Aeneas Kolev
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View article: Phenotypical differences of neutrophils patrolling tumour-draining lymph nodes in head and neck cancer
Phenotypical differences of neutrophils patrolling tumour-draining lymph nodes in head and neck cancer Open
View article: Allergic sensitization does not influence advancement or survival in oral cancer
Allergic sensitization does not influence advancement or survival in oral cancer Open
View article: 941 Tumour draining lymph nodes contain immunosuppressive B cell phenotypes
941 Tumour draining lymph nodes contain immunosuppressive B cell phenotypes Open
Background Check point inhibitor (CPI) treatment has revolutionized cancer management. However, many patients do not respond or do not show long-lasting remission. Therefore, we need to understand the mechanisms behind the anti-cancer resp…
View article: Regulatory B cells producing IL‐10 are increased in human tumor draining lymph nodes
Regulatory B cells producing IL‐10 are increased in human tumor draining lymph nodes Open
The contribution of different immune cell subsets, especially T cells, in anti‐tumor immune response is well established. In contrast to T cells, the anti‐tumor contribution of B cells has been scarcely investigated. B‐cells are often over…
View article: Sentinel <scp>node‐assisted</scp> neck dissection in advanced oral squamous cell carcinoma—A new protocol for staging and treatment
Sentinel <span>node‐assisted</span> neck dissection in advanced oral squamous cell carcinoma—A new protocol for staging and treatment Open
Background Sentinel lymph node biopsy (SLNB) is used to improve the staging of and guide treatment in patients with early‐stage T1–T2 N0 oral squamous cell carcinoma (OSCC). The role of sentinel nodes (SNs) and the use of SN‐technique in a…
View article: Tumour-draining lymph nodes in head and neck cancer are characterized by accumulation of CTLA-4 and PD-1 expressing Treg cells
Tumour-draining lymph nodes in head and neck cancer are characterized by accumulation of CTLA-4 and PD-1 expressing Treg cells Open
View article: CD4<sup>+</sup> and CD8<sup>+</sup> T cells in sentinel nodes exhibit distinct pattern of PD‐1, CD69, and HLA‐DR expression compared to tumor tissue in oral squamous cell carcinoma
CD4<sup>+</sup> and CD8<sup>+</sup> T cells in sentinel nodes exhibit distinct pattern of PD‐1, CD69, and HLA‐DR expression compared to tumor tissue in oral squamous cell carcinoma Open
Anticancer immunotherapies have revolutionized cancer management, yet the effect of systemic anti‐programmed cell death protein 1 (PD‐1) treatment is predominantly studied in tumor‐infiltrating lymphocytes (TILs). Its impact on PD‐1 expres…
View article: Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8 – Risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas
Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8 – Risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas Open
Our results indicate a risk of misclassification of patients with otherOPSCC and low TNM-8 stage. We suggest that p16 should only be evaluated in TSCC/BOTSCC and that patients with otherOPSCC should all be staged as patients with HPV-unrel…
View article: Immune related proteins and tumor infiltrating<scp>CD8</scp>+ lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (<scp>HPV</scp>) and clinical outcome
Immune related proteins and tumor infiltrating<span>CD8</span>+ lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (<span>HPV</span>) and clinical outcome Open
Background Hypopharyngeal cancer (HPSCC) shows a poor clinical outcome, while HPSCC, caused by human papillomavirus (HPV), presents a better outcome. Here, HPCC, immune proteins, and tumor infiltrating CD8+ lymphocytes (CD8+ TILs) were eva…
View article: Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome
Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome Open
Human papillomavirus (HPV) is a major etiological factor for tonsillar and the base of tongue cancer (TSCC/BOTSCC). HPV-positive and HPV-negative TSCC/BOTSCC present major differences in mutations, mRNA expression and clinical outcome. Ear…