Agnes Ssali
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View article: A mix of views: Perspectives on pregnant women's participation in maternal vaccine trials
A mix of views: Perspectives on pregnant women's participation in maternal vaccine trials Open
Building trust, providing accurate information, and engaging in transparent communication about the safety and intentions of maternal vaccines are crucial steps in fostering understanding and increasing participation in vaccine trials. Eff…
View article: Pregnant and breastfeeding women concerns during a group B Streptococcus phase ll clinical trial: A qualitative study in Kampala, Uganda
Pregnant and breastfeeding women concerns during a group B Streptococcus phase ll clinical trial: A qualitative study in Kampala, Uganda Open
Despite evidence that maternal vaccines can contribute to reduction of neonatal infections, vaccine hesitancy is a challenge in many low- and middle-income countries like Uganda. We conducted in-depth interviews with pregnant women and foc…
View article: Epidemiology of Group B <i>Streptococcus</i>: Maternal Colonization and Infant Disease in Kampala, Uganda
Epidemiology of Group B <i>Streptococcus</i>: Maternal Colonization and Infant Disease in Kampala, Uganda Open
Background Child survival rates have improved globally, but neonatal mortality due to infections, such as group B Streptococcus (GBS), remains a significant concern. The global burden of GBS-related morbidity and mortality is substantial. …
View article: Increasing Maternal Vaccination Awareness, by Working With Women Influencers in Kawempe Division, Uganda: A Brief Report
Increasing Maternal Vaccination Awareness, by Working With Women Influencers in Kawempe Division, Uganda: A Brief Report Open
Although the World Health Organization recommends 2 tetanus vaccine-containing injections in pregnancy, in Uganda, only 59.2% of pregnant women received a 2nd dose in 2022. We set out to (1) create awareness of maternal vaccine-preventable…
View article: Pharmacovigilance for Vaccines Used in Pregnancy: A Gap Analysis From Uganda
Pharmacovigilance for Vaccines Used in Pregnancy: A Gap Analysis From Uganda Open
Background: Despite the effectiveness of maternal vaccines, low- and middle-income countries grapple with inadequate safety monitoring systems. Robust safety surveillance is crucial to increasing vaccine confidence and timely identifying a…
View article: Youth and Mentor Experiences of a Disability Inclusive Youth Research Training and Mentorship Programme in Uganda
Youth and Mentor Experiences of a Disability Inclusive Youth Research Training and Mentorship Programme in Uganda Open
Young persons with disability are often excluded from research, especially in low-income countries. In this study, we evaluated a one-year Disability Inclusive Youth (DIY) training and mentoring programme to build research capacity among U…
View article: Etiology and Antimicrobial Resistance of Culture-Positive Infections in Ugandan Infants: A Cohort Study of 7000 Neonates and Infants
Etiology and Antimicrobial Resistance of Culture-Positive Infections in Ugandan Infants: A Cohort Study of 7000 Neonates and Infants Open
Background Epidemiological evidence about the etiology and antimicrobial resistance of neonatal infections remains limited in low-resource settings. We aimed to describe the etiology of neonatal infections in a prospective observational co…
View article: Rapid Point-of-care Testing to Inform Intrapartum Treatment of Group B <i>Streptococcus</i>–Colonized Women in Uganda
Rapid Point-of-care Testing to Inform Intrapartum Treatment of Group B <i>Streptococcus</i>–Colonized Women in Uganda Open
Introduction Maternal Group B Streptococcus (GBS) rectovaginal colonization is an important risk factor for invasive disease in neonates, yet availability of culture-based methods for detection is limited in low-resource settings. We evalu…
View article: Antenatal Screening for Hepatitis B Virus in Uganda: Missed Opportunities for Diagnosis and Treatment
Antenatal Screening for Hepatitis B Virus in Uganda: Missed Opportunities for Diagnosis and Treatment Open
Background Hepatitis B virus (HBV) infection is a significant cause of morbidity and mortality globally. The World Health Organization estimates that just 10.5% of individuals living with HBV globally are aware of their status. Antenatal c…
View article: Seroprevalence of Cytomegalovirus Among Pregnant Women at Kawempe National Referral Hospital, Uganda: A Cross-sectional Study
Seroprevalence of Cytomegalovirus Among Pregnant Women at Kawempe National Referral Hospital, Uganda: A Cross-sectional Study Open
Background Maternal primary cytomegalovirus (CMV) infection is associated with abortion and congenital anomalies. In Uganda, the burden of maternal CMV infection is not well studied. This study thus assessed the seroprevalence and factors …
View article: HIV Exposure and Neonatal Sepsis: A Descriptive Etiological Study
HIV Exposure and Neonatal Sepsis: A Descriptive Etiological Study Open
Background Low- and middle-income countries lack data on culture-confirmed sepsis in HIV-exposed infants, despite the reported heightened risk of infectious morbidity. This study describes culture-confirmed sepsis and antibiotic resistance…
View article: Early Childhood Neurodevelopmental Outcomes After Early Infant Invasive Group B Streptococcal Infection in Uganda
Early Childhood Neurodevelopmental Outcomes After Early Infant Invasive Group B Streptococcal Infection in Uganda Open
Background Group B streptococcal (GBS) sepsis during infancy is a leading cause of child mortality and an important contributor to long-term neurodisability. Data on outcomes among invasive GBS infection survivors in low- and middle-income…
View article: Infectious Causes of Stillbirths: A Descriptive Etiological Study in Uganda
Infectious Causes of Stillbirths: A Descriptive Etiological Study in Uganda Open
Background Every year an estimated 2–3 million babies are stillborn, with a high burden in Africa. Infection is an important driver of stillbirth. There is a lack of data on the bacterial causes of stillbirth in Uganda, contributing to a l…
View article: Community Perceptions of Neonatal Infection in Uganda
Community Perceptions of Neonatal Infection in Uganda Open
Background We investigated awareness of neonatal infections among a population of pregnant women and other community members in Kampala, Uganda. We explored perceived causes of neonatal infections and perceptions of appropriate treatments.…
View article: Caregivers and Healthcare Workers Experiences and Preferences with Use of Penicillin Prophylaxis in Young Children with Sickle Cell Anemia in Uganda
Caregivers and Healthcare Workers Experiences and Preferences with Use of Penicillin Prophylaxis in Young Children with Sickle Cell Anemia in Uganda Open
Introduction: Bacterial infections are a major cause of sickle cell anemia related morbidity and mortality in young children with sickle cell anemia (SCA) in Sub-Saharan Africa. Penicillin prophylaxis is therefore recommended as a standard…
View article: Structural and social factors affecting COVID-19 vaccine uptake among healthcare workers and older people in Uganda: A qualitative analysis
Structural and social factors affecting COVID-19 vaccine uptake among healthcare workers and older people in Uganda: A qualitative analysis Open
The COVID-19 vaccine rollout programme in Uganda was launched in March 2021 for priority groups: Healthcare Workers (HCWs), older persons (≥50 years), and persons with chronic conditions. Misinformation, distrust in healthcare systems, and…
View article: Perceptions, attitudes, and willingness of healthcare and frontline workers to participate in an Ebola vaccine trial in Uganda
Perceptions, attitudes, and willingness of healthcare and frontline workers to participate in an Ebola vaccine trial in Uganda Open
Overall, information sharing leads to a better understanding and acceptance of vaccine trials and a positive vaccination experience can be a deciding factor in the acceptance of others. Particular attention should be paid to involving the …
View article: Contextual, structural, and mental health experiences of children of women engaged in high-risk sexual behaviour in Kampala: a mixed method study
Contextual, structural, and mental health experiences of children of women engaged in high-risk sexual behaviour in Kampala: a mixed method study Open
Children born to women who sell sex for money or commodities may face economic and social insecurity because of their mother’s work, particularly in settings where sex work is illegal. From October 2020 to May 2021, we conducted a study wi…
View article: Structural, Social, and Contextual factors influencing COVID-19 vaccine uptake: A qualitative methods study among Healthcare Workers and Older People in Uganda
Structural, Social, and Contextual factors influencing COVID-19 vaccine uptake: A qualitative methods study among Healthcare Workers and Older People in Uganda Open
Background The COVID-19 vaccine rollout program in Uganda was launched in March 2021 with Healthcare Workers (HCWs), older persons (≥50 years), and persons with chronic conditions as priority groups for vaccination. To inform the vaccine r…
View article: COVID-19 disease and vaccination in pregnancy: understanding knowledge, perceptions and experiences among pregnant women and community leaders in Uganda
COVID-19 disease and vaccination in pregnancy: understanding knowledge, perceptions and experiences among pregnant women and community leaders in Uganda Open
Background We investigated pregnant women and community leaders’ knowledge, perceptions and experiences of the coronavirus disease 2019 (COVID-19) vaccination program during pregnancy in Uganda and how this changed over the course of the p…
View article: Understanding perceptions of schistosomiasis and its control among highly endemic lakeshore communities in Mayuge, Uganda
Understanding perceptions of schistosomiasis and its control among highly endemic lakeshore communities in Mayuge, Uganda Open
Background Schistosomiasis is a neglected tropical disease and a serious global-health problem with over 230 million people requiring treatment, of which the majority live in Africa. In Uganda, over 4 million people are infected. Extensive…
View article: Establishing a single-sex controlled human <i>Schistosoma mansoni</i> infection model for Uganda: protocol for safety and dose-finding trial
Establishing a single-sex controlled human <i>Schistosoma mansoni</i> infection model for Uganda: protocol for safety and dose-finding trial Open
Control of schistosomiasis depends on a single drug, praziquantel, with variable cure rates, high reinfection rates, and risk of drug resistance. A vaccine could transform schistosomiasis control. Preclinical data show that vaccine develop…
View article: The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: Findings from a qualitative methods study of participants and researchers in Botswana and Uganda
The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: Findings from a qualitative methods study of participants and researchers in Botswana and Uganda Open
Background The AMBITION-cm trial for HIV-associated cryptococcal meningitis demonstrated that a single, high-dose of liposomal amphotericin (AmBisome) plus 14-days of oral flucytosine and fluconazole was non-inferior in terms of all-cause …
View article: Use of Services among Female Sex Workers Receiving a Comprehensive HIV Enhanced Prevention Intervention in Kampala, Uganda: A Cross-sectional Study
Use of Services among Female Sex Workers Receiving a Comprehensive HIV Enhanced Prevention Intervention in Kampala, Uganda: A Cross-sectional Study Open
We estimated the prevalence and factors associated with the use of a dedicated HIV prevention, care, and treatment service for female sex workers (FSWs) in Kampala, Uganda. Between October 2017 to January 2018, we conducted a cross-section…