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View article: Target deconvolution of HDAC pharmacopoeia highlights MBLAC2 as common off-target
Target deconvolution of HDAC pharmacopoeia highlights MBLAC2 as common off-target Open
HDAC drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a chemical proteomics assay using three promiscuous chemotypes and quantitative mass spectrometry …