Allen W. Song
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View article: The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment Open
INTRODUCTION The Consortium for Clarity in Alzheimer's disease related dementias (ADRD) Research Through Imaging (CLARiTI) is a study that aims to collect standardized imaging and plasma biomarkers on 2000 Clinical Core participants enroll…
View article: Study Protocol: Single-Blinded, Controlled, Clinical Trial Evaluating the Feasibility of Spinal Cord Stimulation for Improving Neuropathic Pain and Rehabilitation Outcomes in Patients With Thoracic Spinal Cord Injury
Study Protocol: Single-Blinded, Controlled, Clinical Trial Evaluating the Feasibility of Spinal Cord Stimulation for Improving Neuropathic Pain and Rehabilitation Outcomes in Patients With Thoracic Spinal Cord Injury Open
BACKGROUND AND OBJECTIVES: Traumatic thoracic spinal cord injury (SCI) is complicated by chronic neuropathic pain and neurological deficits including bowel and bladder dysfunction. Treatment with spinal cord stimulation (SCS) has demonstra…
View article: A Large-Scale Vision-Language Dataset Derived from Open Scientific Literature to Advance Biomedical Generalist AI
A Large-Scale Vision-Language Dataset Derived from Open Scientific Literature to Advance Biomedical Generalist AI Open
Despite the excitement behind biomedical artificial intelligence (AI), access to high-quality, diverse, and large-scale data - the foundation for modern AI systems - is still a bottleneck to unlocking its full potential. To address this ga…
View article: Amphetamine in Adolescence Induces a Sex-Specific Mesolimbic Dopamine Phenotype in the Adult Prefrontal Cortex
Amphetamine in Adolescence Induces a Sex-Specific Mesolimbic Dopamine Phenotype in the Adult Prefrontal Cortex Open
Drugs of abuse in adolescence impact brain maturation and increase psychiatric risk, with differences in sensitivity between males and females. Amphetamine in adolescent male, but not female mice, causes dopamine axons intended to innervat…
View article: Modulation of netrin-1/DCC signaling pathway by Jiawei Kongsheng Zhenzhong Pill improves synaptic structural plasticity in PSD rats
Modulation of netrin-1/DCC signaling pathway by Jiawei Kongsheng Zhenzhong Pill improves synaptic structural plasticity in PSD rats Open
Jiawei Kongsheng Zhenzhong Pill(JKZP) is based on Kongsheng Zhenzhong Pill contained in the Tang Dynasty's "Thousand Golden Prescriptions," which exhibited good anti-ischemic and antidepressant effects in the previous study. However, its s…
Visible-Light-Mediated Aerobic α-Oxygenation of Tetrahydroisoquinolines and Isoindolines Without External Photocatalysts Open
A visible-light-mediated strategy for the direct oxygenation of N-substituted tetrahydroisoquinolines and isoindolines to the corresponding benzo-fused lactams under clean conditions without using any external photocatalysts has been devel…
MAU-Net: Full-period Mango Leaf Disease Image Segmentation Algorithm Based on an Improved UNet Network Open
Mango leaf disease segmentation is an essential foundation for accurate disease diagnosis and intelligent grading. The size and shape of mango leaf diseases vary significantly at different times, making it difficult for mainstream semantic…
View article: BIOMEDICA: An Open Biomedical Image-Caption Archive, Dataset, and Vision-Language Models Derived from Scientific Literature
BIOMEDICA: An Open Biomedical Image-Caption Archive, Dataset, and Vision-Language Models Derived from Scientific Literature Open
The development of vision-language models (VLMs) is driven by large-scale and diverse multimodal datasets. However, progress toward generalist biomedical VLMs is limited by the lack of annotated, publicly accessible datasets across biology…
High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition Open
Magnetic resonance imaging studies using diffusion-weighted imaging suggest that age-related cognitive decline and alterations in brain function, in healthy adults, are at least partly explained by the degradation of white matter pathways …
View article: Predicting risk of impending cognitive decline in asymptomatic individuals with early Alzheimer’s disease: Insights from cortical diffusion MRI
Predicting risk of impending cognitive decline in asymptomatic individuals with early Alzheimer’s disease: Insights from cortical diffusion MRI Open
Neurodegeneration associated with Alzheimer’s disease (AD) can start at the microstructural level years before cognitive symptoms; yet, it has been difficult to definitively detect these early changes to plan effective treatments. Using a …
Low intensity focused ultrasound stimulation in stroke: A phase I safety & feasibility trial Open
Our phase-I safety study suggests that one session of LIFUS up to 8 W/cm2 ISPPA is safe and feasible in stroke patients, and LIFUS at high intensity induces positive changes in both MSL and corticospinal excitability. The next logical step…
Low-intensity focused ultrasound stimulation in stroke: An intensity escalation phase I safety and feasibility study Open
BACKGROUND Low-intensity focused ultrasound stimulation (LIFUS) has recently emerged as a promising neuromodulation tool for certain neuropsychiatric diseases. However, its safety and feasibility in stroke patients remains unknown. Intensi…
View article: Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer’s disease
Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer’s disease Open
In addition to amyloid beta plaques and neurofibrillary tangles, Alzheimer’s disease (AD) has been associated with elevated iron in deep gray matter nuclei using quantitative susceptibility mapping (QSM). However, only a few studies have e…
View article: Flexible <scp>multi‐purpose</scp> integrated <scp>RF</scp>/shim coil array for <scp>MRI</scp> and localized <scp><i>B</i><sub>0</sub></scp> shimming
Flexible <span>multi‐purpose</span> integrated <span>RF</span>/shim coil array for <span>MRI</span> and localized <span><i>B</i><sub>0</sub></span> shimming Open
Purpose To develop a flexible, lightweight, and multi‐purpose integrated parallel reception, excitation, and shimming (iPRES) coil array that can conform to the subject's anatomy and perform MR imaging and localized B 0 shimming in differe…
High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging Open
Healthy neurocognitive aging has been associated with the microstructural degradation of white matter pathways that connect distributed gray matter regions, assessed by diffusion-weighted imaging (DWI). However, the relatively low spatial …
View article: Numerical simulations of an integrated radio-frequency/wireless coil design for simultaneous acquisition and wireless transfer of magnetic resonance imaging data
Numerical simulations of an integrated radio-frequency/wireless coil design for simultaneous acquisition and wireless transfer of magnetic resonance imaging data Open
Objective. A novel magnetic resonance imaging (MRI) radio-frequency (RF) coil design, termed an integrated RF/wireless (iRFW) coil design, can simultaneously perform MRI signal reception and far-field wireless data transfer with the same c…
Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving an umbilical cord blood infusion Open
Diffusion tensor imaging (DTI) has been used as an outcome measure in clinical trials for several psychiatric disorders but has rarely been explored in autism clinical trials. This is despite a large body of research suggesting altered whi…
An <span>iPRES‐W</span> Coil Array for Simultaneous Imaging and Wireless Localized <span><i>B</i><sub>0</sub></span> Shimming of the Cervical Spinal Cord Open
Purpose To develop a wireless integrated parallel reception, excitation, and shimming (iPRES‐W) coil array for simultaneous imaging and wireless localized B 0 shimming, and to demonstrate its ability to correct for distortions in DTI of th…
Cortical iron mediates <span>age‐related</span> decline in fluid cognition Open
Brain iron dyshomeostasis disrupts various critical cellular functions, and age‐related iron accumulation may contribute to deficient neurotransmission and cell death. While recent studies have linked excessive brain iron to cognitive func…
Recent Advances in Radio‐Frequency Coil Technologies: Flexible, Wireless, and Integrated Coil Arrays Open
Radio‐frequency (RF) coils are to magnetic resonance imaging (MRI) scanners what eyes are to the human body. Because of their critical importance, there have been constant innovations driving the rapid development of RF coil technologies. …
Application of an integrated radio‐frequency/shim coil technology for signal recovery in fMRI Open
Purpose Gradient‐echo echo‐planar imaging (EPI), which is typically used for blood oxygenation level‐dependent (BOLD) functional MRI (fMRI), suffers from distortions and signal loss caused by localized B 0 inhomogeneities. Such artifacts c…
<span>DTI</span> Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients During Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure Open
Background Previous studies using diffusion tensor imaging (DTI)‐based connectome analysis revealed improved connectivity in cerebral palsy (CP) patients who underwent autologous umbilical cord blood (UCB) stem‐cell therapy. However, the p…
Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature Open
Ollivier–Ricci curvature is a method for measuring the robustness of connections in a network. In this work, we use curvature to measure changes in robustness of brain networks in children with autism spectrum disorder (ASD). In an open la…
Frontal Hypoactivation During a Working Memory Task in Children With 22q11 Deletion Syndrome Open
Impairments in executive function, such as working memory, are almost universal in children with chromosome 22q11.2 deletion syndrome. Delineating the neural underpinnings of these functions would enhance understanding of these impairments…
Measuring Robustness of Brain Networks in Autism Spectrum Disorder with Ricci Curvature Open
Ricci curvature is a method for measuring the robustness of networks. In this work, we use Ricci curvature to measure robustness of brain networks affected by autism spectrum disorder (ASD). Subjects with ASD are given a stem cell infusion…