Afroze Abbas
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View article: Assessing and Managing Primary Hyperparathyroidism and Fracture Risk in England: A Survey of Medical Professionals
Assessing and Managing Primary Hyperparathyroidism and Fracture Risk in England: A Survey of Medical Professionals Open
Purpose To describe diagnostic approaches and management strategies for patients with primary hyperparathyroidism (PHPT) and recent fracture in England. Methods We developed a survey based on a patient at high fracture risk and a new diagn…
View article: Comparison of Leptin and Tnf-Α Levels in Type 2 Diabetes Mellitus Patients with and Without Obesity
Comparison of Leptin and Tnf-Α Levels in Type 2 Diabetes Mellitus Patients with and Without Obesity Open
Background: Leptin and tumor necrosis factor alpha (TNF-α) are the main adipokine products of adipose tissue, leptin is a hormone that controls appetite, while TNF-α acts as a proinflammatory cytokine that can cause Insulin resistance Lept…
View article: 7281 Increased Incidence Of Fracture And Predicted Fracture Risk In Patients With Mild Autonomous Cortisol Secretion
7281 Increased Incidence Of Fracture And Predicted Fracture Risk In Patients With Mild Autonomous Cortisol Secretion Open
Disclosure: R. Sagar: None. A. Saadulla: None. A. Abbas: None. Background: Mild autonomous cortisol secretion (MACS) is common in patients presenting with adrenal incidentalomas (AI) and has been associated with cardiovascular and metaboli…
View article: Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia
Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia Open
Context The causative link between circulating glucocorticoid excess and osteoporosis is well-established. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which increases local cortisol production, is expressed in human oste…
View article: A randomised controlled pilot trial of oral 11β-HSD1 inhibitor AZD4017 for wound healing in adults with type 2 diabetes mellitus
A randomised controlled pilot trial of oral 11β-HSD1 inhibitor AZD4017 for wound healing in adults with type 2 diabetes mellitus Open
Chronic wounds (e.g. diabetic foot ulcers) have a major impact on quality of life, yet treatments remain limited. Glucocorticoids impair wound healing; preclinical research suggests that blocking glucocorticoid activation by the enzyme 11β…
View article: Adrenal Incidentaloma
Adrenal Incidentaloma Open
An adrenal incidentaloma is now established as a common endocrine diagnosis that requires a multidisciplinary approach for effective management. The majority of patients can be reassured and discharged, but a personalized approach based up…
View article: MON-189 Evaluation of Adrenal Insufficiency and Recovery in Rheumatology Patients on Long-Term Glucocorticoid Therapy
MON-189 Evaluation of Adrenal Insufficiency and Recovery in Rheumatology Patients on Long-Term Glucocorticoid Therapy Open
Background Long-term glucocorticoid (GC) therapy is commonly used to treat rheumatological conditions. This may result in tertiary adrenal insufficiency, as a result of suppression of the HPA axis, when GC doses are weaned/withdrawn. There…
View article: Glucose monitoring in diabetes: from clinical studies to real‐world practice
Glucose monitoring in diabetes: from clinical studies to real‐world practice Open
Lowering glucose levels in diabetes prevents microvascular complications and long‐term macrovascular disease. HbA 1c has long been used to guide management decisions, but it fails to address hypoglycaemia and glycaemic variability, both of…
View article: A rare case of hypercalcaemia: Double trouble, with a twist
A rare case of hypercalcaemia: Double trouble, with a twist Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Responding to Acute Care Needs of Patients With Cancer: Recent Trends Across Continents
Responding to Acute Care Needs of Patients With Cancer: Recent Trends Across Continents Open
Remarkable progress has been made over the past decade in cancer medicine. Personalized medicine, driven by biomarker predictive factors, novel biotherapy, novel imaging, and molecular targeted therapeutics, has improved outcomes. Cancer i…
View article: An observational study of patient characteristics and mortality following hypoglycemia in the community
An observational study of patient characteristics and mortality following hypoglycemia in the community Open
Objectives Characterize patients with diabetes with severe hypoglycemia requiring emergency services intervention at home and investigate 12-month mortality. Research design and methods Emergency services call-outs for hypoglycemia were re…