Abhijit Joshi
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View article: The Rise of Artificial Intelligence in Enterprise Resource Planning Software: Enhancing Supply Chain Management Efficiency through Predictive Analytics
The Rise of Artificial Intelligence in Enterprise Resource Planning Software: Enhancing Supply Chain Management Efficiency through Predictive Analytics Open
Enterprise Resource Planning platforms have experienced remarkable evolution through artificial intelligence incorporation, fundamentally restructuring supply chain administration and operational effectiveness throughout various commercial…
View article: Signature Verification using SVM Classifier
Signature Verification using SVM Classifier Open
This review examines the use of Support Vector Machine (SVM) classification for automated handwritten signature verification, a vital aspect of biometric authentication and fraud detection. Addressing challenges like intra-class variations…
View article: Medulloblastoma therapy: Consensus treatment recommendations from SIOP-Europe and the European Reference Network
Medulloblastoma therapy: Consensus treatment recommendations from SIOP-Europe and the European Reference Network Open
The treatment of medulloblastoma has evolved considerably over the last 10 years. Treatment intensity is now stratified within clinical trials, using risk-associated clinical features and molecular biomarkers, aimed at maximising cure rate…
View article: Deep Fraud Net: A Deep Learning Approach for Cyber Security and Financial Fraud Detection and Classification
Deep Fraud Net: A Deep Learning Approach for Cyber Security and Financial Fraud Detection and Classification Open
Given the growing dependence on digital systems and the escalation of financial fraud occurrences, it is imperative to implement efficient cyber security protocols and fraud detection methodologies. The threat's dynamic nature often challe…
View article: Harnessing the Quantum Flux: Architecting and Implementing Real - Time Data Streaming Pipelines with Apache Kafka, Apache Flink, and Cloud - Native Solutions
Harnessing the Quantum Flux: Architecting and Implementing Real - Time Data Streaming Pipelines with Apache Kafka, Apache Flink, and Cloud - Native Solutions Open
The rapid evolution of data technologies has ushered in an era where real -time data streaming is pivotal for modern enterprises. This paper delves into the architectures and technologies that enable real -time data streaming, focusing on …
View article: Augmented Analytics: Leveraging AI and Machine Learning for Enhanced Data Insights
Augmented Analytics: Leveraging AI and Machine Learning for Enhanced Data Insights Open
Augmented analytics is an emerging field that leverages artificial intelligence (AI) and machine learning (ML) to transform the landscape of data analysis. By automating complex data processing tasks, augmented analytics enables organizati…
View article: Adopting Zero Trust Architecture in Data Engineering: Implementing Secure, Trustless Systems for Modern Data Security
Adopting Zero Trust Architecture in Data Engineering: Implementing Secure, Trustless Systems for Modern Data Security Open
The ever-evolving landscape of data engineering necessitates robust security measures to protect sensitive information in distributed environments. Traditional security paradigms, which rely heavily on perimeter defenses, are increasingly …
View article: Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development
Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development Open
Medulloblastoma is currently subclassified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing (RNA-seq) in large, well-annotated cohorts of medulloblastoma, we show that transc…
View article: Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development
Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development Open
Summary Medulloblastoma is currently sub-classified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA-seq in large well annotated cohorts of medulloblastoma we show that transcriptionall…
View article: Federated Learning: Enhancing Data Privacy and Security in Machine Learning through Decentralized Training Paradigms
Federated Learning: Enhancing Data Privacy and Security in Machine Learning through Decentralized Training Paradigms Open
Federated learning represents a transformative paradigm in the realm of machine learning by enabling models to be trained across multiple decentralized devices or servers holding local data samples without exchanging them. This approach si…
View article: Developmental delay and progressive seizures in 2‐month‐old child with diffuse MRI abnormalities
Developmental delay and progressive seizures in 2‐month‐old child with diffuse MRI abnormalities Open
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View article: The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia
The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia Open
Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacores…
View article: Intracerebral schwannoma of the angular gyrus: case report
Intracerebral schwannoma of the angular gyrus: case report Open
We report an intracerebral schwannoma originating in the angular gyrus of a 20-year-old female that was incidentally diagnosed after she presented with a post-traumatic seizure. After comprehensive investigations, including functional magn…
View article: Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse
Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse Open
Background Less than 5% of medulloblastoma (MB) patients survive following failure of contemporary radiation-based therapies. Understanding the molecular drivers of medulloblastoma relapse (rMB) will be essential to improve outcomes. Initi…
View article: Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics
Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics Open
Aims Application of advanced molecular pathology in rare tumours is hindered by low sample numbers, access to specialised expertise/technologies and tissue/assay QC and rapid reporting requirements. We assessed the feasibility of co‐ordina…
View article: MBRS-44. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY
MBRS-44. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY Open
Disease relapse occurs in ~30% of children with medulloblastoma, and is fatal in the majority. We sought to establish whether clinico-molecular characteristics at diagnosis are associated with the nature of relapse, subsequent disease-cour…
View article: The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second‐generation subtypes
The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second‐generation subtypes Open
Aims Biomarker‐driven therapies have not been developed for infant medulloblastoma (iMB). We sought to robustly sub‐classify iMB, and proffer strategies for personalized, risk‐adapted therapies. Methods We characterized the iMB molecular l…
View article: Advanced Cryptographic Techniques for Cloud Data Security: A Technical Exploration into State-of-the-Art Encryption Methodologies Including Homomorphic Encryption, Quantum-Resistant Algorithms, and Hardware Security Modules for Protecting Cloud Data
Advanced Cryptographic Techniques for Cloud Data Security: A Technical Exploration into State-of-the-Art Encryption Methodologies Including Homomorphic Encryption, Quantum-Resistant Algorithms, and Hardware Security Modules for Protecting Cloud Data Open
This paper presents a comprehensive guide on advanced data encryption techniques for cloud security, focusing on the latest encryption methods and their practical applications. The discussion delves into homomorphic encryption, quantum-res…
View article: Brain pseudotumour secondary to Behçet’s disease
Brain pseudotumour secondary to Behçet’s disease Open
Neuro-Behçet’s disease (NBD) is a serious manifestation of Behçet’s disease (BD) and can affect either the central or peripheral nervous systems, or both. It occurs in 10–50% of patients with BD. We report on a patient with an unusual intr…
View article: MBCL-30. SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA
MBCL-30. SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA Open
Understanding the specific molecular pathology of infant medulloblastoma (iMB) is urgently required to inform contemporary treatments, risk-stratification and clinical trials. Comprehensive analysis incorporating central clinical/ patholog…
View article: MEDU-06. NOVEL MOLECULAR SUBGROUPS IMPROVE CLINICAL CLASSIFICATION AND OUTCOME PREDICTION FOR CHILDHOOD MEDULLOBLASTOMA
MEDU-06. NOVEL MOLECULAR SUBGROUPS IMPROVE CLINICAL CLASSIFICATION AND OUTCOME PREDICTION FOR CHILDHOOD MEDULLOBLASTOMA Open
\nBACKGROUND: International consensus recognises four medulloblastoma molecular subgroups - WNT (MBWNT), SHH (MBSHH), Group 3 (MBGrp3) and Group 4 (MBGrp4) - each defined by their characteristic genome-wide transcriptomic and DNA methylomi…
View article: MEDU-09. SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA
MEDU-09. SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA Open
Systematic characterisation of the molecular pathology of infant medulloblastoma (iMB), particularly in relation to the consensus molecular subgroups and outcomes, is urgently required to inform contemporary treatments, risk-stratification…
View article: MEDU-16. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT
MEDU-16. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT Open
Medulloblastoma relapse occurs in 30–40% of patients, is typically fatal, and accounts for ~10% of childhood cancer deaths. We undertook a comprehensive characterisation of the clinical features of medulloblastoma recurrence (e.g. time-to-…