Agnes E. Wold
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View article: Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery
Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery Open
Background The gut microbiota may influence immune maturation during infancy. While cesarean delivery is known to delay acquisition of a mature anaerobic microbiota, the influence of being firstborn on early gut colonization is less well s…
View article: Food and nutrient intake at 1 year of age in Northern Sweden: results from the Swedish NICE birth cohort
Food and nutrient intake at 1 year of age in Northern Sweden: results from the Swedish NICE birth cohort Open
Dietary habits and nutrient intake early in life are important for long-term health. Here, we examine food and nutrient intake at 1 year of age in the Swedish NICE (Nutritional impact on Immunological maturation during Childhood in relatio…
View article: Tracing <i>Staphylococcus capitis</i> and <i>Staphylococcus epidermidis</i> strains causing septicemia in extremely preterm infants to the skin, mouth, and gut microbiota
Tracing <i>Staphylococcus capitis</i> and <i>Staphylococcus epidermidis</i> strains causing septicemia in extremely preterm infants to the skin, mouth, and gut microbiota Open
Coagulase-negative staphylococci (CoNS) comprise about 50 species, some of which cause septicemia in preterm neonates. CoNS establish early on the skin and in the oral and gut microbiota, from where they may spread to the bloodstream. The …
View article: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy
Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy Open
Background Children growing up on farms or with pets have a lower risk of developing allergy, which may be linked to their gut microbiota development during infancy. Methods Children from the FARMFLORA birth cohort (N = 65), of whom 28 (43…
View article: Associations of gestational and childhood exposure to lead, cadmium, and fluoride with cognitive abilities, behavior, and social communication at 4 years of age: NICE birth cohort study
Associations of gestational and childhood exposure to lead, cadmium, and fluoride with cognitive abilities, behavior, and social communication at 4 years of age: NICE birth cohort study Open
Despite non-significant associations, both lead and cadmium exposure showed consistent inverse associations with cognitive abilities at 4 years, whereas associations with behavioral problems were less conclusive, especially for cadmium. Re…
View article: Biomarker Candidates of Habitual Food Intake in a Swedish Cohort of Pregnant and Lactating Women and Their Infants
Biomarker Candidates of Habitual Food Intake in a Swedish Cohort of Pregnant and Lactating Women and Their Infants Open
Circulating food metabolites could improve dietary assessments by complementing traditional methods. Here, biomarker candidates of food intake were identified in plasma samples from pregnancy (gestational week 29, N = 579), delivery (mothe…
View article: Short-chain fatty acids (SCFA) in infants’ plasma and corresponding mother’s milk and plasma in relation to subsequent sensitisation and atopic disease
Short-chain fatty acids (SCFA) in infants’ plasma and corresponding mother’s milk and plasma in relation to subsequent sensitisation and atopic disease Open
Swedish Research Council (Nr. 2013-3145, 2019-0137 and 2023-02217 to A-S.S.), Swedish Research Council for Health, Working Life and Welfare FORTE, Nr 2018-00485 to A.W.), The Swedish Asthma and Allergy Association's Research Fund (2020-002…
View article: Toxic metals and essential trace elements in placenta and their relation to placental function
Toxic metals and essential trace elements in placenta and their relation to placental function Open
Among the toxic metals, lead appeared to negatively impact placental weight and cobalt decreased placental mtDNAcn. Joint essential element concentrations increased placental mtDNAcn. Manganese also appeared to increase placental weight, b…
View article: LC-MS-Based Metabolomics for Dietary Biomarker Discovery in a Cohort of Pregnant and Lactating Women and Their Infants
LC-MS-Based Metabolomics for Dietary Biomarker Discovery in a Cohort of Pregnant and Lactating Women and Their Infants Open
Circulating food metabolites could improve dietary assessment by complementing more traditional, subjective methods. However, information is lacking on the accuracy of these objective markers during pregnancy and lactation. The objective o…
View article: Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort
Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort Open
Introduction: Allergies and other immune-mediated diseases are thought to result from incomplete maturation of the immune system early in life. We previously showed that infants’ metabolites at birth were associated with immune cell subtyp…
View article: Mediation by Thyroid Hormone in the Relationships Between Gestational Exposure to Methylmercury and Birth Size
Mediation by Thyroid Hormone in the Relationships Between Gestational Exposure to Methylmercury and Birth Size Open
Our previous studies have linked gestational methylmercury exposure, originating from seafood, to changes in maternal thyroid hormones and infant birth size in a Swedish birth cohort. Herein we aimed to determine associations between mater…
View article: Risk factors for psychiatric readmission among inpatients with major depressive disorder: A patient-chart based study
Risk factors for psychiatric readmission among inpatients with major depressive disorder: A patient-chart based study Open
Introduction Major depressive disorder (MDD) is a common and severe mental disorder. Although inpatient care may be needed in some cases, little is known on which factors are associated with risk for readmission. Objectives To identify ris…
View article: Staphylococcus aureus sequence type (ST) 45, ST30, and ST15 in the gut microbiota of healthy infants — persistence and population counts in relation to ST and virulence gene carriage
Staphylococcus aureus sequence type (ST) 45, ST30, and ST15 in the gut microbiota of healthy infants — persistence and population counts in relation to ST and virulence gene carriage Open
Staphylococcus aureus colonizes the anterior nares, and also the gut, particularly in infants. S. aureus is divided into lineages, termed clonal complexes (CCs), which comprise closely related sequence types (STs). While CC30 and CC45 pred…
View article: Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn’s Disease and Coexistent Orofacial Granulomatosis
Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn’s Disease and Coexistent Orofacial Granulomatosis Open
The results support the notion that CD in conjunction with OFG represents a specific phenotype of CD that is characterized by frequent perianal disease, pronounced intestinal granuloma formation and a need for extensive therapy.
View article: Association of maternal fluoride exposure during pregnancy with increased size at birth and the potential mediation effect by maternal thyroid hormones: the Swedish NICE birth cohort
Association of maternal fluoride exposure during pregnancy with increased size at birth and the potential mediation effect by maternal thyroid hormones: the Swedish NICE birth cohort Open
BACKGROUND AND AIM: Observational studies have indicated that maternal fluoride exposure during gestation may impair child neurodevelopment but a potential impact on birth outcomes is understudied. The aim of the study is to evaluate the i…
View article: Association of maternal urinary fluoride concentrations during pregnancy with size at birth and the potential mediation effect by maternal thyroid hormones: The Swedish NICE birth cohort
Association of maternal urinary fluoride concentrations during pregnancy with size at birth and the potential mediation effect by maternal thyroid hormones: The Swedish NICE birth cohort Open
Gestational urinary fluoride concentrations were associated with increased size at birth and even with increased odds of being born large for gestational age. The fluoride-related associations with increased size at birth were not explaine…
View article: Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity
Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity Open
Umbilical cord blood is frequently used in health monitoring of the neonate. Results may be affected by the proportion of arterial and venous cord blood, the venous blood coming from the mother to supply oxygen and nutrients to the infant,…
View article: Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias Open
Self-selection to the NICE study was evident in some factors related to lifestyle and socioeconomic characteristics but did not appear to skew pregnancy outcomes or alter well-known effects of certain lifestyle parameters on pregnancy outc…
View article: Infant Iodine and Selenium Status in Relation to Maternal Status and Diet During Pregnancy and Lactation
Infant Iodine and Selenium Status in Relation to Maternal Status and Diet During Pregnancy and Lactation Open
Iodine and selenium are essential trace elements. Recent studies indicate that pregnant and lactating women often have insufficient intake of iodine and selenium, but the impact on fetal and infant status is unclear. Here, we assessed iodi…
View article: Low Concentration of Fecal Valeric Acid at 1 Year of Age Is Linked with Eczema and Food Allergy at 13 Years of Age: Findings from a Swedish Birth Cohort
Low Concentration of Fecal Valeric Acid at 1 Year of Age Is Linked with Eczema and Food Allergy at 13 Years of Age: Findings from a Swedish Birth Cohort Open
Background: Short-chain fatty acids (SCFAs) are abundant bacterial metabolites in the gut, with immunomodulatory properties. Hence, they may influence allergy development. Previous studies have linked fecal SCFA pattern during infancy with…
View article: Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life Open
Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the prop…