Mohammad A. Uddin
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View article: Hsp90 inhibition protects brain endothelial cells against <scp>LPS</scp>‐induced injury
Hsp90 inhibition protects brain endothelial cells against <span>LPS</span>‐induced injury Open
Dysfunction of the blood–brain barrier (BBB) endothelium increases infiltration of lymphocytes and innate immune cells in the brain, leading to the development of neurological disorders. Heat shock protein 90 (Hsp90) inhibitors are anti‐in…
View article: Tunicamycin Protects against LPS-Induced Lung Injury
Tunicamycin Protects against LPS-Induced Lung Injury Open
The pulmonary endothelium is a dynamic semipermeable barrier that orchestrates tissue-fluid homeostasis; regulating physiological and immunological responses. Endothelial abnormalities are caused by inflammatory stimuli interacting with in…
View article: Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis
Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis Open
Endothelial barrier dysfunction (EBD) is the hallmark of Acute Respiratory Distress Syndrome (ARDS), a potentially lethal respiratory disorder associated with the COVID-19 - related deaths. Herein, we employed a cecal ligation and puncture…
View article: Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs
Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs Open
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) cause thousands of deaths every year and are associated with high mortality rates (~40%) due to the lack of efficient therapies. Understanding the molecular mechanisms …
View article: Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs
Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs Open
Growth hormone releasing hormone (GHRH) antagonists enhance endothelial barrier function and counteract the LPS-induced lung endothelial hyperpermeability, the cardinal feature of the acute respiratory distress syndrome (ARDS). The unfolde…
View article: P53 is Subjected to Lipoteichoic Acid-Induced Phosphorylation in the Lungs
P53 is Subjected to Lipoteichoic Acid-Induced Phosphorylation in the Lungs Open
P53 is a transcription factor protecting the cells against malignancies via modulation of multifarious regulatory signaling cascades. Those activities may result to either cellular repair, or to the elimination of the irreversible damaged …
View article: Effects of Heat Shock Protein 90 Inhibition In the Lungs
Effects of Heat Shock Protein 90 Inhibition In the Lungs Open
Inhibition of Hsp90 is associated with anti-inflammatory effects. We employed human lung microvascular endothelial cells to investigate the effects of the Hsp90 inhibitors 17-AAG, AUY-922 and 17-DMAG in the unfolded protein response (UPR) …
View article: Autophagy, unfolded protein response and lung disease
Autophagy, unfolded protein response and lung disease Open
Acute Respiratory Distress Syndrome is a severe disorder affecting thousands of individuals worldwide. The available medical countermeasures do not sufficiently suppress the unacceptable high mortality rates associated with those in need. …
View article: P53 versus inflammation: an update
P53 versus inflammation: an update Open
Etiologies of human pathophysiology have been associated with states of severe inflammation. The endothelium defender P53 supports cellular functions, by orchestrating anti-inflammatory responses. The purpose of the present article is to p…
View article: GHRH antagonists support lung endothelial barrier function
GHRH antagonists support lung endothelial barrier function Open
Growth Hormone-Releasing Hormone (GHRH) regulates the release of growth hormone from the anterior pituitary gland. GHRH also acts as a growth and inflammatory factor in a variety of experimental models in oncology. In the current study, we…
View article: P53-induced reduction of lipid peroxidation supports brain microvascular endothelium integrity
P53-induced reduction of lipid peroxidation supports brain microvascular endothelium integrity Open
Dysregulation of the blood brain barrier due to oxidative stress causes neurological disorders, such as Alzheimer's and Parkinson's disease. We employed brain microvascular endothelial cells; to investigate the effects of P53 towards the l…
View article: Unfolded protein response regulates P53 expression in the pulmonary endothelium
Unfolded protein response regulates P53 expression in the pulmonary endothelium Open
Lung endothelial barrier dysfunction leads to severe pathologies, including the lethal Acute Respiratory Distress Syndrome. P53 has been associated with anti‐inflammatory activities. The current study employs a variety of unfolded protein …
View article: P53: The endothelium defender
P53: The endothelium defender Open
P53 represents the paradigm of a multitalented transcription factor, responsible for the cellular defense against a plethora of potentially harmful stimuli. It exercises the ability to strongly oppose both cancer and inflammation, partiall…
View article: Group B Streptococcus among Pregnant Women and Newborns in Mirzapur, Bangladesh: Colonization, Vertical Transmission, and Serotype Distribution
Group B Streptococcus among Pregnant Women and Newborns in Mirzapur, Bangladesh: Colonization, Vertical Transmission, and Serotype Distribution Open
Group B streptococcus (GBS) infection is a leading cause of death among newborns in developed countries. Data on the burden of GBS in Asian countries are lacking. This study aimed to understand (i) the rate of maternal rectovaginal GBS car…