Afnan Shakoori
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View article: Evaluating the pentapharmacological potency of otamixaban against lung cancer CDK2, transferase, oxidoreductase and signalling proteins
Evaluating the pentapharmacological potency of otamixaban against lung cancer CDK2, transferase, oxidoreductase and signalling proteins Open
Lung cancer remains the leading cause of cancer-related mortality worldwide. With approximately 2.2 million new cases and 1.8 million deaths annually, it contributes to 18% of all cancer fatalities. The high mortality rate, limited accessi…
View article: Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer
Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer Open
Cervical cancer, primarily caused by persistent infection with high-risk human papillomavirus strains, leads to abnormal cell growth in the cervix. Globally, it accounts for over 600,000 new cases and 340,000 deaths annually, with the high…
View article: Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction‐associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways
Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction‐associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways Open
Although single treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) or vitamin D 3 (VD 3 ) inhibited metabolic dysfunction‐associated steatohepatitis (MASH) development in diabetic patients, their combination has not been exp…
View article: Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of pharmacokinetic properties prediction of ADME
Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of pharmacokinetic properties prediction of ADME Open
Background & objectives: Quantum chemical and molecular docking practices deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 ( Plasmodium falciparum 3D7). Fu…
View article: Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics Investigation
Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics Investigation Open
Inflammatory Bowel Diseases (IBD), which encompass ulcerative colitis (UC) and Crohn’s disease (CD), are characterized by chronic inflammation and tissue damage of the gastrointestinal tract. This study aimed to uncover novel disease-gene …
View article: Molecular docking of daunorubicin and etoposide drugs against Leishmania donovani: A theoretical study
Molecular docking of daunorubicin and etoposide drugs against Leishmania donovani: A theoretical study Open
Background & objectives: The human blood parasite Leishmania donovani causes visceral leishmaniasis or grayish discoloration of the skin (black fever/kala-azar). Antitumor drugs such as daunorubicin and etoposide can help to treat such dis…
View article: Artemisia annua Extract Attenuate Doxorubicin-Induced Hepatic Injury via PI-3K/Akt/Nrf-2-Mediated Signaling Pathway in Rats
Artemisia annua Extract Attenuate Doxorubicin-Induced Hepatic Injury via PI-3K/Akt/Nrf-2-Mediated Signaling Pathway in Rats Open
Doxorubicin (DOX), which is used to treat cancer, has harmful effects that limit its therapeutic application. Finding preventative agents to thwart DOX-caused injuries is thus imperative. Artemisia annua has numerous biomedical uses. This …
View article: Isoform switching leads to downregulation of cytokine producing genes in estrogen receptor positive breast cancer
Isoform switching leads to downregulation of cytokine producing genes in estrogen receptor positive breast cancer Open
Objective: Estrogen receptor breast cancer (BC) is characterized by the expression of estrogen receptors. It is the most common cancer among women, with an incidence rate of 2.26 million cases worldwide. The aim of this study was to identi…
View article: P32 Gene PCR Evaluation for Capripox’s Diagnostic Potential and Immunogenic Effect
P32 Gene PCR Evaluation for Capripox’s Diagnostic Potential and Immunogenic Effect Open
Capripoxviruses are a group of extremely contagious viruses that cause substantial economic losses in livestock, especially goats and sheep.The purpose of this investigation was to determine the genetic diversity, antigenicity, and docking…
View article: Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals
Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals Open
Lactoferrin (LF) is a protein found in several bodily fluids, such as milk. This protein has a diverse range of functions and is evolutionarily conserved. Lactoferrin is a multifunction protein with distinct biological abilities affecting …
View article: Applying the CRISPR/Cas9 for Treating Human and Animal Diseases – Comprehensive Review
Applying the CRISPR/Cas9 for Treating Human and Animal Diseases – Comprehensive Review Open
Recently, genome editing tools have been extensively used in many biomedical sciences. The gene editing system is applied to modify the dnA sequences in the cellular system to comprehend their physiological response. A developing genome ed…
View article: Impacts of chitosan and its nanoformulations on the metabolic syndromes: a review
Impacts of chitosan and its nanoformulations on the metabolic syndromes: a review Open
A significant public health issue worldwide is metabolic syndrome, a cluster of metabolic illnesses that comprises insulin resistance, obesity, dyslipidemia, hyperglycemia, and hypertension. The creation of natural treatments and preventio…