Agata A. Exner
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View article: A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis
A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis Open
View article: In vivo tracking of CAR-T cells in tumors via nanobubble-based contrast enhanced ultrasound
In vivo tracking of CAR-T cells in tumors via nanobubble-based contrast enhanced ultrasound Open
Summary CAR-T cell therapy has led to remarkable advances in the outcomes of patients with acute lymphoblastic leukemia (ALL), B cell lymphomas, and multiple myeloma. Given these successes in hematologic malignancies, extensive efforts are…
View article: Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles
Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles Open
Tumors often exhibit an extracellular matrix with elevated stiffness due to excessive accumulation and crosslinking of proteins, particularly collagen. This elevated stiffness acts as a physical barrier, impeding the infiltration of immune…
View article: Evaluating the Effect of Drug Loading on the Acoustic Response of Nanobubbles in Stable and Inertial Cavitation Regimes
Evaluating the Effect of Drug Loading on the Acoustic Response of Nanobubbles in Stable and Inertial Cavitation Regimes Open
Nanobubbles (NBs) have been investigated as ultrasound contrast agents and drug delivery carriers in medical applications. Previous studies have reported the efficacy of NBs in imaging and therapy. However, ultrasound (US) exposure paramet…
View article: Experimental investigation on the effect of concentration on the resonance frequency of lipid coated ultrasonically excited microbubbles
Experimental investigation on the effect of concentration on the resonance frequency of lipid coated ultrasonically excited microbubbles Open
View article: The dance of the nanobubbles: detecting acoustic backscatter from sub-micron bubbles using ultra-high frequency acoustic microscopy
The dance of the nanobubbles: detecting acoustic backscatter from sub-micron bubbles using ultra-high frequency acoustic microscopy Open
Nanobubbles have gained attention for their use as highly stable ultrasound (US) contrast agents, but assessment of individual nanobubble size remains a challenge. Current sizing techniques require either extensive sample preparation or de…
View article: Decorrelation Time Mapping as an Analysis Tool for Nanobubble-Based Contrast Enhanced Ultrasound Imaging
Decorrelation Time Mapping as an Analysis Tool for Nanobubble-Based Contrast Enhanced Ultrasound Imaging Open
Nanobubbles (NBs; ~100-500 nm diameter) are preclinical ultrasound (US) contrast agents that expand applications of contrast enhanced US (CEUS). Due to their sub-micron size, high particle density, and deformable shell, NBs in pathological…
View article: Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy
Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy Open
The field of medical ultrasound has undergone a significant evolution since the development of microbubbles as contrast agents. However, due to their size, microbubbles remain in the vasculature, and therefore have limited clinical applica…
View article: Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique
Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique Open
Nano-sized shell-stabilized gas bubbles have applications in various fields ranging from environmental science to biomedical engineering. A resonant mass measurement (RMM) technique is demonstrated here as a new and only method capable of …
View article: Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components
Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components Open
Nanoscale ultrasound contrast agents, or nanobubbles, are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in cancer. These sub-micron particles are approximately 10x smaller th…
View article: The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles
The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles Open
Investigation of nanobubble (NB) pharmacokinetics in contrast-enhanced ultrasound (CEUS) at the pixel level shows a unique phenomenon where the first pass of the contrast agent bolus is accompanied by a second wave. This effect has not bee…
View article: Contrast Enhanced Ultrasound Imaging by Nature-Inspired Ultrastable Echogenic Nanobubbles
Contrast Enhanced Ultrasound Imaging by Nature-Inspired Ultrastable Echogenic Nanobubbles Open
Advancement of ultrasound molecular imaging applications requires not only a reduction in size of the ultrasound contrast agents (UCAs) but also a significant improvement in the in vivo stability of the shell-stabilized gas bubble. The tra…
View article: Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced Ultrasound
Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced Ultrasound Open
With a typical 100-500 nm diameter, nanobubbles are a promising new-generation ultrasound contrast agent that paves ways for several applications, such as efficient drug delivery, molecular imaging, and assessment of vascular permeability.…
View article: In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors
In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors Open
In situ forming implants (ISFIs) allow for a high initial intratumoral concentration and sustained release of the chemotherapeutic. However, clinical translation is impeded primarily due to limited drug penetration from the tumor/boundary …
View article: Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique
Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique Open
Nano-sized shell-stabilized gas bubbles have applications in various fields ranging from environmental science to biomedical engineering. A resonant mass measurement (RMM) technique is demonstrated here as a new and only method capable of …
View article: Pickering Bubbles as Dual-Modality Ultrasound and Photoacoustic Contrast Agents
Pickering Bubbles as Dual-Modality Ultrasound and Photoacoustic Contrast Agents Open
Microbubbles (MBs) stabilized by particle surfactants (i.e., Pickering bubbles) have better thermodynamic stability compared to MBs stabilized by small molecules as a result of steric hindrance against coalescence, higher diffusio…
View article: Pharmacokinetic modeling of PSMA-targeted nanobubbles for quantification of extravasation and binding in mice models of prostate cancer
Pharmacokinetic modeling of PSMA-targeted nanobubbles for quantification of extravasation and binding in mice models of prostate cancer Open
Purpose Contrast-enhanced ultrasound (CEUS) by injection of microbubbles (MBs) has shown promise as a cost-effective imaging modality for prostate cancer (PCa) detection. More recently, nanobubbles (NBs) have been proposed…
View article: Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment
Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment Open
The development of novel anticancer therapies warrants the parallel development of biomarkers that can quantify their effectiveness. Photoacoustic imaging has the potential to measure changes in tumor vasculature during treatment. Establis…
View article: The dance of the nanobubbles: detecting acoustic backscatter from sub-micron bubbles using ultra-high frequency acoustic microscopy
The dance of the nanobubbles: detecting acoustic backscatter from sub-micron bubbles using ultra-high frequency acoustic microscopy Open
Nanobubbles have gained attention for their use as highly stable ultrasound (US) contrast agents, but assessment of individual nanobubble size remains a challenge. Current sizing techniques require either extensive sample preparation or de…
View article: Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment
Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment Open
The development of novel anticancer therapies warrants the parallel development of biomarkers that can quantify their effectiveness. Photoacoustic imaging has the potential to measure changes in tumor vasculature during treatment. Establis…
View article: The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles
The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles Open
Investigation of nanobubble (NB) pharmacokinetics in contrast-enhanced ultrasound (CEUS) at the pixel level shows a unique phenomenon where the first pass of the contrast agent bolus is accompanied by a second wave. This effect has not bee…
View article: Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components
Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components Open
Nanoscale ultrasound contrast agents, or nanobubbles, are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in cancer. These sub-micron particles are approximately 10x smaller th…
View article: Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy
Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy Open
The field of medical ultrasound has undergone a significant evolution since the development of microbubbles as contrast agents. However, due to their size, microbubbles remain in the vasculature, and therefore have limited clinical applica…
View article: Contrast Enhanced Ultrasound Imaging by Nature-Inspired Ultrastable Echogenic Nanobubbles
Contrast Enhanced Ultrasound Imaging by Nature-Inspired Ultrastable Echogenic Nanobubbles Open
Advancement of ultrasound molecular imaging applications requires not only a reduction in size of the ultrasound contrast agents (UCAs) but also a significant improvement in the in vivo stability of the shell-stabilized gas bubble. The tra…
View article: Nanobubble Contrast Enhanced Ultrasound Imaging: A Review
Nanobubble Contrast Enhanced Ultrasound Imaging: A Review Open
Contrast‐enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, and it continues to evolve and develop through innovative technological advancements. Clinically utilized contrast agents for u…
View article: Heterogeneous Kinetics of Nanobubble Ultrasound Contrast Agent and Angiogenic Signaling in Head and Neck Cancer
Heterogeneous Kinetics of Nanobubble Ultrasound Contrast Agent and Angiogenic Signaling in Head and Neck Cancer Open
Recently developed nanobubble ultrasound contrast agents are a promising tool for imaging and drug delivery in tumors. To better understand their unusual kinetics, we implemented a novel pixel clustering analysis, which provides unique inf…
View article: Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions Open
In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting in several approved drugs and multiple promising candidates in clinical trials. Regulatory agencies such as the Food and …
View article: Multispecies comparative prostate anatomy by imaging: Implications for experimental models of prostatic disease
Multispecies comparative prostate anatomy by imaging: Implications for experimental models of prostatic disease Open
Background There is an increasing interest in using preclinical models for development and assessment of medical devices and imaging techniques for prostatic disease care. Still, a comprehensive assessment of the prostate's radiological an…
View article: Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound
Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound Open
Nanomedicine in oncology has not had the success in clinical impact that was anticipated in the early stages of the field's development. Ideally, nanomedicines selectively accumulate in tumor tissue and reduce systemic side effects compare…
View article: Abstract No. 323 Hitting the Bull’s Eye: A Nanoscale PSMA-Targeted Ultrasound Contrast Agent (UCA) for Prostate Cancer Molecular Imaging
Abstract No. 323 Hitting the Bull’s Eye: A Nanoscale PSMA-Targeted Ultrasound Contrast Agent (UCA) for Prostate Cancer Molecular Imaging Open