Amand F. Schmidt
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View article: Risk of cancer following presentation with new-onset atrial fibrillation using data from UK national databases
Risk of cancer following presentation with new-onset atrial fibrillation using data from UK national databases Open
Aims Atrial fibrillation (AF) and cancer are both highly prevalent conditions and are known to be associated. Our aim was to identify predictors and develop models for all cancer types, in men and women, and for the four most common cancer…
View article: Proteomics-based clustering outperforms clinical clustering in identifying people with heart failure with distinct outcomes
Proteomics-based clustering outperforms clinical clustering in identifying people with heart failure with distinct outcomes Open
Background Heart failure (HF) clustering typically relies on clinical characteristics which may not reflect underlying pathophysiology relevant for personalized medicine. We aimed to identify plasma protein profiles of HF patients with red…
View article: Smoking as a Risk Factor for Cardiovascular Disease in Females and Males: Observational and Mendelian Randomisation Analyses in the UK Biobank
Smoking as a Risk Factor for Cardiovascular Disease in Females and Males: Observational and Mendelian Randomisation Analyses in the UK Biobank Open
Introduction: Observational studies have shown that smoking is more strongly associated with cardiovascular disease (CVD) in females than in males. It remains unclear whether these observed sex differences reflect differences in the causal…
View article: Proteomics-based clustering outperforms clinical clustering in identifying heart failure patient groups with distinct outcomes
Proteomics-based clustering outperforms clinical clustering in identifying heart failure patient groups with distinct outcomes Open
Background. Clustering of heart failure (HF) patients typically relies on clinical characteristics, which may not reflect underlying pathophysiology relevant for personalised medicine. We aimed to identify plasma protein profiles of HF pat…
View article: Genetically informed drug target prioritisation and repurposing for major depressive disorder
Genetically informed drug target prioritisation and repurposing for major depressive disorder Open
Major depressive disorder (MDD) treatments have limited efficacy and target few mechanisms, highlighting the need for innovative drug discovery. Drugs targeting genetically supported proteins are 2.6 times more likely to succeed in drug de…
View article: Myosin inhibitors for treatment of hypertrophic cardiomyopathy
Myosin inhibitors for treatment of hypertrophic cardiomyopathy Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the effects of myosin inhibitors compared to usual care or placebo on exercise capacity, need for septal reduction therapy,…
View article: Accurate machine learning-based CVD risk prediction in primary care may reduce the need for routine health care checks
Accurate machine learning-based CVD risk prediction in primary care may reduce the need for routine health care checks Open
Background: Cardiovascular risk prediction models, such as PCE, QRISK3, and SCORE2 are recommended tools to guide treatment initiation/intensification in primary care. In clinical practice, the absence of one or more required predictors is…
View article: Diabetes, glycaemic traits and cardiovascular disease in females and males: Observational and Mendelian randomisation analyses in the <scp>UK</scp> Biobank
Diabetes, glycaemic traits and cardiovascular disease in females and males: Observational and Mendelian randomisation analyses in the <span>UK</span> Biobank Open
Introduction Observational studies have shown that the association between type 2 diabetes and cardiovascular disease (CVD) is stronger in females than in males. It remains unclear whether the causal effects of diabetes and glycaemic trait…
View article: Clustering of electronic health records in atrial fibrillation patients and impact on prognosis and patient trajectories: a UK linked-dataset study
Clustering of electronic health records in atrial fibrillation patients and impact on prognosis and patient trajectories: a UK linked-dataset study Open
Aims Atrial fibrillation (AF) is characterized by heterogeneity in presentation, comorbidity profile and prognosis, with different AF subphenotypes having been previously suggested. Mental health disorders are common in the AF population. …
View article: Addressing common inferential mistakes when failing to reject the null-hypothesis
Addressing common inferential mistakes when failing to reject the null-hypothesis Open
Failure to reject a null-hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests …
View article: Identifying and ranking non-traditional risk factors for cardiovascular disease prediction in people with type 2 diabetes
Identifying and ranking non-traditional risk factors for cardiovascular disease prediction in people with type 2 diabetes Open
Background Cardiovascular disease ( CVD) prediction models perform poorly in people with type 2 diabetes (T2DM). We aimed to identify potentially non-traditional CVD predictors for six facets of CVD (including coronary heart disease, ische…
View article: Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records
Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records Open
Aims Atrial fibrillation (AF) is a frequent comorbidity in heart failure (HF). We analysed factors associated with new‐onset atrial fibrillation in patients with heart failure using linked real‐world UK data from primary and secondary care…
View article: Addressing common inferential mistakes when failing to reject the null-hypothesis
Addressing common inferential mistakes when failing to reject the null-hypothesis Open
Failure to reject a null-hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests …
View article: Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions
Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions Open
Mendelian randomisation is an approach in genetic epidemiology that uses genetic variants as instrumental variables to investigate the causal relationship between genetically proxied exposures and health outcomes. During the last years, th…
View article: Causes of death in patients with atrial fibrillation in the UK: a nationwide electronic health record study
Causes of death in patients with atrial fibrillation in the UK: a nationwide electronic health record study Open
Aims Causes of death remain largely unexplored in the atrial fibrillation (AF) population. We aimed to (i) thoroughly assess causes of death in patients with AF, especially those associated with sudden cardiac death (SCD) and (ii) evaluate…
View article: Impact of pulmonary vein isolation on atrial arrhythmias in patients with typical atrial flutter: systematic review and meta-analysis of randomized clinical trials
Impact of pulmonary vein isolation on atrial arrhythmias in patients with typical atrial flutter: systematic review and meta-analysis of randomized clinical trials Open
Aims Cavotricuspid isthmus (CTI) ablation is the current ablation treatment for typical atrial flutter (AFL). However, post-ablation atrial tachyarrhythmias, mostly in the form of atrial fibrillation (AF), are frequently observed after CTI…
View article: Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease
Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease Open
Introduction Urinary metabolism breakdown products reflect metabolic changes in atherosclerosis-relevant tissues and may contain relevant therapeutic leads. We integrated data on urinary metabolism breakdown products, plasma proteins, athe…
View article: Addressing common inferential mistakes when failing to reject the null-hypothesis
Addressing common inferential mistakes when failing to reject the null-hypothesis Open
Failure to reject a null hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests …
View article: Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating <i>MYBPC3</i> Founder Variant Carriers
Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating <i>MYBPC3</i> Founder Variant Carriers Open
BACKGROUND: MYBPC3 founder variants cause hypertrophic cardiomyopathy leading to heart failure and malignant ventricular arrhythmias. Exercise is typically regarded as a risk factor for disease expression although evidence is conflicting. …