithium Use During Pregnancy in 14 Countries Open
Importance In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used…
View article: Wearable Signals for Diagnosing Attention-Deficit/Hyperactivity Disorder in Adolescents: A Feasibility Study
Wearable Signals for Diagnosing Attention-Deficit/Hyperactivity Disorder in Adolescents: A Feasibility Study Open
View article: Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs Open
View article: Association between prenatal antipsychotic exposure and the risk of attention-deficit/hyperactivity disorder and autism spectrum disorder: a systematic review and meta-analysis
Association between prenatal antipsychotic exposure and the risk of attention-deficit/hyperactivity disorder and autism spectrum disorder: a systematic review and meta-analysis Open
The paucity of evidence regarding the safety of gestational antipsychotic exposure has led to treatment discontinuation in pregnant women with severe mental health conditions. This systematic review and meta-analysis aimed to summarise the…
View article: International diversity in psychotropic medication use
International diversity in psychotropic medication use Open
Several studies investigated various aspects of psychotropic medication use and associated risks. Chapter 2 examined multinational trends in ADHD medication consumption across 64 countries. The results revealed a yearly increase of +9.72% …
View article: Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders
Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders Open
The 15 databases showed good potential for a federated network approach using a common data model. Our study provided publicly accessible information on these databases for those seeking to employ real-world data to facilitate current asse…
View article: Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study
Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study Open
View article: Global trends in the consumption of benzodiazepines and Z-drugs in 67 countries and regions from 2008 to 2018: a sales data analysis
Global trends in the consumption of benzodiazepines and Z-drugs in 67 countries and regions from 2008 to 2018: a sales data analysis Open
Study Objectives To investigate the trends in the consumption of benzodiazepines (BZDs) and Z-drugs at global, regional, and national levels from 2008 to 2018, across 67 countries and regions. Methods This cross-sectional descriptive study…
View article: Attention-deficit/hyperactivity disorder medication consumption in 64 countries and regions from 2015 to 2019: a longitudinal study
Attention-deficit/hyperactivity disorder medication consumption in 64 countries and regions from 2015 to 2019: a longitudinal study Open
This project was funded by a grant from the Hong Kong Research Grants Council Collaborative Research Fund (project number C7009-19G).
View article: Trends of polypharmacy among older people in Asia, Australia and the United Kingdom: a multinational population-based study
Trends of polypharmacy among older people in Asia, Australia and the United Kingdom: a multinational population-based study Open
Background Polypharmacy among older people represents a global challenge due to its association with adverse drug events. The reported prevalence of polypharmacy varies widely across countries, and is particularly high in Asian countries. …
View article: Attention deficit hyperactivity disorder, physical abuse and methylphenidate treatment in children
Attention deficit hyperactivity disorder, physical abuse and methylphenidate treatment in children Open
View article: Maternal Benzodiazepines and Z-Drugs Use during Pregnancy and Adverse Birth and Neurodevelopmental Outcomes in Offspring: A Population-Based Cohort Study
Maternal Benzodiazepines and Z-Drugs Use during Pregnancy and Adverse Birth and Neurodevelopmental Outcomes in Offspring: A Population-Based Cohort Study Open
Introduction: The use of benzodiazepines and/or z-drugs in women of childbearing age has increased. Objective: The aim of the study was to evaluate whether gestational benzodiazepine and/or z-drug exposure is associated with adverse birth …
View article: Prenatal exposure to antidepressants or antipsychotics and the risk of seizure in children
Prenatal exposure to antidepressants or antipsychotics and the risk of seizure in children Open
Perinatal mental health problems account for a substantial health burden across the world. Almost one in two women aged under 25 report some form of common mental disorders during pregnancy1. The use of psychotropic medications, especially…
View article: Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019: a longitudinal study
Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019: a longitudinal study Open
Previous studies have reported an extremely unbalanced global access to opioid analgesics. We aimed to determine contemporary trends and patterns of opioid analgesic consumption at the global, regional, and national levels.We analysed the …
View article: Postmarketing safety of orphan drugs: a longitudinal analysis of the US Food and Drug Administration database between 1999 and 2018
Postmarketing safety of orphan drugs: a longitudinal analysis of the US Food and Drug Administration database between 1999 and 2018 Open
View article: Pain assessment tools in paediatric palliative care: A systematic review of psychometric properties and recommendations for clinical practice
Pain assessment tools in paediatric palliative care: A systematic review of psychometric properties and recommendations for clinical practice Open
Background: Assessing pain in infants, children and young people with life-limiting conditions remains a challenge due to diverse patient conditions, types of pain and often a reduced ability or inability of patients to communicate verball…
View article: Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age
Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age Open
In this cohort study, the findings did not suggest that prenatal antipsychotics exposure increased the risk of ADHD, ASD, or small for gestational age. In the primary analysis, there was a small increased risk of preterm birth, but additio…
View article: Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong
Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong Open
Objectives Data linkage of cohort-based data and electronic health records (EHRs) has been practised in many countries, but in Hong Kong there is still a lack of such research. To expand the use of multisource data, we aimed to identify a …
View article: Access and Unmet Needs of Orphan Drugs in 194 Countries and 6 Areas: A Global Policy Review With Content Analysis
Access and Unmet Needs of Orphan Drugs in 194 Countries and 6 Areas: A Global Policy Review With Content Analysis Open
View article: Application of Healthcare ‘Big Data’ in CNS Drug Research: The Example of the Neurological and mental health Global Epidemiology Network (NeuroGEN)
Application of Healthcare ‘Big Data’ in CNS Drug Research: The Example of the Neurological and mental health Global Epidemiology Network (NeuroGEN) Open
View article: Short- and potential long-term adverse health outcomes of COVID-19: a rapid review
Short- and potential long-term adverse health outcomes of COVID-19: a rapid review Open
The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of patients infected worldwide and indirectly affecting even more individuals through disruption of daily living. Long-term adverse outcomes have been reported with …
View article: Short- and potential long-term adverse health outcomes of COVID-19: a rapid review
Short- and potential long-term adverse health outcomes of COVID-19: a rapid review Open
The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of patients infected worldwide and indirectly affecting even more individuals through disruption of daily living. Long-term adverse outcomes have been reported with …
View article: Orphan drugs—access and unmet needs in 194 countries and six regions: a comprehensive policy review with content analysis
Orphan drugs—access and unmet needs in 194 countries and six regions: a comprehensive policy review with content analysis Open