Agnes Oetting
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View article: Tissue microarray analyses of the essential DNA repair factors ATM, DNA-PKcs and Ku80 in head and neck squamous cell carcinoma
Tissue microarray analyses of the essential DNA repair factors ATM, DNA-PKcs and Ku80 in head and neck squamous cell carcinoma Open
Background Head and neck squamous cell carcinoma (HNSCC) negative for Human Papillomavirus (HPV) has remained a difficult to treat entity, whereas tumors positive for HPV are characterized by radiosensitivity and favorable patient outcome.…
View article: Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1
Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1 Open
View article: The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma
The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma Open
View article: MEDB-50. Assessment of cellular radiosensitivity and DNA repair in medulloblastoma cell lines and patient-derivded xenograft slice cultures
MEDB-50. Assessment of cellular radiosensitivity and DNA repair in medulloblastoma cell lines and patient-derivded xenograft slice cultures Open
Medulloblastoma (WHO grade 4) is the most common malignant brain tumor of childhood. Despite the high importance of radiotherapy for disease control, the mechanisms underlying response and resistance to radiotherapy are incompletely unders…
View article: Die prognostische Bedeutung von Axl und Gas6 bei Kopf-Hals-Karzinomen
Die prognostische Bedeutung von Axl und Gas6 bei Kopf-Hals-Karzinomen Open
Einleitung Die Rezeptor-Tyrosinkinase Axl wird als Treiber für Migration und Metastasierung, sowie als Resistenzfaktor gegen zielgerichtete, sowie Radio- und Chemotherapien (RCT) bei verschiedenen Entitäten, einschließlich HNSCC, beschrieb…
View article: Die prognostische Bedeutung von B7-H3 und B7-H4 bei Kopf-Hals-Karzinomen
Die prognostische Bedeutung von B7-H3 und B7-H4 bei Kopf-Hals-Karzinomen Open
Einleitung Immuncheckpointi-Ihibition ist eine valide Therapieoption in diversen Tumorentitäten. Die Inhibition der PD1/PD-L1 (B7-H1) Achse ist Erstlinientherapie für r/m HNSCC und wird aktuell auch im kurativen Setting getestet. Hier habe…
View article: The prognostic impact of B7-H3 and B7-H4 in head and neck cancer
The prognostic impact of B7-H3 and B7-H4 in head and neck cancer Open
Introduction Immunotherapy through immune checkpoint inhibition is an option in many cancer entities. In HNSCC the inhibition of the PD1/PD-L1 (B7-H1) axis is approved as first line treatment for r/m HNSCC and is further being explored in …
View article: The prognostic impact of Axl and Gas6 in head and neck cancer
The prognostic impact of Axl and Gas6 in head and neck cancer Open
Introduction The receptor tyrosine kinase Axl is described as a driver for migration and metastasis as well as for resistance against molecular targeting agents and radio- and chemotherapy (RCT) in various tumor entities including head and…
View article: Tissue Microarray Analyses Suggest Axl as a Predictive Biomarker in HPV-Negative Head and Neck Cancer
Tissue Microarray Analyses Suggest Axl as a Predictive Biomarker in HPV-Negative Head and Neck Cancer Open
The receptor tyrosine kinase Axl is described to promote migration, metastasis and resistance against molecular targeting, radiotherapy, and chemotherapy in various tumor entities, including head and neck squamous cell carcinoma (HNSCC). S…
View article: Erratum
Erratum Open
International Journal of CancerVolume 150, Issue 10 p. E6-E6 ERRATUMFree Access Erratum This article corrects the following: Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivate…
View article: Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells
Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells Open
In head and neck squamous cell carcinoma (HNSCC), tumors positive for human papillomavirus (HPV) represent a distinct biological entity with favorable prognosis. An enhanced radiation sensitivity of these tumors is evident in the clinic an…
View article: Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src family kinases as prognostic markers and potential targets
Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src family kinases as prognostic markers and potential targets Open
Signal transduction via protein kinases is of central importance in cancer biology and treatment. However, the clinical success of kinase inhibitors is often hampered by a lack of robust predictive biomarkers, which is also caused by the d…
View article: Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer
Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer Open
Squamous cell carcinoma of the head and neck (HNSCC) consist of two distinct biological entities. While the numbers of classical, tobacco-induced HNSCC are declining, tumors caused by human papillomavirus (HPV) infection are increasing in …